Expert in Analytical Optical Spectroscopy, Chemometrics, Petroleum, Polymorphs and Diagnostics
The expert and his research group have focused on applications of all areas of optical spectroscopy to a broad range of environmental, medical, pharmaceutical and bio-terrorism problems. Environmental problems have included water and air pollution, oil spills and corrosion. Medical applications have been concerned with in vivo and in vitro monitoring of glucose, cholesterol, blood oxygen and plaque in addition to studying spectral images of skin, bone and brain tissue. Pharmaceutical research has been directed towards polymorphic crystals, mixing, dissolution, and tablet specifications. Spectra of several thousand bacteria of many genius/species have been measured and processed in developing rapid methods for identifying pathogenic bacteria that might be encountered in bio-terrorism.
Much of the expert’s research has been in the use of vibrational spectra to solve real world problems. The focus has been on both the mid- and near-infrared regions, since certain problems are more adaptable to one region than the other. Polymorphic crystals, liquid crystals, oil spills, corrosion, blood chemicals, and air pollutants have been investigated in the mid-infrared region and with Raman spectra. Near-infrared spectra have been used to study cervical cancer cells, gases, natural gas, and aqueous solutions of salts, temperature dependence of water, fabric dyes and active pharmaceutical ingredients. Fourier transform spectrometers are used both for mid- and near-infrared measurements.
Expert and his students built one of the first miniature spectrometers for the near-infrared region and used the instrument for on-line monitoring of the composition and BTU content of natural gas. This research entailed measuring spectra of pure components of natural gas both on a high-resolution instrument and developing a calibration method for modeling the predictive performance of a low-resolution, miniature spectrometer. In conjunction with this research project, the first near-infrared gas-phase library was developed.
Two practical problems were the objects of investigations in the ultraviolet-visible (UV-VIS) spectral region. The first involved developing the computer technology for monitoring dissolution of active ingredients in pharmaceutical tablets. Initially, a sipper type system was used to extract samples into cuvettes from a Hanson dissolution (six-bath) system under computer control; the software was developed to control the system and to predict the concentrations of the active ingredients. Later, the sipper system was replaced with a multiplexing, six fiber optic system, which made it possible to monitor the concentrations in real times. The other major investigation in the ultraviolet region was to develop the computer methodology for identifying chemicals and specifically biochemicals from their UV spectra, since UV detect is of utmost importance for HPLC detection.
In the area of computerization and chemometrics, the expert was on the ground flood of interfacing analytical instruments to computers during the 1970s. The work on interfacing instruments led to some of the first digitized spectral data for chemical analysis. The interfacing efforts were closely followed by simultaneous work on algorithms for process the spectra data using statistical analysis or what is now known as chemometrics. Algorithms included developing methodologies for clustering and matching spectra for qualitative analysis; and K-matrix, P-matrix, multivariate, Principal Component Regression (PCR) and Partial Least Squares (PLS) for quantitative analysis. Methodologies also included calibration transfers, Fourier Transform and derivative processing for both qualitative and quantitative analysis.
Consulted for Beckman Instruments (now Beckman-Coulter, Fullerton, CA) instrument division from 1977 until 1984 on developing software algorithms for processing spectroscopic data for qualitative and quantitative analysis. He was also involved with the development of a Fourier Transform Infrared SpectrometerConsulted for Beckman Instruments (now Beckman-Coulter, Fullerton, CA) biomedical division from 1987 until 1992 on developing and testing software for quantitative analysis in biological systems.Consulted for Digilab (now Varian Instruments, Cambridge, MA) from 1985 to 1991 on developing and implementing quantitative analysis software.Consulted for Berringer-Manheim (Manheim, Germany) from 1991 to 1994 on spectroscopic methods for measuring blood glucose.Consulted for SensIR Technologies (now Smith's Detection, Danbury, CT) from 2002 to 2008 on spectroscopic methods for identifying bacteria and chemical mixtures.
Expert may consult nationally and internationally, and is also local to the following cities: Boston, Massachusetts - Worcester, Massachusetts - Springfield, Massachusetts - Lowell, Massachusetts - Cambridge, Massachusetts - Bridgeport, Connecticut - New Haven, Connecticut - Hartford, Connecticut - Waterbury, Connecticut - Providence, Rhode Island
|Year: 1967||Degree: Ph.D.||Subject: Physical Chemistry||Institution: University of Minnesota - Minneapolis|
|Year: 1962||Degree: M.S.||Subject: Chemistry||Institution: Xavier University - Cincinnati|
|Year: 1960||Degree: B.S.||Subject: Chemistry||Institution: Xavier University - Cincinnati|
|Years: 1968 to Present||Employer: Undisclosed||Title: Undisclosed||Department: Chemistry||Responsibilities: Taught graduate and undergraduate courses in physical chemistry from 1968 to 1980, and in analytical chemistry from 1980 until the present.|
|Years: 1966 to 1968||Employer: University of Maryland||Title: NIH Post-doctoral Fellow||Department: Chemistry||Responsibilities: Performed research crystals and liquids using mid-infrared and Raman spectroscopy|
|Years: 2002 to 2002||Agency: National Institutes of Health||Role: Review Panel||Description: Reviewed NIH proposals and sat on committee|
|Years: 1995 to 1995||Agency: National Institutes of Health||Role: Review Panel||Description: Sat on committee to review and evaluate large institution proposal from the University of Georgia|
|Years: 1988 to 1988||Agency: National Institutes of Health||Role: Chaired Review Committee||Description: Committee to evaluate institutional proposal from Battelle Memorial Institute, Columbus, O.|
|Associations / Societies|
|American Chemical Society
Coblentz Society (Member of Board of Managers,1978 to 1982)
Society for Applied Spectroscopy
American Society for Testing and Materials (Associate Member 1987- present)
| General Chair of the 1997 Annual Meeting of the Federation of Analytical Chemistry and Spectroscopy Societies
Editorial Board Member, Applied Spectroscopy (1996-1998)
Editorial Board, J. Instrumentation Science and Technology (1994-present)
Editorial Board, Spectroscopy (1996-present)
Editorial Board, Vibrational Spectroscopy (2001-2006)
|Awards / Recognition|
| -Research Medal of the Worshipful Company of Dyers for 1997, London, April 29, 1998.
-1996 Eastern Analytical Symposium Award in Process Control for the Development of a NIR High Pressure Gas Cell, presented by Perstorp Analytical/NIRSystems.
-1994 Expert F. Meggers Award from the Society for Applied Spectroscopy for Development of a Universal Approach to Determine the Physical and Chemical Properties of Water.
-Cover Feature: Journal of Applied Spectroscopy, May, 1993.
-National Graduate Spectroscopy Award: Presented by the Chicago Section of the Society for Applied Spectroscopy, l966
-DuPont Summer Fellowship for Graduate Studies, l963 to l966;
|Medical / Professional|
|National Institutes of Health Post-Doctoral Fellow at the University of Maryland, 1966 to 1968.|
|Publications and Patents Summary|
|He has 166 publications, 5 patents, one book and 9 book chapters on applied spectroscopy|
|Expert Witness Experience|
|Served as expert witness in pulse oximeter patent infringement case in 2008 (settled out of court).
Served as expert witness in liquid drug patent infringement case in 2003-04 (deposed, but settled out of court).
Served as expert on Raman spectra of pharmaceutical methodology patent infringement case 2005-06 (did not go to court).
Served as expert witness on pharmaceutical polymorph patent infringement case 2000-2001 (did not go to court).
Served as expert witness on pharmaceutical polymorph patent infringement cases 1994-1997 (deposed 5 times, testified in court once).
Served as expert witness in oil spill cases 1975-1978 (deposed twice)
|Training / Seminars|
|Presented training courses on multivariate analysis using K-matrix, P-matrix, Principal Component Regression (PCR) and Partial Least Squares (PLS).|
|Served as a consultant for four spectroscopic instrument companies for multiple years at each company.
Served as a consultant for three medical diagnostic companies for multiple years at each company.
|Other Relevant Experience|
|Expert in algorithm developments and interfacing spectroscopic instrumentation.|