Expert Details

Expert in Automated Chemical Sensors

Expert ID: 107891 Massachusetts, USA

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LABORATORY COMPUTERIZED ANALYTICAL INSTRUMENTATION DESIGN; CHEMICAL AUTOANALYSIS. Expert has spent much of his career developing systems or subsystems for devices accomplishing automated chemical analysis. He has experience in all phases of this process, from basic research into sensors to the transition to manufacturing under GMP control.

ELECTROANALYTICAL CHEMISTRY; ELECTROCHEMICAL ANALYSIS; ELECTROCHEMICAL SENSOR. Most of the automated chemical analyzers Expert developed have used electroanalytical principles. He has experience in potentiometric, polarographic, and voltammetric analysis, and their applications to both research and the finished products. He also has some knowledge regarding CHEMFETs.

POLAROGRAPHY; VOLTAMMETRY. Expert's expertise includes the application of both polarographic and voltammetric sensors for clinical analysis. He is proficient in oxygen sensors their unique applications to electrochemical immunoassay.

ION-SELECTIVE ELECTRODES; POTENTIOMETRIC ANALYSIS. Expert has developed several sensors for clinical analysis using ion-selective electrodes, including sensors for sodium, potassium, and chloride ions. In each case, his work has included both the development and design of the sensor, along with the creation of manufacturing and test procedures.

BIOMEDICAL CHEMICAL SENSOR; OXYGEN ANALYZER; ELECTROCHEMICAL OXYGEN SENSOR. Expert completed his master's thesis and doctoral dissertation on theoretical and experimental aspects of oxygen sensors. More recently, he developed a prototype of a fluorimetric oxygen sensor, and has continued to be involved in the field as a consultant.

GLUCOSE SENSOR; BLOOD GLUCOSE MEASUREMENT. Expert has developed many versions of an electrochemical glucose sensor for clinical applications. His experience also includes the development of photometric assays for glucose, as well as a due diligence investigation on the prospects for a non-invasive glucose sensor.

BLOOD GAS MONITORING EQUIPMENT. Over the course of his career, Expert has constructed sensors for all of the analytes in a blood gas system. He has developed several novel prototype schemes for calibration and quality control of blood gas equipment.

CHEMICAL ENGINEERING. Expert's three degrees are all in chemical engineering. This discipline has been applied to transport phenomena analysis of all the beforementioned sensors, and has been used in recent work in microfiltration, analytical systems development, and chromatographic and flow-injection analyses.


Contributed to the development and testing of a blood filtration system.Performed market and technical analyses of the point-of-care clinical testing environment.Conducted an analysis of the feasibility of electrochemical process control for pulp bleaching.Current projects include: reagent manufacturing and QA consulting for a small diagnostics company; development of non-invasive sensors for glucose and other metabolites; and development of a CLIA waiver application for a diagnostics firm.

Expert may consult nationally and internationally, and is also local to the following cities: Boston, Massachusetts - Worcester, Massachusetts - Springfield, Massachusetts - Lowell, Massachusetts - Cambridge, Massachusetts - Brockton, Massachusetts - New Bedford, Massachusetts - Hartford, Connecticut - Manchester, New Hampshire - Providence, Rhode Island

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Education

Year Degree Subject Institution
Year: 1977 Degree: PhD Subject: Chemical Engineering Institution: Northwestern University
Year: 1972 Degree: MS Subject: Chemical Engineering Institution: Northwestern University
Year: 1969 Degree: BChE Subject: Chemical Engineering Institution: Cooper Union

Work History

Years Employer Title Department Responsibilities
Years: 1991 to Present Employer: Undisclosed Title: Indpendent Consultant Department: Responsibilities: Providing technical solutions to analytical issues for firms in analytical and biomedical sectors.
• Research on novel nanomaterial under DOD SBIR contracts:
• Direction of sensor R&D for startup in treatment of atrial fibrillation (AF).
• Part-time director of chemistry and reagent manufacturing for small IVD firm.
• Technology development for non-invasive optical assays in vivo; wrote funded proposals for
Phase I and Phase II SBIR grants from NIH; six issued patents.
• Reviewer for NIH SBIR proposals within study sections since 2000.
• Technology assessment for novel process analytical sensor.
• Optimized reactor subsystem for macromolecule synthesis device.
• Examined alternatives for ultratrace wastewater metal analysis.
• Researched technologies for blood and component processing system.
• Developed filtration system for biological materials.
• Completed temperature control and deaeration system for medical fluid process.
• Recommended reagent production and packaging processes.
• Created development proposals for NSF, DOD, and ARPA for chemical sensors.
• Evaluated long-term prospective manufacturing costs/yields for POC sensor systems.
Years: 1988 to 1991 Employer: MEDICA CORPORATION Title: Vice-President Department: Science and Technology Responsibilities: On board of directors of a small, venture-capital funded company producing diagnostic devices
for alternate site markets. Responsible for all R&D activities and overall corporate strategy.
Managed chemistry, electronics, software, and engineering development. Sales now running over
$5 million per year.
• Completed re-engineering of hardware and software and reintroduction to manufacturing of
first corporate product, an ion-selective electrode analyzer.
• Initiated and completed introduction of second product, an additional analyte added to
analyzer menu.
• Negotiated OEM arrangements with physicians' office distributors.
• Continued research on two new products (two patents applied for).
• Also responsible for quality assurance and regulatory affairs (FDA) functions.
Years: 1984 to 1988 Employer: ALYX MEDICAL Title: Director Department: Electrochemistry and Systems Integration Responsibilities: Responsible for all electrochemical R&D and for system-level integration of a physician's office
chemistry analyzer. Managed chemistry and engineering staff.
• Evaluated reagent systems for analyzer and selected analytes for initial launch.
• Developed and parametrized large portions of analyzer software.
• Designed and evaluated analyzer fluidics and sample handling.
• Researched, built, and evaluated prototype immunoelectrochemical detector.
• Created ion-selective electrode system for physician's office instrument.
Years: 1983 to 1984 Employer: CORNING MEDICAL Title: Senior Research Scientist Department: Responsibilities: Responsible for segments of electrochemistry R&D for clinical instrumentation. Managed 3
senior technologists.
• Researched, assembled, and evaluated prototype enzyme electrodes for glucose, urea,
and creatinine.
• Led development of enzyme immobilization systems for enzyme electrodes.
• Modeled, built, and tested improved sensor and calibration methods for blood gas/electrolyte
systems.
• Evaluated competitive measurement systems and recommended research plans.
• Developed five-year plan for staff and programs in analytical chemistry R&D.
• Generated seven invention disclosures (one patent applied for).
Years: 1978 to 1981 Employer: BIORESEARCH, INC Title: Senior Chemical Engineer Department: Responsibilities: Conducted R&D in electrochemical devices in biomedical and chemical process applications.
• Built and evaluated in vivo a non-invasive wound healing sensor.
• Researched, developed, and evaluated a chronic respiratory support system.
• Modeled a non-invasive blood flow sensor.
• Analyzed data from an electrochemical ore flotation process monitor under NSF contract.
• Designed and assembled an oil-in-water pollution monitor based on immobilized bacterial
electrodes under a Naval research contract.
• Analyzed data from a fast coliform bacterial detection system.

Career Accomplishments

Associations / Societies
Expert is a member of the American Institute of Chemical Engineers (AIChE), the American Chemical Society (ACS), and the American Association of Clinical Chemistry (AACC).
Awards / Recognition
He was the recipient of an NIH Traineeship in Biomedical Engineering and a New York State Regents Scholarship.
Publications and Patents Summary
Expert has three publications and seven patents to his name.

Fields of Expertise

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