Expert in Biochemistry; Infectious Disease Diagnostics Technology and Running of COVID-19 Clinical Diagnostics Lab
Expert ID: 736476 California, USA
From March to November 2020, Expert developed and lead the Biohub/UCSF COVID19 clinical testing facility known as CLIAHUB, processing over 1,000 SARS-CoV2 PCR tests per day for Public Health Departments across California.
Available for panels, in depth interviews, and surveys only.
Expert may consult nationally and internationally, and is also local to the following cities: San Francisco, CA - Los Angeles, CA - San Diego, CA
|Year: 2012||Degree: PhD||Subject: Chemistry and Chemical Biology||Institution: University of California San Francisco|
|Year: 2003||Degree: AB||Subject: Molecular, Cellular and Developmental Biology||Institution: Bryn Mawr College|
|Years: 2019 to Present||Employer: Undisclosed||Title: Assistant Adjunct Professor||Department: Dept. of Microbiology and Immunology||Responsibilities: Member, UCSF COVID-19 Research Coordination Task Force|
|Years: 2016 to 2020||Employer: Chan Zuckerberg Biohub||Title: Group Leader||Department: Infectious Disease Initiative||Responsibilities: Lead the effort to launch the CLIAhub COVID19 testing lab, a collaboration between CZ Biohub and UCSF.
• Lead the development and validation of our RT-PCR LDT (under review for FDA EUA authorization) which occurred over the course of 8 days, launching March 20th 2020
• Grew the lab to 8 RNA extraction stations, 2 shifts, and over 1,000 samples/day processed with a workforce of over 100 volunteer scientists
• Transitioned from leading a volunteer workforce to managing a staff of 12 Laboratory Specialists
• Built and maintained relationships with over 20 California county Public Health departments for which CLIAhub provided free testing
• Provided RT-PCR COVID19 testing for numerous community clinical research studies at UCSF
February 2017 – February 2020
Built and lead a collaborative team of 4 to bring CRISPR-based infectious disease diagnostics to the Biohub.
• Developed and optimized the FLASH (Finding Low Abundance Sequences by Hybridization) method for targeted-enrichment NGS as well as more rapid, sequencing-free methods.
• Lead Biohub efforts to use sequencing to detect and analyze outbreaks of hospital-acquired infections in collaboration with UCSF’s Infection Control team.
|Years: 2016 to 2017||Employer: Joe DeRisi’s Lab, University of California San Francisco (UCSF)||Title: Chan Zuckerberg Biohub Postdoctoral Scholar||Department:||Responsibilities:|
|Years: 2014 to 2016||Employer: Joe DeRisi’s Lab, University of California San Francisco (UCSF)||Title: Postdoctoral Scholar/HHMI Research Associate||Department:||Responsibilities: Produced recombinant CRISPR/Cas9 ribonucleoprotein complex and developed Cas9-based tools for depleting abundant sequences and enriching rare sequences in NGS libraries. Developed a method for plasmid-free genome editing in the malaria parasite P. falciparum. Trained and managed 3 technicians, mentored numerous students and two TechWomen interns, supervised journal club, assisted with Genomics Bootcamps run by the UCSF Development Office.|
|Years: 2012 to 2013||Employer: German Center for Neurodegenerative Diseases (DZNE)||Title: Postdoc||Department:||Responsibilities: C. elegans proteomics.|
|Awards / Recognition|
|Dean’s Recognition for Excellence in Teaching Award from UCSF’s School of Pharmacy|
|Publications and Patents Summary|
|[Selected] Oral Presentations:
• Next Generation Dx Virtual Summit
• Association for Molecular Pathology meeting
• American Society for Microbiology’s ASM Microbe meeting, Mini-Conference on Microbial Genomics and Public Health
• Wellcome Genome Campus Retreat on CRISPR Approaches for Apicomplexans
• Cold Spring Harbor Laboratory meeting on Genome Engineering: The CRISPR/Cas Revolution
• Keystone meeting on Precision Genome Engineering and Synthetic Biology
• 7th General Meeting of the International Proteolysis Society
[Selected] Publications: 22
Patents Filed: 2
|Training / Seminars|
|Adobe Illustrator Workshop TA, UCSF Office of Career and Professional Development, 2011-16.
Graduate of UCSF’s “Idea to IPO” course on the business of biotechnology, 2008.
|Contract editor in biochemistry and related fields for American Journal Experts.|
|Other Relevant Experience|
|Professional Mentor to Emerging Leaders from developing countries for the U.S. Department of State’s TechWomen program, 2015-present. Each year this consists of a month of intensive mentoring and training in basic lab techniques, including CRISPR, cloning, NGS. Also served on Selection Committees.