Expert in Biochemistry; Infectious Disease Diagnostics Technology and Running of COVID-19 Clinical Diagnostics Lab
Expert ID: 736476 California, USA
From March to November 2020, Expert developed and lead the Biohub/UCSF COVID19 clinical testing facility known as CLIAHUB, processing over 1,000 SARS-CoV2 PCR tests per day for Public Health Departments across California.
|Year: 2012||Degree: PhD||Subject: Chemistry and Chemical Biology||Institution: University of California San Francisco|
|Year: 2003||Degree: AB||Subject: Molecular, Cellular and Developmental Biology||Institution: Bryn Mawr College|
|Years: 2019 to Present||Employer: Undisclosed||Title: Assistant Adjunct Professor||Department: Dept. of Microbiology and Immunology|
Responsibilities:Member, UCSF COVID-19 Research Coordination Task Force
|Years: 2016 to 2020||Employer: Chan Zuckerberg Biohub||Title: Group Leader||Department: Infectious Disease Initiative|
Responsibilities:Lead the effort to launch the CLIAhub COVID19 testing lab, a collaboration between CZ Biohub and UCSF.
• Lead the development and validation of our RT-PCR LDT (under review for FDA EUA authorization) which occurred over the course of 8 days, launching March 20th 2020
• Grew the lab to 8 RNA extraction stations, 2 shifts, and over 1,000 samples/day processed with a workforce of over 100 volunteer scientists
• Transitioned from leading a volunteer workforce to managing a staff of 12 Laboratory Specialists
• Built and maintained relationships with over 20 California county Public Health departments for which CLIAhub provided free testing
• Provided RT-PCR COVID19 testing for numerous community clinical research studies at UCSF
February 2017 – February 2020
Built and lead a collaborative team of 4 to bring CRISPR-based infectious disease diagnostics to the Biohub.
• Developed and optimized the FLASH (Finding Low Abundance Sequences by Hybridization) method for targeted-enrichment NGS as well as more rapid, sequencing-free methods.
• Lead Biohub efforts to use sequencing to detect and analyze outbreaks of hospital-acquired infections in collaboration with UCSF’s Infection Control team.
|Years: 2016 to 2017||Employer: Joe DeRisi’s Lab, University of California San Francisco (UCSF)||Title: Chan Zuckerberg Biohub Postdoctoral Scholar||Department:|
|Years: 2014 to 2016||Employer: Joe DeRisi’s Lab, University of California San Francisco (UCSF)||Title: Postdoctoral Scholar/HHMI Research Associate||Department:|
Responsibilities:Produced recombinant CRISPR/Cas9 ribonucleoprotein complex and developed Cas9-based tools for depleting abundant sequences and enriching rare sequences in NGS libraries. Developed a method for plasmid-free genome editing in the malaria parasite P. falciparum. Trained and managed 3 technicians, mentored numerous students and two TechWomen interns, supervised journal club, assisted with Genomics Bootcamps run by the UCSF Development Office.
|Years: 2012 to 2013||Employer: German Center for Neurodegenerative Diseases (DZNE)||Title: Postdoc||Department:|
Responsibilities:C. elegans proteomics.
|Awards / Recognition|
|Dean’s Recognition for Excellence in Teaching Award from UCSF’s School of Pharmacy|
|Publications and Patents Summary|
|[Selected] Oral Presentations:
• Next Generation Dx Virtual Summit
• Association for Molecular Pathology meeting
• American Society for Microbiology’s ASM Microbe meeting, Mini-Conference on Microbial Genomics and Public Health
• Wellcome Genome Campus Retreat on CRISPR Approaches for Apicomplexans
• Cold Spring Harbor Laboratory meeting on Genome Engineering: The CRISPR/Cas Revolution
• Keystone meeting on Precision Genome Engineering and Synthetic Biology
• 7th General Meeting of the International Proteolysis Society
[Selected] Publications: 22
Patents Filed: 2
|Training / Seminars|
|Adobe Illustrator Workshop TA, UCSF Office of Career and Professional Development, 2011-16.
Graduate of UCSF’s “Idea to IPO” course on the business of biotechnology, 2008.
|Contract editor in biochemistry and related fields for American Journal Experts.|
|Other Relevant Experience|
|Professional Mentor to Emerging Leaders from developing countries for the U.S. Department of State’s TechWomen program, 2015-present. Each year this consists of a month of intensive mentoring and training in basic lab techniques, including CRISPR, cloning, NGS. Also served on Selection Committees.