Expert Details

Expert in Biomaterials, Medical Device Rapid Prototyping, and Laser Processing of Materials

Expert ID: 724829 North Carolina, USA

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Since their invention in the early 1960s, lasers have found many uses in the medical field. Most current medical applications of lasers involve use as a “universal scalpel” in minimally invasive surgeries, which offer little contact, little blood loss, shorter operating times, and less postoperative pain than conventional techniques. Laser in situ keratomileusis (LASIK) refractive corneal surgery, coagulation for retinal detachment, and skin treatments are only some of the current applications for lasers in medicine. In the future, lasers will also serve to create novel medical devices with unique biological functionalities. Microstructured and nanostructured biomaterials have recently been fabricated via pulsed laser deposition, laser direct writing, and two photon-polymerization processes.

Expert is the recipient of the 2005 Office of Naval Research Young Investigator Award. His work, which was done in coordination with the Naval Research Laboratory, has shown that laser direct writing can fabricate differentially adherent surfaces for cell attachment, three-dimensional neuronal cell networks, and other structures with unique biological properties. Matrix-assisted pulsed laser evaporation-direct write (MAPLE-DW) is a novel laser direct writing technique for micrometer-scale resolution transfer of small amounts of polymers, biological materials, and eukaryotic cells. This technique may also be used for selective ablation of material. Expert’s work has shown that his technology has the potential to allow the development of tailored artificial tissues that match the geometries of injured, damaged, or missing tissues.

In addition, Expert has received funding from the National Institute of Biomedical Imaging and Bioengineering for the development of novel nanoporous membranes. Unlike many metal or polymer surfaces, diamond-like carbon-coated surfaces do not adsorb fibrous proteins or cellular material. The term “diamond-like carbon (DLC)” often refers to amorphous carbon thin films containing some sp3 hybridized atoms. These materials exhibit atomic number densities greater than 3.19 g/cm^3, and often possess densities closer to that of diamond (3.51 g/cm^3) than that of graphite (2.26 g/cm^3). Diamond-like carbon exhibits cell compatibility, corrosion resistance, lubricity, and wear resistance, and can serve as a “hermetic seal” for metal, ceramic, or polymer biomaterials.

Expert has also developed diamond-like carbon-silver-platinum nanocomposite films, in which silver and platinum form nanoparticle arrays within the diamond-like carbon matrix. Films containing both silver and platinum demonstrate enhanced antimicrobial activity during in vitro studies, due to formation of a galvanic couple that accelerates the release of silver ions. His most recent studies have shown that three-dimensional medical devices may be created using two photon induced polymerization. This work, which is being done in collaboration with researchers at Laser Zentrum Hannover, has shown that this rapid prototyping process may be used to create microstructured medical devices with a larger range of sizes and shapes than conventional microfabrication techniques. The two photon polymerization process involves both temporal and spatial overlap of photons in order to induce chemical reactions between starter molecules and monomers within a transparent medium. Near simultaneous absorption of two photons creates a so-called virtual state for sever


Expert may consult nationally and internationally, and is also local to the following cities: Raleigh, North Carolina - Greensboro, North Carolina - Durham, North Carolina - Winston Salem, North Carolina - Fayetteville, North Carolina - Cary, North Carolina - High Point, North Carolina - Greenville, North Carolina - Rocky Mount, North Carolina - Lynchburg, Virginia

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Education

Year Degree Subject Institution
Year: 2002 Degree: PhD Subject: Materials Science and Engineering Institution: North Carolina State University
Year: 2001 Degree: MD Subject: Medicine Institution: Wake Forest University
Year: 1996 Degree: BA Subject: Chemistry Institution: North Carolina State University

Work History

Years Employer Title Department Responsibilities
Years: 2005 to Present Employer: Undisclosed Title: Professor Department: Biomedical Engineering Responsibilities:
Years: 2003 to 2005 Employer: Georgia Institute of Technology Title: Assistant Professor Department: Responsibilities:

Career Accomplishments

Associations / Societies
AAAS, ASM International, American Ceramic Society, TMS
Awards / Recognition
2010: American Ceramic Society Global Star Award
2009: ASM International Fellow
2009: TMS Structural Materials Division JOM Best Paper Award
2008: NCSU Sigma Xi Faculty Research Award
2007: AAAS Fellow
2007: UNC Jefferson-Pilot Fellowship in Academic Medicine
2006-: Marquis Who's Who in Medicine and Healthcare
2006, 2008: Invited Participant National Academies Keck Futures Initiative
2006: National Science Foundation Faculty Early Career Development (CAREER) Award
2006: UNC Junior Faculty Development Award
2005: Office of Naval Research Young Investigator Award
2004: Georgia Tech Class of 1969 Teaching Fellow
2004: The Minerals, Metals & Materials Society (TMS) Young Leader
2002: Alpha Sigma Mu Metallurgy Honor Society
Publications and Patents Summary
He is an author of over one hundred publications as well as several book chapters on nanoscale and microscale processing, characterization, and modeling of biological and biomedical materials. He currently serves as an editorial board member for several academic journals, including as editor-in-chief of Materials Science and Engineering C: Materials for Biological Applications (Elsevier). Expert has also edited a number of books.

Additional Experience

Training / Seminars
Expert has provided tutorials on biomaterials to several external organizations, including The Minerals, Metals & Materials Society (TMS), the Oak Ridge Center for Advanced Studies, and Northwestern University.
Marketing Experience
Expert has made several distinguished contributions at the interface of materials engineering and medicine. In particular, his efforts have significantly increased collaboration and interaction among medical device manufacturers, biomaterials engineers, and clinicians. For example, he has brought together orthopaedic surgeons, metal alloy manufacturers, medical device manufacturers, and biomaterials engineers as committee head of Materials and Processes for Medical Devices, an ASM-International publication. This publication provides information on basic medical science; biomaterials processing, characterization, and modeling; fabrication of medical devices; and industry information. MPMD is distributed to a wide audience; over 10,000 copies are currently distributed to manufacturers, industrial researchers, academic scientists, educators, sales staff, and surgeons on a quarterly basis. In addition, he has organized or is organizing “Next Generation Biomaterials” symposia at the 2005-2008 Materials Science and Technology meetings, which are sponsored by the American Ceramic Society (ACerS), The Minerals, Metals & Materials Society (TMS), and ASM-International (formerly the American Society for Metals). The presentation topics at these symposia include bioceramics; biomimetic materials; biomaterial surfaces; metallic implant materials; nanoparticles for medical diagnosis and treatment; novel materials for drug delivery and biosensing; and scaffolds for tissue engineering.

Finally, Expert has also taken a leadership role in the development of interdisciplinary tutorials on the interaction between the human body environment and synthetic materials. He has provided tutorials on biomaterials to several organizations, including the Minerals, Metals & Materials Society, the Oak Ridge Center for Advanced Studies, and Northwestern University. He has developed innovative problem-based learning tutorials on several biomaterials topics, including nucleic acids, proteins, cell structure, tissue engineering, biotribology, biosensing, and drug delivery. These courses are consistently requested by individuals who are either seeking careers or developing additional skills in the rapidly growing medical device industry.

Fields of Expertise

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