Expert Details

Expert in Biomedical and Pharmacokinetic Modeling and Programming

Expert ID: 723721 Canada

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Expert has performed experimental work in biochemistry for his doctoral thesis. This work included isolation of mitochondria from Neurospora crassa and rat liver, isolation and purification of membrane proteins by electrophoresis and reverse-phase chromatography, gel electrophoresis and use of radioactive tracers to label membrane proteins. Expert has performed experimental
research in the uptake and metabolism of substrates using the perfused rat liver and the dog liver in vivo, using mainly the multiple indicator technique.

Expert performed experimental work pertaining to the uptake and metabolism of drugs and substrates in the whole organs (mainly perfused rat liver and dog live in vivo) using the multiple-indicator dilution technique. This included the preparation of radioactive tracers to be applied to the organ and analysis of blood samples by
ion-exchange chromatography, gamma spectroscopy and liquid scintillation spectroscopy. Expert has analyzed these results using mathematical models including mass transport and metabolic transformation. Expert has also analyzed pharmacokinetic data for several contract research organizations.

Expert has written and applied specialized software for the simulation of mass transport and metabolism. This software was used for the evaluation of experiments using mainly the multiple indicator technique, a method for
investigation uptake and transport of substances in whole organs by means of radioactive tracers. The software was written in FOTRAN (9000 lines). Expert participated actively in the development and maintenance of simulation
software "JSim", written in Java and FORTRAN. JSim is a Java-based simulation system for building quantitive numeric models and analyzing them with respect to experimental reference data. Expert has knowledge of most major programming languges.

Array

Programming of software for evaluation of enzyme kinetics for a research contract organizationEvaluation of pharmacokinetic data for two research contract organizations

Education

Year Degree Subject Institution
Year: 1971 Degree: Dr.rer.nat (PhD equivalent) Subject: Biochemistry Institution: Ludwig-Maximilian-Univ Munich
Year: 1968 Degree: Diplom (MSc equivalent) Subject: Chemistry Institution: Ludwig-Maximilian-Univ Munich

Work History

Years Employer Title Department Responsibilities
Years: 1985 to Present Employer: Undisclosed Title: Medical Scientist/Associate Professor Department: Research Institute Responsibilities: Experimental work in radioactive tracers, modeling and simulation of haptic tranport and metabolism. Supervision of technicians and programmers.
Years: 1988 to 1988 Employer: University of Toronto Title: Rosenstadt Professor (visiting) Department: Faculty of Pharmacy Responsibilities: Experiments using the multiple indicator dilution method and mathematical analysis of the results
Years: 1971 to 1985 Employer: Ludwig-Maximilian University Munich Title: Scientific Assistant/Research Scientist Department: Physiological Chemistry Responsibilities: Experimental work on the biogenesis of mitochondria; Experimental work, modeling and simulation of haptic tranport and metabolism; Programming of simulation software in Fortran and Algol; seminars and experimental workshps in biochemistry for pre-clinical medical students.

Government Experience

Years Agency Role Description
Years: 1994 to Present Agency: National Institutes of Health Role: Ad-hoc reviewer Description: Reviewing applications for funding at the Respiratory and Applied Physiology Study Section
Years: 1999 to Present Agency: National Institutes of Health Role: Ad-hoc reviewer Description: Reviewing applications for funding at the General Medicine Special Study Section.

International Experience

Years Country / Region Summary
Years: 1966 to 1967 Country / Region: Venezuela Summary: Experimental work in heterogenic catalysis for diploma thesis

Career Accomplishments

Associations / Societies
American Physiological Society, Microcirculatory Society
Licenses / Certifications
1982 Habilitation (Expertmed.habil.) in physiological chemistry at the Medical Faculty, University of Munich
Awards / Recognition
1988 Rosenstadt Professor of the University of Toronto (visiting)

1985–1987 Deutsche Forschungsgemeinschaft Senior Research Fellow
Publications and Patents Summary
63 publications in peer-reviewed scientific journals, 15 book chapters

Language Skills

Language Proficiency
German Geman is the Expert's first language and the language of his education
French Expert has learned French as a child and is using it daily as a resident of Quebec
Greek Greek is the expert's mother tongue. Expert has translated technical texts from Greek to English.
Spanish Expert used Spanish during his year-long visit to Venezuela including for work.

Fields of Expertise

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