Expert Details
Biomedical and Pharmacokinetic Modeling and Programming
ID: 723721
Canada
research in the uptake and metabolism of substrates using the perfused rat liver and the dog liver in vivo, using mainly the multiple indicator technique.
Expert performed experimental work pertaining to the uptake and metabolism of drugs and substrates in the whole organs (mainly perfused rat liver and dog live in vivo) using the multiple-indicator dilution technique. This included the preparation of radioactive tracers to be applied to the organ and analysis of blood samples by
ion-exchange chromatography, gamma spectroscopy and liquid scintillation spectroscopy. Expert has analyzed these results using mathematical models including mass transport and metabolic transformation. Expert has also analyzed pharmacokinetic data for several contract research organizations.
Expert has written and applied specialized software for the simulation of mass transport and metabolism. This software was used for the evaluation of experiments using mainly the multiple indicator technique, a method for
investigation uptake and transport of substances in whole organs by means of radioactive tracers. The software was written in FOTRAN (9000 lines). Expert participated actively in the development and maintenance of simulation
software "JSim", written in Java and FORTRAN. JSim is a Java-based simulation system for building quantitive numeric models and analyzing them with respect to experimental reference data. Expert has knowledge of most major programming languges.
Array
Programming of software for evaluation of enzyme kinetics for a research contract organizationEvaluation of pharmacokinetic data for two research contract organizations
Education
| Year | Degree | Subject | Institution |
|---|---|---|---|
| Year: 1971 | Degree: Dr.rer.nat (PhD equivalent) | Subject: Biochemistry | Institution: Ludwig-Maximilian-Univ Munich |
| Year: 1968 | Degree: Diplom (MSc equivalent) | Subject: Chemistry | Institution: Ludwig-Maximilian-Univ Munich |
Work History
| Years | Employer | Title | Department |
|---|---|---|---|
| Years: 1985 to Present | Employer: Undisclosed | Title: Medical Scientist/Associate Professor | Department: Research Institute |
Responsibilities:Experimental work in radioactive tracers, modeling and simulation of haptic tranport and metabolism. Supervision of technicians and programmers. |
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| Years | Employer | Title | Department |
| Years: 1988 to 1988 | Employer: University of Toronto | Title: Rosenstadt Professor (visiting) | Department: Faculty of Pharmacy |
Responsibilities:Experiments using the multiple indicator dilution method and mathematical analysis of the results |
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| Years | Employer | Title | Department |
| Years: 1971 to 1985 | Employer: Ludwig-Maximilian University Munich | Title: Scientific Assistant/Research Scientist | Department: Physiological Chemistry |
Responsibilities:Experimental work on the biogenesis of mitochondria; Experimental work, modeling and simulation of haptic tranport and metabolism; Programming of simulation software in Fortran and Algol; seminars and experimental workshps in biochemistry for pre-clinical medical students. |
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Government Experience
| Years | Agency | Role | Description |
|---|---|---|---|
| Years: 1994 to Present | Agency: National Institutes of Health | Role: Ad-hoc reviewer | Description: Reviewing applications for funding at the Respiratory and Applied Physiology Study Section |
| Years: 1999 to Present | Agency: National Institutes of Health | Role: Ad-hoc reviewer | Description: Reviewing applications for funding at the General Medicine Special Study Section. |
International Experience
| Years | Country / Region | Summary |
|---|---|---|
| Years: 1966 to 1967 | Country / Region: Venezuela | Summary: Experimental work in heterogenic catalysis for diploma thesis |
Career Accomplishments
| Associations / Societies |
|---|
| American Physiological Society, Microcirculatory Society |
| Licenses / Certifications |
|---|
| 1982 Habilitation (Expertmed.habil.) in physiological chemistry at the Medical Faculty, University of Munich |
| Awards / Recognition |
|---|
| 1988 Rosenstadt Professor of the University of Toronto (visiting) 1985–1987 Deutsche Forschungsgemeinschaft Senior Research Fellow |
| Publications and Patents Summary |
|---|
| 63 publications in peer-reviewed scientific journals, 15 book chapters |
Language Skills
| Language | Proficiency |
|---|---|
| German | Geman is the Expert's first language and the language of his education |
| French | Expert has learned French as a child and is using it daily as a resident of Quebec |
| Greek | Greek is the expert's mother tongue. Expert has translated technical texts from Greek to English. |
| Spanish | Expert used Spanish during his year-long visit to Venezuela including for work. |
Fields of Expertise
biochemistry, biochemical research, metabolism, pharmacokinetics, drug development, drug metabolism, application software, FORTRAN programming language, Java, Macintosh programming, simulation software, ALGOL programming language, computer spreadsheet, Microsoft Visual Basic, UNIX application, pharmacokinetic modeling, programming, World Wide Web application, drug metabolite, fungal metabolism, carbohydrate metabolism, computer software