Expert Details

Expert in Carbohydrate Chemistry, Neoglycoconjugates, Conjugate Vaccines, Oligosaccharides, Glycoconjugates

Expert ID: 716104 Maryland, USA

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Expert is an internationally recognized authority in carbohydrate chemistry. With over 30 years of hands-on experience in this field, he is considered among the top experts in synthetic carbohydrate chemistry in the world. Among Expert's most important achievements is his work involving regulated syntheses of many biologically important complex carbohydrates, such as oligosaccharides and fluorosugars. Having designed and executed a variety of carbohydrate syntheses, Expert has published over two hundred scientific papers in these fields. Despite many managerial and supervisory duties, he manages to spend part of his day doing what he likes most: working in his chemical laboratory. During his long and successful career, Expert has acquired considerable experience in the crystallization of sugars and carbohydrate derivatives on a very small scale. He is also an expert in many instrumental techniques related to, and indispensable in synthetic carbohydrate chemistry. He is well recognized by his peers, which is best documented by the many invitations he has received to give seminars at scientific symposia or academic institutions.


Expert has worked extensively with a variety of saccharides (sugars, carbohydrates). He can answer in-depth questions on the chemistry and structure determination of, monosaccharides, oligosaccharides and polysaccharides. He also has experience with crystallization of sugars and their derivatives at the microscale level.

Expert is an internationally recognized expert on the chemical synthesis of oligosaccharides. During his career, which spans some thirty years, Expert has designed and executed syntheses of a large number of oligosaccharides. These are described in over one hundred papers published in international journals. Many of the oligosaccharides he has synthesized are fragments of 0-polysaccharides of bacterial pathogens. He and his colleagues synthesize oligosaccharides to be used to study interactions of carbohydrate antigens and biologically active proteins, such as immunoglobulins. He is a master of blocking strategies in carbohydrates, which helps him in manipulating their hydroxyl groups and, eventually, turn out complicated derivatives he and his colleagues use to satisfy their scientific curiosity. The recognition Expert has received by his peers is best represented by the invitation to organize a recent international symposium on synthetic oligosaccharides held during an ACS meeting. He edited a book on synthetic oligosaccharides, published by the American Chemical Society as Volume 560 of its Symposium Series.

Expert is also an expert in separation and instrumental techniques related to synthetic carbohydrate chemistry, such as thin-layer and preparative liquid chromatography, and nuclear magnetic resonance spectroscopy. He is familiar with sophisticated one and two-dimensional NMR techniques and is able to choose the technique most suitable to solving a structural problem that may arise.


As an internationally recognized authority on synthetic carbohydrate chemistry, Expert has extensive experience in designing and executing multi-step syntheses of complex carbohydrate derivatives. The success of this work depends greatly on the ability of the chemist to manipulate hydroxyl groups in carbohydrates in such a way that the compatibility of blocking groups with various chemistries involved in a multi-step process not be compromised. Complex molecules resulting from each chemical manipulation have to be isolated in pure state and their structure has to be verified. Consequently, Expert has gained expertise in the associated separation and instrumental techniques.


Expert may consult nationally and internationally, and is also local to the following cities: Baltimore, Maryland - Frederick, Maryland - Gaithersburg, Maryland - Bowie, Maryland - Richmond, Virginia - Alexandria, Virginia - Wilmington, Delaware - Lancaster, Pennsylvania

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Education

Year Degree Subject Institution
Year: 1968 Degree: Post-Doctoral Work Subject: Organic Chemistry, Carbohydrate Chemistry, Polysaccharide Chemistry Institution: Purdue University, Department of Biochemistry
Year: 1967 Degree: PhD Subject: Organic Chemistry, Wood Chemistry Institution: Slovak Academy of Sciences, Inst. of Chem.
Year: 1962 Degree: MS Subject: Wood Chemistry Institution: Slovak Technical University - Czechoslovakia

Work History

Years Employer Title Department Responsibilities
Years: 1983 to Present Employer: Undisclosed Title: Research Chemist, Principal Investigator Department: NIDDK, LMC, Section on Carbohydrates Responsibilities: Expert's primary responsibilities are to design, supervise and execute research in carbohydrate chemistry targeted towards development of conjugate vaccines from synthetic fragments (antigenic oligosaccharides) of bacterial LPS.
Years: 1981 to 1982 Employer: Bachem, Inc. Title: Group Leader Department: Responsibilities: At Bachem, Expert executed on and supervised the production of oligonucleotides for machine synthesis of DNA fragments.
Years: 1969 to 1981 Employer: Institute of Chemistry, Slovak Academy of Sciences Title: Senior Researcher Department: Responsibilities: He designed, executed and supervised research in synthetic carbohydrate chemistry.

Government Experience

Years Agency Role Description
Years: 1983 to Present Agency: HHS, National Institute of Health Role: Scientist Description: Expert conducts research towards development of conjugate vaccines from synthetic fragments of bacterial polysaccharides.

Career Accomplishments

Associations / Societies
Expert is a member of Editorial Boards for Carbohydrate Research and the Journal of Carbohydrate Chemistry.
Awards / Recognition
In 1997, Expert received the Director's Award for advances in synthetic organic chemistry that have made a significant impact on the development of polysaccharide-based vaccines against cholera and shigella infections. He was also listed in the 1981-83 editions of Who's Who in the World and the 1985 Edition of Who's Who in Frontiers of Science and Technology.
Publications and Patents Summary
Expert has several patents and over 200 scientific papers in international scientific journals. He edited Vol. 560 of ACS Symposium Series: "Synthetic Oligosaccharides," and has written several chapters in monographs dealing with carbohydrate chemistry.

Additional Experience

Training / Seminars
Expert is able to give seminars on various topics dealing with carbohydrate chemistry.
Vendor Selection
He has experience locating vendors of complex carbohydrate derivatives, and
carbohydrate literature.
Other Relevant Experience
It is a well-known fact that an hour in a library can save a chemist a month of work in the laboratory. Thirty years of hands-on experience in carbohydrate chemistry and editorial work for a number of international and national scientific journals have made Expert an expert in the literature related to carbohydrates. He is familiar with journals, monographs, and series of books dealing with carbohydrate chemistry. As such, he can be very helpful in assisting individuals in their literature searches and in directing them to the proper source of information in a time-saving manner.

Expert completed a training management program in the chemical synthesis of oligonuleotides at City of Hope Research Institute, Duarte, CA in 1981.

Language Skills

Language Proficiency
Slovak, Hungarian A native of Czechoslovakia, Expert's first language is Slovak. He is also conversant in Hungarian.
English He speaks fluent English.
German, Russian Years back, Expert used to be quite fluent in both languages. Now his communication skills in German and Russian are a bit rusty.

Fields of Expertise

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