Expert Details

Expert in Chemical Biology, Medicinal Chemistry, Drug Discovery, Cancer Pharmacology, Hypoxia

Expert ID: 729938 United Kingdom

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A major aspect of Expert's research is focused on how to circumvent or exploit resistance mechanisms by the development of tumour-selective agents targeting abnormal enzymatic expression in cancer tissues. He has had a long-standing interest in certain heterocyclic aromatic pharmacophores for development of tumour-selective prodrugs, which work has led to 4 publications, the filing of 4 patents and two licensing deals (Somanta Ltd, Access Pharmaceuticals). Expert has also explored chromophores for the synthesis of DNA probes with unique fluorescence properties with wide applications in routine and research laboratories utilising flow cytometry and fluorescence imaging methods (www.biostatus.com/). At ICT he has been instrumental as a team leader in driving a new research project concerning the development of multistep synthesis of reengineered natural products including the duocarmycins as potential substrates for cytochromes P450 tumour-selective activation (this technology has recently been acquired by Incanthera Ltd (http://www.incanthera.com/). Other research projects concern the function and expression of aldehyde dehydrogenases (ALDHs), aldo-keto reductases (AKRs), and cytochrome P450 enzymes in cancer stem cells and solid tumors.

Over a 10-year period at ICT, Expert has been involved in > £6 million from various sources including pharmaceutical companies, research councils and cancer charities. In 2005/06 he was awarded a Bioscience Yorkshire Enterprise Fellowship, which allowed him to accumulate knowledge on knowledge transfer technology, intellectual property & set up of spin out companies. His network is global and works with experts of international repute in many European countries, China, India and USA. Via the award-winning "Bradford China Science Bridges" (http://www.bradford.ac.uk/science-bridges-china/) he has gained expert knowledge of how to operate in China and has established key links with a number of highly-rated universities in China. He is a member of UK-China Advanced Materials Research Institute (AMRI) http://www.polyeng.com/AMRIJan2013/AMRI/Welcome.html/.

In addition to his research and teaching commitments in drug discovery, he has served as a committee member of the British Association for Cancer Research (BACR) and has for a number of years been involved in AACR's Chemistry in Cancer Research working group; at present he serves as the Chair of the CICR Editorial Board. He is currently visiting professor at the chemical engineering school École Supérieure de Chimie Organique et Minérale (ESCOM, Compiegne, France) and the Department of Science and Drug Technologies, University of Torino (Italy).

In summary, Expert has more than 15 years of experience of working at the chemistry/biological interface including lab experience in synthetic chemistry, cell culture, metabolism investigations & drug interaction studies with DNA or enzymes.

Consultant: Somanta Ltd, Access Pharmaceuticals
(Alchemix and Prodrax technology)
Consultant: Biostatus Ltd
(Molecular fluorescent probes)
Consultant: Incanthera Ltd
(Duocarmycin chemotoxins)

Education

Year Degree Subject Institution
Year: 2002 Degree: PhD Subject: Synthetic Organic & Medicinal Chemistry Institution: UCL School of Pharmacy, London, UK
Year: 1998 Degree: BEng Subject: BEng Chemical Engineering & Biotechnology Institution: University of Southern Denmark

Work History

Years Employer Title Department Responsibilities
Years: 2005 to Present Employer: Undisclosed Title: Senior Lecturer in Chemical Biology Department: Institute of Cancer Therapeutics Responsibilities: (i) Expert' current supervision/line-management includes: 3 PostDocs, 1 visiting Research Fellow, 4 PhD students, 2 Industrial Placement students & 3 MSc/MChem students.
(ii) Expert is the co-ordinator of External Undergraduate Research Training Placements.
(iii) He gives lectures to undergraduate & postgraduate students in Drug Discovery & Cancer Pharmacology
(iv) He is the CSO of ICT China Operations
(v) He is the Team Leader of YCR Programme funded activities
Years: 2002 to 2005 Employer: UCL School of Pharmacy, London Title: PostDoc Department: Responsibilities: Investigator on a research project concerning Drug Design, Synthesis & Biological Evaluation.

Career Accomplishments

Associations / Societies
The Asia-Pacific Association of Medical Research (APAMR, 2015); Bradford Institute for Health Research (2009); Royal Society of Chemistry (RSC, 2006); RSC Interest Groups: Biological & Medicinal Chemistry Sector
& Bio-Organic Group (2012); American Chemical Society (ACS, 2006); ACS Medicinal Chemistry Division (2006); American Association for Cancer Research (AACR, 2004); AACR Chemistry in Cancer Research Working Group (2006); AACR Tumor Microenvironment Working Group (2013); British Association for Cancer Research (BACR, 1998); European Association for Cancer Research (EACR, 1998)
Professional Appointments
Chair, CICR Editorial Board (AACR, 2012-2016); British Association for Cancer Research (BACR) executive committee member: 2008-2011;
BACR Membership Services & Financial Sub-Committee 2008-2011;
Past Committee member, Young Chemists in Cancer Research (AACR): 2009-2011.
Awards / Recognition
UoB Vice-Chancellor's Awards for Outstanding Achievement (2015), Bradford Science Bridges China; Royal Society Mobility Award (2010) Bioscience Yorkshire Enterprise Fellowship (2005)
Publications and Patents Summary
Expert has 26 publications, 1 book chapter and 4 patents.

Additional Experience

Expert Witness Experience
Expert has experience with carrying out work for lawyers associated with a court case on an antidepressant drug. While working as a Research Fellow at the UCL School of Pharmacy (London) in 2002-05, Expert was involved in investigating certain properties of an antidepressant drug. The data obtained by Expert was used to settle a court case related to IP protection by a major pharmaceutical company.
Training / Seminars
Expert contributes with teaching to:
(i) Undergraduate pharmacy students
(ii) MSc students in Drug Discovery (Module leader)
(iii) MSc in Cancer Pharmacology (Module Leader)
(iv) MSc in Safety Pharmacology
(v) Chemistry in Drug Discovery workshop (ESCOM, France)
(vi) Cancer Drug Discovery workshop (University of Turin)
Marketing Experience
Expert daily work in academic drug discovery and through his work he has weekly contact with biotech companies, which means that he has a good insight in translating innovative ideas to commercial viable products.
Other Relevant Experience
(i) Synthesis of hit/lead compounds
(ii) Interrogation of investigational compounds in biochemical or cellular based assays
(iii) Tumour penetration of hit/lead or clinically used agents

Language Skills

Language Proficiency
Danish Expert is Danish and spent the first 24 years of his life in Denmark.

Fields of Expertise

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