Expert Details

Expert in Cough Medicine, Smoke Effects on the Lungs, Vivo Assessment of Airway Clearance, etc.

Expert ID: 715926 Canada

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Expert has expertise in mucus rheology, coughing and cough clearance. His research in mucology involves the study of airway surface fluid (ASF) and how it contributes to lung defense. ASF, the secretory product of the respiratory tract, is composed of water, carbohydrates, proteins, and lipids. It provides a protective milieu for the airways; its composition and physical characteristics allow for normal ciliary activity and airway hygiene. ASF is transported from the airways of the lung by airflow and mucociliary clearance. When disruption of normal secretory or mucociliary clearance processes occurs, abnormal respiratory secretions can impair pulmonary function, reduce lung defenses, and increase the risk for infection and possibly neoplasia.

He has also studied the basic mechanisms involved in cough clearance using a simulated cough machine. Clinical studies involve the collection and in vitro analysis of mucus from patients with various lung diseases and different treatments. He has focused some of his research on chronic bronchitis, asthma, lung cancer and cystic fibrosis, in all of which mucus dysfunction plays a role. He is also interested and has experience in the in vivo assessment of airway clearance and bioelectric properties.

Finally, since mucus clearance is promoted both by ciliary action and by airflow or cough, he has complemented his investigations by studying mechanical models of cough and isolated epithelial preparations, as well as mathematical analysis of the interaction between airflow, ciliary movement and mucus transport.

Expert developed the frog palate assay as a means of evaluating the ciliary clearability of mucus gels. In addition, working with a magnetic microrheometer, he was able to characterize the properties of respiratory tract mucus, as well as monitor the changes in mucus viscoelasticity in experimental manipulations.

Expert's major research interests are in the field of epithelial defense mechanisms, particularly as they relate to lung diseases involving mucociliary dysfunction. He is also interested in other organ systems where mucus is present, e.g. gastrointestinal and cervical epithelia. In cystic fibrosis, his recent research has related to the abnormal regulation of airway fluid. It has included studies on lung transplantation and on the pharmacoregulation of the ion transport defect. Expert has also been studying the role of neuropeptides in epithelial function, which relates particularly to asthma. His most recent research interests include pulmonary surfactants and mucus clearance, effect of proteases on airway secretion, and therapy for cystic fibrosis, using novel agents such as hypertonic saline and oligosaccharides.

With regard to smoking and lung cancer, Expert has been exploring the cytoprotective role of mucus and the factors which may cause its breakdown. He developed a model of experimental chronic bronchitis involving exposure of dogs to cigarette smoking via a tracheostomy.

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Education

Year Degree Subject Institution
Year: 1973 Degree: PhD Subject: Polymer Chemistry Institution: McGill University, Montreal, PQ
Year: 1968 Degree: BSc Subject: Honors Chemistry Institution: McMaster University, Hamilton, ON

Work History

Years Employer Title Department Responsibilities
Years: 1990 to Present Employer: Undisclosed Title: Professor Department: Department Of Medicine, Pulmonary Division Responsibilities: Expert is a professor, researcher and a Medical Research Scholar at the University where he teaches.
Years: 1996 to 1997 Employer: McGill University Title: Visiting Professor Department: Meakins - Christie Labs Responsibilities:
Years: 1986 to 1987 Employer: University of Freiburg, Germany Title: Guest Professor Department: Robert Koch Klinik Responsibilities:
Years: 1985 to Present Employer: Undisclosed Title: Co-Director Department: Pulmonary Research Group Responsibilities:
Years: 1985 to Present Employer: Undisclosed Title: Research Associate Department: Responsibilities:
Years: 1980 to 1985 Employer: Royal Victoria Hospital, Montreal Title: Medical Scientist Department: Responsibilities:
Years: 1980 to 1985 Employer: McGill University Title: Assistant Professor Department: Department of Medicine Responsibilities:

Career Accomplishments

Associations / Societies
Expert is a member of the Chemical Institute of Canada, the Canadian Society for Clinical Investigation, the Society of Rheology, the American Physiological Society, the American Thoracic Society, the American College of Chest Physicians, and the International Society of Biorheology.
Awards / Recognition
He has received several honors including renewal as a Medical Research Scholar (1990) and appointments as Chairman of both the Canadian Thoracic Society Research Committee and the Lung Association Medical and Scientific Council.
Publications and Patents Summary
Expert has published more than 125 papers, most of them addressing mucus rheology and clearance.

Language Skills

Language Proficiency
English and French Expert is fluent in English and French.
German He reads German.

Fields of Expertise

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