Expert in Cough Medicine, Smoke Effects on the Lungs, Vivo Assessment of Airway Clearance, etc.
Expert ID: 715926 Canada
He has also studied the basic mechanisms involved in cough clearance using a simulated cough machine. Clinical studies involve the collection and in vitro analysis of mucus from patients with various lung diseases and different treatments. He has focused some of his research on chronic bronchitis, asthma, lung cancer and cystic fibrosis, in all of which mucus dysfunction plays a role. He is also interested and has experience in the in vivo assessment of airway clearance and bioelectric properties.
Finally, since mucus clearance is promoted both by ciliary action and by airflow or cough, he has complemented his investigations by studying mechanical models of cough and isolated epithelial preparations, as well as mathematical analysis of the interaction between airflow, ciliary movement and mucus transport.
Expert developed the frog palate assay as a means of evaluating the ciliary clearability of mucus gels. In addition, working with a magnetic microrheometer, he was able to characterize the properties of respiratory tract mucus, as well as monitor the changes in mucus viscoelasticity in experimental manipulations.
Expert's major research interests are in the field of epithelial defense mechanisms, particularly as they relate to lung diseases involving mucociliary dysfunction. He is also interested in other organ systems where mucus is present, e.g. gastrointestinal and cervical epithelia. In cystic fibrosis, his recent research has related to the abnormal regulation of airway fluid. It has included studies on lung transplantation and on the pharmacoregulation of the ion transport defect. Expert has also been studying the role of neuropeptides in epithelial function, which relates particularly to asthma. His most recent research interests include pulmonary surfactants and mucus clearance, effect of proteases on airway secretion, and therapy for cystic fibrosis, using novel agents such as hypertonic saline and oligosaccharides.
With regard to smoking and lung cancer, Expert has been exploring the cytoprotective role of mucus and the factors which may cause its breakdown. He developed a model of experimental chronic bronchitis involving exposure of dogs to cigarette smoking via a tracheostomy.
|Year: 1973||Degree: PhD||Subject: Polymer Chemistry||Institution: McGill University, Montreal, PQ|
|Year: 1968||Degree: BSc||Subject: Honors Chemistry||Institution: McMaster University, Hamilton, ON|
|Years: 1990 to Present||Employer: Undisclosed||Title: Professor||Department: Department Of Medicine, Pulmonary Division||Responsibilities: Expert is a professor, researcher and a Medical Research Scholar at the University where he teaches.|
|Years: 1996 to 1997||Employer: McGill University||Title: Visiting Professor||Department: Meakins - Christie Labs||Responsibilities:|
|Years: 1986 to 1987||Employer: University of Freiburg, Germany||Title: Guest Professor||Department: Robert Koch Klinik||Responsibilities:|
|Years: 1985 to Present||Employer: Undisclosed||Title: Co-Director||Department: Pulmonary Research Group||Responsibilities:|
|Years: 1985 to Present||Employer: Undisclosed||Title: Research Associate||Department:||Responsibilities:|
|Years: 1980 to 1985||Employer: Royal Victoria Hospital, Montreal||Title: Medical Scientist||Department:||Responsibilities:|
|Years: 1980 to 1985||Employer: McGill University||Title: Assistant Professor||Department: Department of Medicine||Responsibilities:|
|Associations / Societies|
|Expert is a member of the Chemical Institute of Canada, the Canadian Society for Clinical Investigation, the Society of Rheology, the American Physiological Society, the American Thoracic Society, the American College of Chest Physicians, and the International Society of Biorheology.|
|Awards / Recognition|
|He has received several honors including renewal as a Medical Research Scholar (1990) and appointments as Chairman of both the Canadian Thoracic Society Research Committee and the Lung Association Medical and Scientific Council.|
|Publications and Patents Summary|
|Expert has published more than 125 papers, most of them addressing mucus rheology and clearance.|
|English and French||Expert is fluent in English and French.|
|German||He reads German.|
Fields of Expertise
mucus, mucus rheology, cough clearance, pulmonary medicine, bronchial disease, gel rheological measurement, lung disease, respiratory physiology, viscoelasticity, tobacco smoke human health effect, respiratory physiology, viscoelasticity, cough medicine, chronic bronchitis, cough, airway management, assay development, respiratory care, mucous membrane, lung cancer, multiphase flow measurement, airstream, epithelium, mixed flow, liquid rheological measurement, protease, polymer crosslinking, cold pharmacology, thixotropy, surgical transplantation, rheology, respiratory disease, non-Newtonian liquid flow, glycoprotein, gel, drug therapy, cystic fibrosis, cigarette smoke, asthma, antihistamine, animal model, air flow