Expert Details

Expert in DNA Sequencing: Next-Generation Sequencing (NGS)

Expert ID: 731456 United Kingdom

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Expert is the VP of Sequencing at a major research institute. He is involved with many aspects of the Illumina production sequencing pipeline (~ 30 HiSeq instruments). Until recently, he managed the entire instrument pipeline. As one of the world's largest next-generation DNA sequencing facilities, his research institute performs medically relevant experiments in human genome variation analysis (including the 1000 Genomes Project), cancer genome resequencing (ICGC), pathogen studies, transcriptomics, microRNA analysis, etc. His newest role involves assessment, acquisition, testing and development of all current and future DNA sequencing technologies; currently supported platforms include MiSeq, Pacbio and Ion Torrent in his R+D group and potentially an Oxford Nanopore instrument soon. As the local expert on NGS technology, he is very familiar with all the players in next-generation sequencing including Illumina, Life Technologies, Oxford Nanopore Technologies, Genia, Pacific Biosciences and Complete Genomics. He was the Senior Director of Research at a cutting edge biotech firm and advises two early-stage next-generation sequencing companies.

Lastly, he provides consulting services for all the major players in expert consultancy, so he is very experienced in all aspects of telephone consulting for both investors and analysts, not the least being adherence to regulatory restrictions.


He has consulted for all the large expert networks on the DNA analysis business including about 150 phone calls to investors and analysts at many of the top firms.Patent advice to lawyers and companies - claims analysis, prosecution, interference, etc.

Expert may consult nationally and internationally, and is also local to the following cities: New York, New York - Yonkers, New York - Newark, New Jersey - Jersey City, New Jersey - Paterson, New Jersey - Elizabeth, New Jersey - Bridgeport, Connecticut - New Haven, Connecticut - Hartford, Connecticut - Philadelphia, Pennsylvania

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Education

Year Degree Subject Institution
Year: 1991 Degree: Ph.D. Subject: Bioengineering Institution: University of Utah
Year: 1979 Degree: BS Subject: Physics and math Institution: University of California, Santa Cruz, CA

Work History

Years Employer Title Department Responsibilities
Years: 2014 to Present Employer: Undisclosed Title: VP of Sequencing Department: Operations Responsibilities: Expert runs the production sequencing operation for one of the largest sequencing facilities. He also manages the clinical operations and the technology innovation (R+D) teams.
Years: 2008 to 2014 Employer: The Wellcome Trust Sanger Institute Title: Head of Research and Development (R+D) Department: Sequencing Responsibilities: He directs a large R+D group that delivers custom molecular biology tools for next-generation DNA sequencing; testing and development of early access sequencing instruments.
Years: 2006 to 2007 Employer: The Dolomite Centre, Ltd., U.K. Title: Chief Technology Officer (CTO) Department: Responsibilities: Set-up of a new entity using UK Department of Trade and Industry funding. Dolomite's goal is to develop a glass and quartz microfabrication and microfluidics design and development centre unique in the UK. Business development and management of key projects in all areas of science and especially focussing on applications in PCR, DNA analysis and sequencing.
Years: 2000 to 2006 Employer: Solexa, Ltd. U.K Title: Senior Director of Research Department: Responsibilities: Contributed to the development of Solexa's first product through to early-access launch in 2006. Other responsibilities included optimisation of DNA sequencing protocols and oversight of next-generation technologies; enhanced fluorescent detection methods, improved instrumentation and advanced biochemical strategies for DNA sequencing.
Years: 1998 to 2000 Employer: Center for Genomics Res. Karolinska Inst. Title: Unit Coordinator (Genomics Technologies Unit) and Director of the Microarray Core Facility Department: Center for Genomics Research Responsibilities: Microchip-based DNA analysis; microfluidic system design; functional genomics; design and development of automated capillary electrophoresis instrumentation; breast-cancer diagnostics.
Years: 1991 to 1998 Employer: Human Genetics, Univ. of Utah Title: Research Assistant Professor, formerly Post-doctoral Research Associate Department: Department of Human Genetics Responsibilities: Use of microfluidic technology and microfabrication to solve problems in molecular biology; automated DNA sequencing instrumentation; DNA-based diagnosis of genetic diseases; analytical chemistry for genomics applications; polymer and surface chemistry. Capillary fluidics-based diagnostics; DNA-sequencing technology development.

Career Accomplishments

Associations / Societies
SAB member for 2 next-generation sequencing companies (ZS Genetics and Noblegen)



Publications and Patents Summary
He has 44 publications and is an inventor on 13 issued patents

Additional Experience

Expert Witness Experience
I have evaluated patents for legal clients and prepared technical reports. But have no direct trial experience.
Training / Seminars
Wellcome Trust Advanced Course in Next-Generation DNA sequencing
Vendor Selection
Have worked with all the main instrument providers for DNA sequencing
Marketing Experience
Market drivers, funding environment and future trends in next-generation sequencing
Other Relevant Experience
Investor and Analyst consultations on a regular basis.

Fields of Expertise

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