Expert Details

Expert in Drug Delivery Using MEMS, Ultrasound, Electroporation and Other Engineering Technologies

Expert ID: 722843 Georgia, USA

Request Expert

Expert has been the founder of two novel fields of transdermal drug delivery and has led a paradigm shift from chemical to physical methods to enhance skin permeability. He published the first paper establishing electroporation of skin. Using this approach, short, high-voltage electric pulses are applied to the skin to rearrange the molecular structures that form the skin barrier by a mechanism related to dielectric breakdown of capacitors. Expert also invented another physical method to increase transdermal transport and published the first paper on microneedles in 1998. Expert has intensively studied fundamental issues associated with mechanisms of drug transport across skin, skin-needle biomechanics, and avoidance of pain; and has pushed applications forward by developing novel microfabrication technology to make microneedles and new methods to deliver drugs in controlled and targeted ways.

Anther major topic of Expert’ research has been intracellular drug delivery using ultrasound and electroporation. Expert has intensively studied and produced by far the largest dataset establishing the relationship between acoustic and other experimental parameters and the effects of ultrasound on intracellular delivery and cell viability in vitro. He has also developed and patented novel feedback strategies based on acoustic and optical emissions produced during ultrasound exposure for real-time control of biological effects. Most significantly, he has elucidated the mechanism by which ultrasound acts on cells, where cavitation bubbles associated with ultrasound mechanically detach micron-scale sections of membrane from cells, which in turn actively reseal these wounds using endogenous lipid vesicles. Expert has also made important advances in electroporation of tissues and cells as a means to deliver molecules across cell membranes in a targeted manner. His work has produced the first studies of electroporation of polarized epithelium and tumor spheroids, which provides a critical link between in vitro cell suspensions and in vivo tissues. Expert also produced a set of widely applicable and validated mathematical expressions to predict conditions that optimize DNA transfection using electroporation.

Expert also works on drug delivery to the eye to model drug diffusion across ocular barrier tissues and to experimentally study drug delivery to the back of the eye. In addition to teaching a sophomore-level Chemical Process Principles class, Expert developed two new courses. He first developed “Effective Communication for Professional Engineering,” which emphasizes the skills needed to accomplish realistic workplace goals through oral and written communication. Expert’ second new course entitled “Drug Design, Development and Delivery” provides an integrated, interdisciplinary analysis of the design, development and delivery components of pharmaceutical science.

Expert may consult nationally and internationally, and is also local to the following cities: Atlanta, Georgia - Columbus, Georgia - Athens, Georgia - Macon, Georgia - Roswell, Georgia - Marietta, Georgia - Chattanooga, Tennessee

Request Expert

Education

Year Degree Subject Institution
Year: 1994 Degree: Ph. D. Subject: Chemical and Biomedical Engineering Institution: MIT
Year: 1988 Degree: B. S. Subject: Chemical Engineering Institution: Stanford University

Work History

Years Employer Title Department Responsibilities
Years: 1995 to Present Employer: Undisclosed Title: Associate Professor Department: School of Chemical and Biomolecular Engineering Responsibilities: Expert heads the Laboratory for Drug Delivery, which houses 12-15 graduate and postdoctoral researchers. He also teaches undergraduate and graduate courses on pharmaceuticals, technical communication, and engineering principles. He is the Director of the Center for Drug Design, Development and Delivery, with 25 faculty participants.

Government Experience

Years Agency Role Description
Years: 1995 to Present Agency: NIH, NSF, other Role: Grant Proposal Reviewer Description:

International Experience

Years Country / Region Summary
Years: 1994 to 1995 Country / Region: Asia, Africa, Latin America, and the Carribean Summary: Expert worked for ORBIS International developing and implementing a biomedical engineering training program in China, Myanmar (Burma), Sudan, Jamaica, El Salvador, and Peru.

Career Accomplishments

Professional Appointments
Expert serves on the: Editorial Advisory Board, Journal of Controlled Release;
Editorial Advisory Board, Pharmaceutical Research; Advisory Board, Center for Drug Delivery Research, Southern School of Pharmacy at Mercer University; Scientific Advisory Board, CytoDome, Inc.; and the Board of Directors, Redeon, Inc.
Awards / Recognition
He has received or has been named: the Young Investigator Award, Controlled Release Society; Curtis W. McGraw Research Award, American Society for Engineering Education; NSF/NIH Scholar-in-Residence at the National Institutes of Health, National Science Foundation; 40-Under-40 Rising Stars of 2001, Georgia Trend Magazine; Finalist, Coulter Award for Innovation and Entrepreneurship, The Wallace Coulter Foundation; BP/AMOCO Junior Faculty Teaching Excellence Award, Georgia Institute of Technology; Top 100 Young Innovator (TR100), Technology Review Magazine; Student Paper Competition Award, Advisor, Science Applications International Corporation; Junior Faculty Research Award, Sigma Xi Scientific Research Society, Georgia Institute of Technology Chapter; CAREER Young Investigator Award, National Science Foundation; Best Paper Award, Journal of Clinical Engineering; Outstanding Pharmaceutical Paper Award, Controlled Release Society; and the Outstanding Work in Transdermal Drug Delivery Award, Controlled Release Society.
Publications and Patents Summary
Expert has 70 journal publications, 85 invited presentation at conferences, companies and academia, and 100 conference abstracts.

Additional Experience

Expert Witness Experience
Expert has served as expert witness in the following cases:
1). Iomed v. Yanaki, et al., Third Judicial District Court, Salt Lake County, UT (Case No. 020903031); retained by defendant (Parsons Kinghorn Peters); provided an expert report on confidential information and trade secrets.
2). SpectRx, Inc. v. Non-Invasive-Monitoring Co. et al., American Arbitration Association, Atlanta, GA (Case No. 301600015400); retained by plaintiff (King & Spalding); provided an expert report, deposition, and testimony on interpretation of a license agreement and patents.
3). Retained by plaintiff (Thomas William Malone, P.C.); Began preparation of an expert report on medical device operation.
Other Relevant Experience
He has consulted for the following companies: CytoDome, Tucson, AZ; GMP Companies, Fort Lauderdale, FL; The Mentholatum Company, Ltd., Glasgow, Scotland; Corixa, Inc. Seattle, WA; The Washington Advisory Group, Washington, DC; Unilever Research U.S., Edgewater, NJ; Valentis, Inc., The Woodlands, TX; Redeon, Inc, Cambridge, MA; EKOS Corporation, Bothell, WA; Becton Dickinson, Franklin Lakes, NJ; Genetronics, San Diego, CA; ALZA Corporation, Palo Alto, CA; Genentech, Inc, South San Francisco, CA; Myanmar Ministry of Health, Yangon, Myanmar (Burma);
Pharmos Corporation, Rehovot, Israel; and Health Advances, Wellesley, MA.

Fields of Expertise

Request Expert

Dev Tool:

Request: expert/drug-delivery-using-mems-ultrasound-electroporation-and-other-engineering-technologies
Matched Rewrite Rule: expert/([^/]+)(?:/([0-9]+))?/?$
Matched Rewrite Query: experts=drug-delivery-using-mems-ultrasound-electroporation-and-other-engineering-technologies&page=
Loaded Template: single-experts.php