Expert in Drug Delivery Using MEMS, Ultrasound, Electroporation and Other Engineering Technologies
Expert ID: 722843 Georgia, USA
Anther major topic of Expert’ research has been intracellular drug delivery using ultrasound and electroporation. Expert has intensively studied and produced by far the largest dataset establishing the relationship between acoustic and other experimental parameters and the effects of ultrasound on intracellular delivery and cell viability in vitro. He has also developed and patented novel feedback strategies based on acoustic and optical emissions produced during ultrasound exposure for real-time control of biological effects. Most significantly, he has elucidated the mechanism by which ultrasound acts on cells, where cavitation bubbles associated with ultrasound mechanically detach micron-scale sections of membrane from cells, which in turn actively reseal these wounds using endogenous lipid vesicles. Expert has also made important advances in electroporation of tissues and cells as a means to deliver molecules across cell membranes in a targeted manner. His work has produced the first studies of electroporation of polarized epithelium and tumor spheroids, which provides a critical link between in vitro cell suspensions and in vivo tissues. Expert also produced a set of widely applicable and validated mathematical expressions to predict conditions that optimize DNA transfection using electroporation.
Expert also works on drug delivery to the eye to model drug diffusion across ocular barrier tissues and to experimentally study drug delivery to the back of the eye. In addition to teaching a sophomore-level Chemical Process Principles class, Expert developed two new courses. He first developed “Effective Communication for Professional Engineering,” which emphasizes the skills needed to accomplish realistic workplace goals through oral and written communication. Expert’ second new course entitled “Drug Design, Development and Delivery” provides an integrated, interdisciplinary analysis of the design, development and delivery components of pharmaceutical science.
Expert may consult nationally and internationally, and is also local to the following cities: Atlanta, Georgia - Columbus, Georgia - Athens, Georgia - Macon, Georgia - Roswell, Georgia - Marietta, Georgia - Chattanooga, Tennessee
|Year: 1994||Degree: Ph. D.||Subject: Chemical and Biomedical Engineering||Institution: MIT|
|Year: 1988||Degree: B. S.||Subject: Chemical Engineering||Institution: Stanford University|
|Years: 1995 to Present||Employer: Undisclosed||Title: Associate Professor||Department: School of Chemical and Biomolecular Engineering||Responsibilities: Expert heads the Laboratory for Drug Delivery, which houses 12-15 graduate and postdoctoral researchers. He also teaches undergraduate and graduate courses on pharmaceuticals, technical communication, and engineering principles. He is the Director of the Center for Drug Design, Development and Delivery, with 25 faculty participants.|
|Years: 1995 to Present||Agency: NIH, NSF, other||Role: Grant Proposal Reviewer||Description:|
|Years||Country / Region||Summary|
|Years: 1994 to 1995||Country / Region: Asia, Africa, Latin America, and the Carribean||Summary: Expert worked for ORBIS International developing and implementing a biomedical engineering training program in China, Myanmar (Burma), Sudan, Jamaica, El Salvador, and Peru.|
|Expert serves on the: Editorial Advisory Board, Journal of Controlled Release;
Editorial Advisory Board, Pharmaceutical Research; Advisory Board, Center for Drug Delivery Research, Southern School of Pharmacy at Mercer University; Scientific Advisory Board, CytoDome, Inc.; and the Board of Directors, Redeon, Inc.
|Awards / Recognition|
|He has received or has been named: the Young Investigator Award, Controlled Release Society; Curtis W. McGraw Research Award, American Society for Engineering Education; NSF/NIH Scholar-in-Residence at the National Institutes of Health, National Science Foundation; 40-Under-40 Rising Stars of 2001, Georgia Trend Magazine; Finalist, Coulter Award for Innovation and Entrepreneurship, The Wallace Coulter Foundation; BP/AMOCO Junior Faculty Teaching Excellence Award, Georgia Institute of Technology; Top 100 Young Innovator (TR100), Technology Review Magazine; Student Paper Competition Award, Advisor, Science Applications International Corporation; Junior Faculty Research Award, Sigma Xi Scientific Research Society, Georgia Institute of Technology Chapter; CAREER Young Investigator Award, National Science Foundation; Best Paper Award, Journal of Clinical Engineering; Outstanding Pharmaceutical Paper Award, Controlled Release Society; and the Outstanding Work in Transdermal Drug Delivery Award, Controlled Release Society.|
|Publications and Patents Summary|
|Expert has 70 journal publications, 85 invited presentation at conferences, companies and academia, and 100 conference abstracts.|
|Expert Witness Experience|
|Expert has served as expert witness in the following cases:
1). Iomed v. Yanaki, et al., Third Judicial District Court, Salt Lake County, UT (Case No. 020903031); retained by defendant (Parsons Kinghorn Peters); provided an expert report on confidential information and trade secrets.
2). SpectRx, Inc. v. Non-Invasive-Monitoring Co. et al., American Arbitration Association, Atlanta, GA (Case No. 301600015400); retained by plaintiff (King & Spalding); provided an expert report, deposition, and testimony on interpretation of a license agreement and patents.
3). Retained by plaintiff (Thomas William Malone, P.C.); Began preparation of an expert report on medical device operation.
|Other Relevant Experience|
|He has consulted for the following companies: CytoDome, Tucson, AZ; GMP Companies, Fort Lauderdale, FL; The Mentholatum Company, Ltd., Glasgow, Scotland; Corixa, Inc. Seattle, WA; The Washington Advisory Group, Washington, DC; Unilever Research U.S., Edgewater, NJ; Valentis, Inc., The Woodlands, TX; Redeon, Inc, Cambridge, MA; EKOS Corporation, Bothell, WA; Becton Dickinson, Franklin Lakes, NJ; Genetronics, San Diego, CA; ALZA Corporation, Palo Alto, CA; Genentech, Inc, South San Francisco, CA; Myanmar Ministry of Health, Yangon, Myanmar (Burma);
Pharmos Corporation, Rehovot, Israel; and Health Advances, Wellesley, MA.
Fields of Expertise
controlled-release drug delivery, dermal absorption, drug delivery, electrotransport drug delivery, iontophoresis, iontophoretic, ocular drug delivery, skin absorption, skin permeability coefficient, skin permeation, transdermal, transdermal drug delivery, transdermal patch, ultrasonic cell disruption, ultrasound biological application, human skin, biomedical application, ultrasound, membrane permeation, controlled-release oral drug delivery, medical injection process, jet injection, transdermal drug delivery pharmacokinetics, polymer drug-delivery method, polymer drug-delivery microsphere, controlled release, therapeutic device, parenteral drug delivery, biomedical instrumentation, ultrasound human health effect, topical drug, controlled-release drug delivery technology, ultrasound treatment, biomedical device, cell membrane biophysics, ultrasonics, ultrasonic bioengineering, skin, programmable drug delivery, oral drug delivery, medical device, buccal drug delivery, biophysics, biomedical engineering