Expert Details

Expert in Enzyme/Protein/Antibody Stabilization, Biosensor Development & Shelf-life, DNA Stability & Testing

Expert ID: 725797 United Kingdom

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He has to deal with evaluating new business ideas on a daily basis either via his new business or via his enzyme business.

A number of new stabilization systems have been incorporated into new product lines as a result of his entrepreneurship, as well as new business opportunities, including possible joint ventures and small company buy-outs.

He has a great deal of expertise in the immobilization of enzymes, proteins, antibodies, immunoassay and biosensor development.

His experience includes:

The immobilization of enzymes onto enzyme biosensors for extended use or for in vivo applications.

The reusability of enzyme based systems via immobilization protocols, applications being biocatalysts and enzyme based cleaning solutions.

The immobilization of antibodies onto surfaces typically for optical measurements of analyses.

The capture of toxins via immobilization regimes for eventual analysis.

He has extensive expertise in the stabilization of enzymes, proteins, peptides, antibodies and DNA molecules. He has been working in this particular field for the past 9 years. He has helped stabilize a large portfolio of proteins, the majority used for biosensor applications. He has extended the shelf-life of proteins in the Expert state and the solution state. Examples include dehydrogenate based systems including the co-factors. He has worked with labile mutant enzymes used in the defense sector, PCR components that required stability during a manufacturing process, solution stability of antibodies and DNA samples during transport, multiple cascade enzyme systems required for clinical chemistry applications, the stability of antibodies within lateral flow devices, the stabilization of enzymes within screen-printed/ink jetting inks and many more.

He has many years of experience in research and development. These include research in cardiac biochemistry and extend to the present day with his expertise in protein stabilization and immobilization.

He has run a multitude of such projects over the years in order to solve problems for clients with particular reference to the stability of proteins within their manufacturing process as well as their final devise or application.

All bound by confidentiality agreements

Education

Year Degree Subject Institution
Year: 1986 Degree: BSc Subject: Animal Physiology Institution: Queen Mary College London
Year: 1987 Degree: MSc Subject: Forensic Science Institution: Kings College London
Year: 1992 Degree: PHD Subject: Genetics Institution: University college London
Year: 2005 Degree: Postgraduate Diploma Subject: Business Enterprise & Development. Institution: University College Wales Newport
Year: 2005 Degree: Postgraduate Certificate Subject: Business Marketing Strategy Institution: Kellogg Graduate School of Management

Work History

Years Employer Title Department Responsibilities
Years: 2006 to Present Employer: Undisclosed Title: Managing Director Department: Responsibilities: He sets up new business. He is in charge of the day to day running of the business, dealing with customers, setting up new business partnerships, developing new product ranges and ensuring delivery of good service to customers.
Years: 1999 to 2015 Employer: Applied Enzyme Technology Ltd Title: Director Department: Responsibilities: He provided technical input into new and ongoing contracts, bringing in new business, reviewing product list and introducing new product lines, marketing strategy and management of current staff.
Years: 1993 to 1999 Employer: University of Leeds Title: Postdoc researcher Department: School of Biochemistry & Molecular Biology Responsibilities: He ran his own research into Cardiac Biochemistry. He was responsible for raising his own research grants, presenting research at large international conferences, publishing research and mentoring PhD students.
Years: 1997 to 1997 Employer: University of Maryland School of Medicine Title: Voluntary Faculty Member Department: Responsibilities: He ran his own research into Cardiac Biochemistry.
Years: 1990 to 1993 Employer: Royal London Hospital Title: Research Technician Department: Department of Hematology Responsibilities: He was a technician in paternity testing laboratory. He was responsible for all protein electrophoresis markers screening for disputed paternity cases.
Years: 1987 to 1990 Employer: Medical research Council Title: Research Assistant Department: Biochemical Genetics Unit Responsibilities: He carried out his own research for PhD funded by the Home Office Publishing research.
Years: 2015 to Present Employer: Undisclosed Title: Life Science Specialist Department: Biosensors Department Responsibilities: Repsonsible the testing and development of novel Graphene like materials for biosensor applications

International Experience

Years Country / Region Summary
Years: 2007 to 2007 Country / Region: USA Summary: He stabilized complex biosensor for clinical chemistry application.
Years: 2007 to Present Country / Region: USA Summary: He sourced and reformulated new enzyme source.
Years: 2008 to Present Country / Region: China Summary: He sourced and reformulated new enzyme source.
Years: 2008 to Present Country / Region: France Summary: He advised on new biosensor design and stability of final sensor materials.
Years: 2007 to 2007 Country / Region: Denmark Summary: He advised on the stability of a liquid enzyme formulation.

Career Accomplishments

Associations / Societies
He is a full member of the Forensic Science Society.
Professional Appointments
He is Managing Director of Polygenyn Ltd.
Publications and Patents Summary
He has 16 peer reviewed papers and a large number of abstracts and poster presentations. He has made a number of oral presentations at international conferences in cardiac biochemistry and biosensors.

Additional Experience

Training / Seminars
He helped develop and presented at 2 day Biosensor Workshops that have been held in San Diego, Boston, Florence Italy, Kenilworth UK & Bristol UK (2009).
Vendor Selection
These types of vendor supplier sourcing are carried out on a daily basis within the biosensor, biochemistry, biotechnology and DNA testing industries. He has expertise with locating competitors as well as customers within these industries and habitually has to work out how best to work with or collaborate with these companies. Other sources of great collaboration and knowledge come form the networking with a number of well known UK universities.
Marketing Experience
He is experienced in the problems of setting up a new company and running another business, setting up marketing strategies and developing new product lines. He is experienced in setting up contract research contracts and consulting within his field of expertise. Experience in setting up license agreements and royalty agreements. All of the above cover both European and US territories. He has technical expertise in protein stabilization. Shelf-life extension and operational stability. This applies to enzymes, antibodies, other proteins, DNA molecules. He has expertise of combining immobilization technology with protein stability. He has worked with small enterprises in new product development and large Blue Chip Companies that require improvements to production processes. Most of the applications of this technology have been used in the development of Biosensors, particularly blood glucose sensors. However, much expertise has also been applied to the environmental sectors, agrifood and diagnostics industries.
Other Relevant Experience
He also has expertise in sourcing enzymes and enzyme manufacturers. He has expertise in the DNA testing sector as is well aware of the problems involved in the accreditation of such services.

Language Skills

Language Proficiency
French He is a fluent French speaker.
Italian He has basic Italian language skills.

Fields of Expertise

entrepreneurship, enzyme immobilization, enzyme stability, research and development, haloperoxidase, commercialization, small business, business strategy, enzyme modification, new consumer product development, business management, protein-protein crosslinking, enzyme analysis, cleaning enzyme, biocatalysis, enzyme inactivation, enzyme inhibitor, oxidative enzyme, industrial enzyme, uricase, alkaline phosphatase, glyoxalase, medical laboratory, superoxide dismutase, luciferase, amylase, permease, cellulase, enzymatic wood degradation, enzyme activity assay, enzyme purification, rapid product development, enzyme-containing membrane, product manufacturing, reproductive genetics, protein biochemistry, clinical genetics, analytical biochemistry, isoenzyme, clinical enzymology, phosphatase, kinase, enzyme immunoassay, enzyme technique, human genetics, enzymatic catalysis, heat stable enzyme, metalloenzyme, biomedical product development, biochemical research, new product design, biotin-avidin technology, electrobiochemistry, product cost reduction, new product development, research and development management, catalase, immunochemistry, enzyme mechanism, peroxidase, research, marketing, innovation, genotype, cholinesterase, biochemical engineering, enzyme kinetics, enzyme technology, applied enzymology, polymerase, nuclease, DNA, enzyme, transferase, project management, oxidoreductase, lipase, ligase, isomerase, immobilized enzyme, hydrolase, heredity, genetics, industrial fermentation, esterase, enzymology, enzyme wastewater treatment, enzyme production, dehydrogenase, coenzyme, biotin, biotechnology, biochemistry, industrial biochemical process

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