Expert Details

Expert in Fermentation Technology: Media, Process Design, Development, Optimization, Technology Transfer, Scale Up to Commercial Scale Production

Expert ID: 736817 California, USA

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• Expert has more than 30 years of industrial (both biopharma and biotech) experience from research, pilot plant to commercial production, including MCB and WCB preparation, media and process design and development, optimization, scale-up, technology transfer, and production in the US, Canada, and Mexico.

• Expert Successfully designed and developed novel Delta-V controlled DO/pH Stat (for defined media) and RQ feeding (for complex media) strategies and solved theoretical and practical feeding control problems. Based on these strategies, a lot of fermentation research projects might only be an experiment here.

• Expert Independently completed and supervised more than 60 projects with 15 microorganisms. Of those commercial products, seven products were one-step scaled up from 30 liters Lab scale to 93/190KL commercial-scale production. Furthermore, NONE of their very first engineerings runs failed. Also, based on available information, Expert was the first one to scale up three strains (Schizosaccharomyces pombe, Pseudomonas fluorescent, and Pichia pastors) to 190KL commercial scale 10-15 years ago.

• Expert has experience in setting up fermentation lab and pilot plant.


Year Degree Subject Institution
Year: 1990 Degree: Ph.D. Subject: Artificial Cells with Multienzyme Systems Institution: McGill University
Year: 1982 Degree: M.Sc. Subject: Extracellular Penicillin Acylase Institution: Shanghai Institute of Pharmaceutical Industry
Year: 1977 Degree: B.Sc. Subject: Penicillin and Rifamycin Strains Fermentation Process Development Institution: Shenyang Pharceutical University

Work History

Years Employer Title Department
Years: 2014 to 2017 Employer: ADM Company Title: Senior Scientist Department: Research
Amino acids, organic acids and DHA fermentation process development and optimization.
Years Employer Title Department
Years: 1999 to 2013 Employer: Diversa/Verinium Corp. Title: Principal Scientist Department: Pilot Plant
Co-Set up a Pilot Plant with 28 fermenters; Recruiting and training; Designed and developed Delta-V controlled DO Stat and mixed feeding strategies for E.coli, Pseudomonas, Pichia, etc. fermentations; Designed and developed a novel RQ feeding strategy for yeast S.pombe fermentation; Responsible from Master Cell Bank preparation to 190KL commercial-scale production including media and process design and development, optimization, technology transfer, scale-up, and daily commercial production technical support and troubleshooting.
Years Employer Title Department
Years: 1990 to 1999 Employer: IBEX Technologies Inc. Title: Senior Scientist/Group Leader Department: Fermentation
Set up a fermentation Lab with 5 fermenters. Recruiting and training; Designed and developed a pH Stat feeding strategy; E.coli and F.heparinum media and process development, optimization and scale up. cGMP material production for Phase I/II/III clinical trials.

International Experience

Years Country / Region Summary
Years: 1990 to 1999 Country / Region: Canada Summary: Designed and implemented a pH Stat feeding strategy for both wild and recombinant F.heparinum enzymes production; E.coli DCW 60 g/L with enzyme express of 25% of total protein; cGMP material production for Phase I/II/III clinical trials.
Years: 2002 to 2013 Country / Region: Mexico Summary: Technology transfer and scale up from 30 L research to 93/190 KL commercial production. Daily technical support and trouble-shooting.

Career Accomplishments

Associations / Societies
SIM member 1999-2013
Publications and Patents Summary
15 papers and 2 patents.

Language Skills

Language Proficiency
Chinese Mother language

Fields of Expertise

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