Expert Details
Genomic Technologies, Bioinformatics, Computational Biology and their Applications
ID: 727550
Massachusetts, USA
In 1994, Expert moved to the Stanford Human Genome Center at Stanford University, where his work focused on developing new strategies for sequencing regions of human chromosome 21 associated with Down's Syndrome and regions of chromosome 2 associated with Huntington's Disease.
In 1997, Expert was recruited to the faculty at The Institute for Genomic Research (TIGR) in Rockville, MD, where he was a pioneer in the development and application of DNA microarray technologies and the creation of software tools and databases for its analysis. While at TIGR, he established himself as a world leader in genomics and functional genomics and the emerging fields of bioinformatics and computational biology.
In 2005, Expert joined the faculty at the Dana-Farber Cancer Institute and Employer, where his work has focused on genomic profiling using DNA arrays and Next-Generation DNA sequencing technologies to the study of human disease with a focus on women's cancers.
Expert's work has led to more than 150 publication in high-profile peer-reviewed journals, numerous book chapters, tutorials, and editorials. He serves as editor-in-chief for the journal Genomics and on the editorial boards of numerous other scientific journals focused on genomics and bioinformatics. He is in high demand as a speaker and has given a number of prestigious national and international lectures.
Expert and his group have developed many of the laboratory protocols currently enjoying wide use for genomic analysis. The software tools he has created for the analysis of genomic data have been downloaded well over 50,000 times, reaching an estimated >100,000 users worldwide. He has been a leader in the development of standards for data sharing and in the open-source software movement. He has served on numerous grant review panels in the U.S. and Europe and has served on four National Resource Council panels focused on data sharing and applications of genomics.
Expert serves on numerous scientific advisory boards, including the boards of St. Jude's Children's Research Hospital, the Lovelace Respiratory Institute, and the EPA's Board of Scientific Counselors.
A highly experienced, adept teacher and communicator, Expert recently completed a book explaining the sequencing of the human genome and its applications to a broad audience.
Education
| Year | Degree | Subject | Institution |
|---|---|---|---|
| Year: 1990 | Degree: PhD | Subject: Quantum Field Theory and String Theory Models | Institution: UCLA Department of Physics |
| Year: 1984 | Degree: MS | Subject: Theoretical Particle Physics | Institution: UCLA Department of Physics |
| Year: 1983 | Degree: BS | Subject: Physics | Institution: California Institute of Technology |
Work History
| Years | Employer | Title | Department |
|---|---|---|---|
| Years: 2005 to Present | Employer: Undisclosed | Title: Professor of Bioinformatics and Computational Biology | Department: Biostatistics |
Responsibilities:Expert's position involves course development, teaching, and supervising graduate students and postdoctoral fellows in their research. |
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| Years | Employer | Title | Department |
| Years: 2005 to Present | Employer: Undisclosed | Title: Professor | Department: Dept. of Biostatistics and Computational Biology and Dept. of Cancer Biology |
Responsibilities:Expert's work focuses on information integration approaches to the analysis of genomic data and its application to the study of human disease with a focus on women's cancers. His work involves both laboratory and computational approaches and includes the application of DNA microarray technologies and Next-Generation DNA sequencing.He also directs the Center for Cancer Computational Biology, a consulting service that supports genomic data analysis for a large number of academic and commercial organizations. |
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| Years | Employer | Title | Department |
| Years: 1997 to 2005 | Employer: The Institute for Genomic Research | Title: Investigator | Department: Dept. of Mammalian Genomics and Dept of Bioinformatics |
Responsibilities:Expert's work focused on the development of DNA microarray technology, bioinformatics applications to support functional genomics, and their applications to a wide range of questions ranging from drought resistance in human cancer to drought resistance in plants. Expert also worked extensively in the analysis of whole genome sequence data and gene prediction and annotation. |
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| Years | Employer | Title | Department |
| Years: 1994 to 1997 | Employer: Stanford University | Title: Staff Scientist | Department: Stanford Human Genome Center |
Responsibilities:Expert was responsible for developing new approaches to the sequencing of the human genome, with application to human chromosomes 21 and 4; this work included the development of both laboratory protocols and software systems and databases for data analysis. Expert also worked extensively on the development of radiation hybrid maps of the human genome. |
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| Years | Employer | Title | Department |
| Years: 1992 to 1994 | Employer: The Salk Institute | Title: Research Scientist | Department: Molecular Genetics Laboratory |
Responsibilities:Expert was responsible for developing laboratory and computational strategies that led to the physical mapping of human chromosome 11. |
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Additional Experience
| Expert Witness Experience |
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| He has served as an expert witness in three intellectual property cases revolving around intellectual property associated with DNA arrays and DNA sequencing technologies. This involved preparation of expert reports, testifying in Markman hearings, giving depositions, and testifying in trial, all in federal district courts. He also served as an expert in a biotech criminal case that involved the alleged theft of IP by a former employee. |
| Training / Seminars |
|---|
| He has developed and presented countless seminars, workshops, short courses, and full courses throughout his career. He has also given numerous talks to public and civic groups and schools on genomics and its applications. He recently completed a book on genomics and its applications aimed at a mass-market audience that is scheduled for publication in spring of 2010. |
| Vendor Selection |
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| He has done quite a bit of work finding vendors and suppliers for technologies ranging from laboratory instruments, genome sequencing and microarray technologies, and high-performance computing hardware and software. |
| Marketing Experience |
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| He is on the scientific advisory boards of a number of sequencing technology companies and is an expert on genomic technologies for GLG Councils, where he is asked for his opinion on DNA technologies between two and four times each month. |
| Other Relevant Experience |
|---|
| He has been involved in almost every aspect of biotechnology ranging from laboratory technologies to software for data analysis and applications to a wide range of topics including personalized medicine. |
Fields of Expertise
amino acid sequence, analysis, bioinformatics, biological engineering, biotechnology, chromosome, chromosome paint, clinical genetics, DNA, DNA manipulation, DNA sequencing, DNA technology, eukaryotic gene, gene, gene characterization, gene expression, gene fusion, GeneScan, genetic disease, genetic engineering, genetic manipulation, genetic mutation process, genetic sequencing, genetics, genome, genomics, genotype, Genotyper, genotyping, genotyping software, human genome, medical genetics, molecular biology, mutagenesis, nucleotide mapping, pharmacogenomics, plasmid DNA, protein, protein analysis, proteome, proteomics, recombinant DNA, recombinant DNA technology, restriction endonuclease, RNA sequencing, structural bioinformatics, transgenic animal, transgenic technology, computational biology, drug discovery, high-throughput screening (drug discovery), bioethics, recombinant antibody, animal disease model, transgenic organ, fluorescence in situ hybridization probe, dystrophin, Bacillus subtilis, plant genetic engineering, protein characterization, drug validation, peptide microsequencing, protein functionality, protein biochemistry, recombinant cell, drug development, pharmaceutical engineering, computer-aided drug design, protein chemistry, protein engineering, drug, protein sequencing, pharmaceutical chemistry, peptide sequencing, monoclonal antibody, gene therapy, drug screening