Expert Details

Expert in Immunology, Genetics and Immunosuppression, Especially in the Field of Transplantation

Expert ID: 729330 California, USA

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Expert has over 35 years experience in immunology research at Universities and Medical Schools in London, Los Angeles, Oxford and Manchester. The major focus of his research has been in organ transplantation (kidney, heart lung and liver), but has also included autoimmunity, allergy and cancer. Studies were aimed at understanding the immunology of transplant rejection, the regulation of rejection by antibodies and cells of the immune system, and suppressing graft rejection using drugs and biological agents. Initially, research was carried out in animal models. For the last 15 years, the work has been performed entirely in humans, with an emphasis on immuogenetics and pharmacogenetics. The ultimate aim is individualized treatment based on genetic profiling and molecular monitoring of the patient.

As a Professor, Expert has taught medical, dental and biological sciences students in many areas including immunology, genetics, endocrinology, reproduction, neurobiology, cardiovascular and respiratory disease and hematology, and thus has a broad background in medical sciences.

Expert has served on advisory boards for several pharmaceutical companies, and was the expert witness in a major case between two pharmaceutical companies in the High Court in London.

Expert served on the advisory boards of two pharmaceutical companies for the introduction of new immunosuppressive agents.One pharmaceutical company retained Expert to advise on the selection and development of new immunosuppressive agents.A company writing the promotional material for a new immunosuppressive agent used Expert f input and advice. He prepared prose, critical appraisal and a set of slides.

Expert may consult nationally and internationally, and is also local to the following cities: Los Angeles, California - San Diego, California - Long Beach, California - Santa Ana, California - Anaheim, California - Riverside, California - Glendale, California - Huntington Beach, California - San Bernardino, California - Chula Vista, California

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Year Degree Subject Institution
Year: 2001 Degree: DSc Subject: Transplantation Immunology Institution: University of Manchester, United Kingdom
Year: 1976 Degree: PhD Subject: Immunology Institution: University of London, United Kingdom
Year: 1972 Degree: BSc (Hons) Subject: Microbiology Institution: University of Surrey

Work History

Years Employer Title Department Responsibilities
Years: 2005 to Present Employer: Undisclosed Title: Professor of Pharmacy Department: School of Pharmacy Responsibilities: The position requires contributions in research, teaching and administration.
Years: 2006 to Present Employer: Undisclosed Title: S Mark Taper Chair and Director of Research Department: Responsibilities: The director provides leadership and direction in basic and clinical research. The director also plays a role in procuring funding to support the research effort from private donors, foundations, charities, industry and federal sources.
Years: 1987 to 2005 Employer: University of Manchester Title: Professor of Immunology Department: School of Biological Sciences Responsibilities: As the Chair of Immunology, Expert was responsible for teaching in his subject, administration of the department and research. He also supervised many post-graduate research students.
Years: 1981 to 1987 Employer: University of Oxford, United Kingdom Title: Senior Researcher Department: Nuffield Department of Surgery Responsibilities: Expert's role was primarily in research. He also taught immunology to the medical students. He also supervised several post-graduate research students.
Years: 1978 to 1981 Employer: University of London, United Kingdom Title: Research Fellow Department: St Mary's Medical School, Department of Immunology Responsibilities: The responsiblity in the role was entirely research.
Years: 1976 to 1978 Employer: University of California, Los Angeles, USA Title: Post-doctoral Researcher Department: Microbiology and Immunology Responsibilities: Expert's responsibility was to carry out research.

Government Experience

Years Agency Role Description
Years: 1982 to Present Agency: Medical Research Council Role: Reviewer Description: Expert review of grant applications
Years: 1982 to Present Agency: Biotechnology and Biological Sciences Research Council Role: Reviewer Description: Expert review of grant applications
Years: 1990 to Present Agency: National Institutes of Health Role: Invited discussant and reviewer Description: Invited discussant in transplantation and occasional expert reviewer of grants in immunology and genetics.

International Experience

Years Country / Region Summary
Years: to Present Country / Region: United Kingdom Summary: Expert has prepared and delivered educational materials for healthcare professionals and people in the pharmaceutical industry on the mode of action of drugs and drug adverse events. He has also served on advisory boards and in a case of litigation.
Years: to Present Country / Region: Europe Summary: Expert has been involved with European pharmaceutical companies at various levels, and was closely involved in the launch of a new agent in many European countries.
Years: to Present Country / Region: India Summary: Expert participated in a visit to various Indian cities under the title: Beyond Dollie, the future of genetics, sponsored by the British Council. This involved contacts with several Indian pharmaceutical interests.
Years: to Present Country / Region: Japan Summary: Expert was involved with a Japanese pharmaceutical company, travelling to Japan to visit company headquarters, participate in meetings and to meet with company personnel.

Career Accomplishments

Associations / Societies
Expert is a member of The Transplantation Society, the American Transplantation Society, the British Transplantation Society and the British Society for Immunology.
Licenses / Certifications
Expert is HIPPA qualified and certified in Good Clinical Practice.
Professional Appointments
Expert has served on the review boarrds for many societies, charities and journals.

He was the Founding Editor and the Editor-in-Chief of the scientific journal Transplantation Immunology.
Awards / Recognition
The DSc degree held by Expert is the highest academic award that can be bestowed by a British University. Expert was awarded his DSc degree by the University of Manchester in recognition of his lifetime contribution to the field of transplantation and transplant immunology.
Publications and Patents Summary
Expert has published over 250 scientific papers, book chapters and articles. One of his scientific papers has been cited over 1000 times.

Additional Experience

Expert Witness Experience
Expert served as the expert witness for one party in a major patent dispute over an immunosuppressive agent between two large pharmaceutical companies. The case was prepared for the High Court in London, but a settlement was reached just before the hearing.

Expert has served on the advisory boards of several pharmaceutical companies.

Expert has prepared written scientific critiques of new and existing immunosuppressive agents, some of which were used by pharmaceutical companies as promotional materials.
Training / Seminars
Expert has prepared and delivered training courses for doctors, health care professionals and pharmaceutical sales forces. These have been mainly on the mode of action of immunosuppressive drugs. However, one program, delivered many times, was on adverse drug reactions.

Expert spoke on the mode of action of a new immunosuppressive agent at the launch of the drug in various European cities and in Japan.
Marketing Experience
Expert did his PhD in an industrial setting (Wellcome Research Laboratories) and has had many contacts with the pharmaceutical industry, in an advisory and educational capacity, over a long time. He has also had interaction with pharmaceutical companies conducting clinical trials.
Other Relevant Experience
Expert is an experienced and effected communicator, as a lecturer, discussion moderator and scientific writer.

Language Skills

Language Proficiency
English Expert is highly proficient in English.
French Expert's knowledge of French is rudimentary (5 years study at school and 35 years to forget).

Fields of Expertise

allograft, cellular immunity, cellular immunology, cyclosporin, cytotoxic T lymphocyte, genetic probe technology, heart transplant, immune system, immunobiology, immunochemistry, immunogenetics, immunoglobulin, immunology, immunomodulation, immunopharmacology, immunosuppression, immunosuppressive drug, individualized medicine, interferon, interleukin, liver transplantation, lung transplantation, molecular biology, molecular immunogenetics, molecular immunology, organ transplantation, pharmacogenetics, pharmacology, renal transplantation, transplantation, anastomosis, warm ischemia, heterotopic transplantation, cold ischemia, islets of Langerhans transplantation, pancreas transplantation, primary graft dysfunction, immune disorder, adverse drug reaction, experimental treatment, protein drug, tissue and organ harvesting, isotype, epitope, clinical diagnostics, procurement of allograft, allergy, animal disease model, animal study, animal drug testing, animal research, blood sampling, drug clinical trial, immunodiagnostics, molecular genetics testing, human tissue transplantation, molecular medicine, drug resistance, medical research, immunocytochemistry, biological drug level, heart-lung transplant, tissue fixation, genetic probe, humoral immunology, enzyme-linked immunosorbent assay, serology, renal disease, monoclonal antibody, microbiology, medical science, immunotoxicology, immunoassay, hybridoma, heart, genetics, delayed-type hypersensitivity reaction, biomarker, biology, antigen-antibody interaction, antibody

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