Expert Details

Expert in Immunology, Vaccine Research

Expert ID: 108098 Canada

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Expert is an internationally recognized expert in mucosal immunology. He has published more than 70 papers and reviews in several prestigious scientific journals. He is best known for experimentally establishing (with continuing research) the concept of a common mucosal immunologic system in which immunization of the intestine leads to the dissemination of immunity to distant mucosal sites including the gastrointestinal, respiratory and reproductive tracts, the salivary and lactating mammary glands, and the eyes. On the basis of this concept, he has developed an experimental vaccine against genital herpes virus infection and his research team is engaged presently in a large scale project aimed at developing oral and intranasal vaccines for a variety of respiratory viruses and other pathogens.

Expert has considerable expertise in developing and using animal models of infections by bacteria, viruses, and other microbes. He has employed such models to develop vaccine formulations, methods for administration of vaccine materials, monoclonal antibody/immunoassay technologies, and a host of research endeavours in immunology. This area of Expert's expertise is applicable to vaccine and pharmaceutical product development, medical and environmental diagnostic methods, and the biological effects of agricultural and industrial chemicals.


Expert has expertise with the selection and preparation of vaccine materials including whole organisms, viruses, subunit components, and formulation materials. He has identified relevant immunogens from infectious agents using immunochemical methods and is experienced in the preparation of such materials to homogeneity using physical separation processes. These methods are applicable to developing vaccines and biopharmaceutical formulations. In addition, he has expertise in the interpretation of parallel line analyses.


Expert is experienced in preparing, purifying, and characterizing molecular conjugates. This methodology involves the use of homo- and hetero-bifunctional cross-linking reagents and is used to create conjugates of proteins, carbohydrates, peptides, and haptens. He has applied these methods to the development of vaccine materials such as peptide-based immunogens, modified proteins, the development of immunoassays, and receptor-ligand mediated targeted drug delivery. This technology is widely applicable to vaccine and biopharmaceutical development and diagnostic assays.

Arising from his background in pharmaceutical development and drug delivery, Expert has gained expertise in the development of microsphere fabrication technologies. He has filed US and foreign patents in the area of emulsion-based microparticle fabrication for the administration of proteins and other materials via oral, nasal, and systemic routes. This research is relevant to delivery of vaccines, biopharmaceuticals, and drugs.


Expert has studied and evaluated immunologic adjuvants and immunomodulators for inclusion into oral, nasal, and systemic vaccine formulations. He is experienced in the application of conventional adjuvants, recombinant immunomodulators such as cytokines, iscoms, liposomes, microparticles, and antibody-targeted immune complexes. This research has widespread applications in vaccine development.

A significant portion of Expert's career has been devoted to evaluating (in animals) recombinant viral vaccine vectors expressing heterologous gene inserts. This work has focused upon heterologous gene expression in vivo, humoral and cellular immune responses, and vaccine efficacy and safety. Research in this area is relevant to recombinant vaccines and gene therapy using recombinant viruses.


Expert has extensive experience developing monoclonal antibody reagents for research, diagnostic, and therapeutic applications. He has developed more than two dozen reagents of various isotypes, subclasses, and binding affinities having specificities for human, animal, bacterial, viral, and protozoan antigens as well as reagents specific for drugs, drug metabolites, and environmental contaminants such as pesticides and chemical wastes. His work in this area is relevant to the detection and measurement of proteins and carbohydrates, pharmaceuticals/metabolites, agricultural chemicals, chemical wastes and effluents, and to antibody-mediated drug delivery technologies. In addition, he has expertise in the interpretation of parallel line analyses.


Expert has more than 20 years of experience with immunization strategies capable of eliciting immunity at mucosal and systemic anatomic sites. He has used several animal models of infectious diseases to evaluate potential vaccines. Expert is well-known for the discovery of the common mucosal immunologic system. This expertise is relevant to the development of novel vaccines against infections occurring in the gastrointestinal, respiratory and urogenital tracts, and the development of novel vaccination and therapeutic treatments. Expert has served a major, multinational human diagnostics manufacturer as a litigation consultant in the area of immunoassay patent infringement.

Expert has worked extensively in the development of monoclonal and polyclonal antibody-based immunoassays. He has developed liquid- and solid-phase immunoassays using direct, indirect, and competition formats. He has created immunoassays using test tube, microplate, membrane and dipstick technologies. He is familiar with test kits, packaging formats, and cost analyses. Expert has also used these methods to develop immunohistochemical detection methods. His knowledge is especially relevant to detecting and measuring a wide range of molecules applicable to medical diagnosis, drug treatment and metabolites, agricultural chemicals, and chemical wastes and effluents.


Expert has expertise in the development and formatting of enzyme-linked immunosorbent assays, both in liquid or solid phase, for the detection and quantitation of pesticides and agriculturally-important plant viruses. Expert also has similar experience with chromatographic immunoassays. He has served a multi-national chemical producer in the area of herbicide immunoassay. This expertise is readily adaptable and relevant to the rapid and inexpensive detection and quantitation of chemical contaminants in the environment.


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Education

Year Degree Subject Institution
Year: 1979 Degree: PhD Subject: Immunology Institution: McMaster University
Year: 1974 Degree: BSc Subject: Cell Biology Institution: McMaster University

Work History

Years Employer Title Department Responsibilities
Years: 1982 to Present Employer: Undisclosed Title: Professor Department: Department of Pathology Responsibilities:
Years: 1984 to 1987 Employer: Agritech Research, Inc. Title: Director of Research and Development Department: Responsibilities:

Career Accomplishments

Associations / Societies
Expert is a member of the Canadian Society for Immunology, the American Association for Immunologists, and the New York Academy of Science.
Awards / Recognition
He won the Medical Research Council of Canada Studentship as well as Fellowship.

Fields of Expertise

immunobiology, immunology, mucosal tissue, mucosal vaccine, herpes simplex, herpes virus infection, genital herpes, animal disease model, animal vaccine, biological virus production, polyclonal antiserum, vaccine, veterinary immunology, vaccination, bacterial vaccine, parallel line analysis, immunotoxin, hapten, drug-delivery microsphere, microsphere coating process, microsphere, immunologic adjuvant, immunomodulation agent, recombinant antibody, vaccine vector, humoral immunology, antigen, monoclonal antibody, monoclonal antibody production, antiserum, blood serum, antibody, antibody production, antigen-antibody interaction, immune serum, immunochemistry, immunoassay, immunohistochemistry, microplate, polyclonal antibody, environmental immunochemical assay, environmental impact assessment, enzyme-linked immunosorbent assay, assay development, enzyme immunoassay, vaccine research, recombinant, genitalia, assay protocol, biopharmaceutical product development, environmental economic analysis, isotype, epitope, carbohydrate antigen, non-specific binding, iodine-125, microtiter plate, immunoglobulin G, bronchiolitis, respiratory syncytial virus, viral assay, dry reagent, bacterial toxin, pharmaceutical product development, clinical instrumentation, environmental safety, particle-based immunoassay, colloidal particle coating process, immunosuppression, hemolysis, agglutination, radiolabeled chemical, opsonin, fluorescein, polymer drug-delivery microsphere, ligand, allergic contact dermatitis, antigen synthesis, molecular medicine, immunofluorescence, environmental analytical chemistry, medical research, biological response modifier, baculovirus expression vector system, immunocytochemistry, clinical flow cytometry, immunity, disease, common cold virus, drug delivery, histology, food allergy, controlled-release drug delivery, enterobacterium, cellular immunology, herpesvirus, cytokine, protein, virology, toxin, tissue (histological), suspension polymerization, serology, radioactive labeling, magnetic microsphere, influenza, infectious disease, hybridoma, enterovirus, delayed-type hypersensitivity reaction, Chlamydia bacterium, chickenpox, biology, bacterium, bacillus Calmette-Guerin vaccine

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