Expert Details

Expert in Infectious Disease Diagnostics and Scientific Leadership

Expert ID: 736094 California, USA

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I am a computer scientist who built and led bioinformatics teams at Lawrence Livermore National Laboratory (LLNL) from 1978-2018. This included the Human Genome Program (1987-2000) and a pathogen bioinformatics team (2000-2018). My team designed PCR assays, microarrays, and sequencing solutions for government agencies and industry. I now provide independent technical and management consulting and managerial coaching to biotech startups (Point of Care PCR, CRISPR, arrays, microbiome analysis, etc.) from inception through Series A funding.

Expert may consult nationally and internationally, and is also local to the following cities: San Francisco, CA - San Jose, CA - Oakland, CA

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Education

Year Degree Subject Institution
Year: 1977 Degree: MS Subject: Computer Science Institution: UC Davis
Year: 1975 Degree: BS Subject: Computer Science Institution: University of San Francisco

Work History

Years Employer Title Department Responsibilities
Years: 2018 to Present Employer: Undisclosed Title: CEO and co-founder Department: Responsibilities: Provide technical and managerial consulting/coaching to biotech startups from inception through Series A funding rounds. Other roles include director, advisor, and scientific advisor. Current and recent clients have been in CRISPR, Point of Care PCR, single-cell sequencing, microarray, microbiome, and novel diagnostic modality spaces.
Years: 1978 to 2018 Employer: Lawrence Livermore National Laboratory Title: Associate Program Leader, Bioinformatics Department: Global Security Responsibilities: I built and led multi-disciplinary scientific teams on the Human Genome Project (1987-2000) and pathogen biodefense projects sponsored by Homeland Security, Defense Department, and Intelligence agencies (2000-2018.) I served on 5 National Academy of Science committees focused on biodefense topics from 2009-2018. My team developed pathogen diagnostic solutions that were used in nationwide biodefense programs as well as by researchers world-wide on a range of human and animal health issues.

Computer scientist supporting biological and biodefense research
• Awarded 7 patents on pathogen detection and 1 patent on database technology
• Built and led bioinformatics for LLNL Human Genome Center (1987-2000). Developed key algorithms for physical mapping and built database infrastructure for mapping and sequencing Human Chromosome 19. Co-author on 2001 Nature publication of the first human genome.
• Principle Investigator on the following multi-year projects:
o Microbial Forensic Encyclopedia, DHS (2008-2014)
o Transformational Medical Technology, DTRA (2009-2012)
o Bioinformatics Research, Intelligence Community (2003-2011)
o Novel Immuno Signatures, DHS (2011-2014)
o Microbial Forensics, DoD (2012-2015)
o Next-Gen Sequencing as a Diagnostic, DTRA (2012-2014)
o Bio-Intelligence Chip Test & Evaluation, IARPA, (2015-16)
o Genes of Concern, DHS (2015-2018)
o Microbial Forensics, DoD (2016-2018)
o Functional and Computational Analysis of Threats, IARPA (2016-2018)
o BioWatch Data Management System Expansion, DHS (2017-2018)
• Built and led Pathogen Bioinformatics team (2000-2018) that co-developed the nationwide BioWatch system (in 24x7 mode since 2003 in 30+ US cities, monitoring for aerosol bioterror pathogen releases.)
• Led the LLNL team that designed and eventually commercialized a pan-microbial microarray that detects > 14,000 bacteria, viruses, and fungi. This required enormous database infrastructure and supercomputers.
• Co-Chaired CDC Blue Ribbon Panel on Bioinformatics (2011) that led to Congress providing ~$40M/yr new funding in 2013 for the Advanced Molecular Detection program that provided DNA sequencing technology to Public Health labs in all 50 states.
• Invited member of CDC Multipathogen Platform Consultation for Respiratory Diseases, 2018
• Chaired the Advisory Boards of the USDA/NSF/DOE-funded US Rice Genome Sequencing and Annotation programs (2000-2008) and the Maize Database grant (2002-2007).
• Member, Jackson Lab Mouse Genome Database advisory board (1997-1999)
• Served on 4 National Academy of Science panels on biodefense topics (Select Agent science, DoD laboratory competency, PCR Standards for BioWatch, Synthetic Biology Risk) from 2009-2018.
• Appointed to the National Academy of Science Standing Committee advising the DoD’s Senior-level manager of Programs to Counter Biological Threats (2012-2015)
• Chaired NIAID Genome Sequencing Centers (2008) and Infectious Disease Centers (2013) proposal reviews that each led to $40M+ funding for multiple 5-year contracts
• Invited Speaker, FDA Public Meeting: “Advancing Regulatory Science for High Throughput Sequencing Devices for Microbial Identification and Detection of Antimicrobial Resistance Markers”
• Invited Speaker, FDA Public Meeting on Validating Highly-Multiplexed Assays, 2011
• National Biosurveillance Advisory Subcommittee member, 2010-2013
• First Computer Scientist named as a Distinguished Member of the Technical Staff at LLNL (2012)
• Informatics consultant, Radiation Effects Research Foundation, Hiroshima Japan, since 1998

Government Experience

Years Agency Role Description
Years: 2011 to 2011 Agency: Centers for Disease Control (CDC) Role: Special Government Employee Description: I co-chaired the CDC's Blue Ribbon Panel on Bioinformatics that led to Congress funding the Advanced Molecular Detection program since 2013.

International Experience

Years Country / Region Summary
Years: 1986 to 1986 Country / Region: China Summary: Co-taught computer science at Peking University in a program run by the Ministry of Science and Technology.

Career Accomplishments

Professional Appointments
• Principle Investigator on the following multi-year projects:
o Microbial Forensic Encyclopedia, DHS (2008-2014)
o Transformational Medical Technology, DTRA (2009-2012)
o Bioinformatics Research, Intelligence Community (2003-2011)
o Novel Immuno Signatures, DHS (2011-2014)
o Microbial Forensics, DoD (2012-2015)
o Next-Gen Sequencing as a Diagnostic, DTRA (2012-2014)
o Bio-Intelligence Chip Test & Evaluation, IARPA, (2015-16)
o Genes of Concern, DHS (2015-2018)
o Microbial Forensics, DoD (2016-2018)
o Functional and Computational Analysis of Threats, IARPA (2016-2018)
o BioWatch Data Management System Expansion, DHS (2017-2018)
• Co-Chaired CDC Blue Ribbon Panel on Bioinformatics (2011) that led to Congress providing ~$40M/yr new funding in 2013 for the Advanced Molecular Detection program that provided DNA sequencing technology to Public Health labs in all 50 states.
• Invited member of CDC Multipathogen Platform Consultation for Respiratory Diseases, 2018
• Chaired the Advisory Boards of the USDA/NSF/DOE-funded US Rice Genome Sequencing and Annotation programs (2000-2008) and the Maize Database grant (2002-2007).
• Member, Jackson Lab Mouse Genome Database advisory board (1997-1999)
• Served on 4 National Academy of Science panels on biodefense topics (Select Agent science, DoD laboratory competency, PCR Standards for BioWatch, Synthetic Biology Risk) from 2009-2018.
• Appointed to the National Academy of Science Standing Committee advising the DoD’s Senior-level manager of Programs to Counter Biological Threats (2012-2015)
• Chaired NIAID Genome Sequencing Centers (2008) and Infectious Disease Centers (2013) proposal reviews that each led to $40M+ funding for multiple 5-year contracts
• Invited Speaker, FDA Public Meeting: “Advancing Regulatory Science for High Throughput Sequencing Devices for Microbial Identification and Detection of Antimicrobial Resistance Markers”, 2014
• Invited Speaker, FDA Public Meeting on Validating Highly-Multiplexed Assays, 2011
• National Biosurveillance Advisory Subcommittee member, 2010-2013
Awards / Recognition
• Recipient of two R&D 100 Awards, (BioWatchand Applied Biosystems Axiom Microbiome Array)
• First Computer Scientist named as a Distinguished Member of the Technical Staff at Lawrence Livermore National Laboratory
Publications and Patents Summary
Expert has co-authored over 40 peer-reviewed publications and book chapters in the fields of bioinformatics, pathogen detection and characterization, microbial forensics, and related topics. He has 6 issued US patents on PCR detection of various infectious microbes and one issued US patent on data warehouse technology.

Additional Experience

Training / Seminars
Expert has taught Unix, C programming, Perl Programming, and Bioinformatics Infrastructure courses for UC Berkeley Extension (1988-1991, 1999-2001). He co-taught MS-level computer science classes at Peking University (Fall, 1986) and UC Davis LLNL campus, 1982-1984.
Vendor Selection
Expert has participated or led vendor selection activities throughout his LLNL career (1978-2018.) These focused on computer hardware and software purchases.
Other Relevant Experience
Expert was one of 4 people asked by the CDC in May 2020 to review their data on a new COVID-19 PCR assay, prior to submission to the FDA for Emergency Use Authorization.

Fields of Expertise

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