Expert Details

Expert in Medicinal Chemistry, Synthetic Organic Chemistry, Drug Discovery, Pharmacokinetics

Expert ID: 730214 Wisconsin, USA

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Expert has strong knowledge in asymmetric multi-step organic synthesis, scaffold design and library development with ability to solve challenging chemistry problems and have authored peer-reviewed articles and patents. Expert is a synthetic and medicinal chemist with over 13 years of experience in complex natural product synthesis, small molecule synthesis, asymmetric catalysis, organoborane chemistry, SAR study and synthetic methodology. Expert demonstrated the ability to work within multidisciplinary team of experts in industrial setting to drive hit-to-lead projects and to generate novel synthetic analogs for biological studies.

Expert is assiduous researcher. His knowledge of organic synthesis (both conceptual and empirical) is exemplary and is well represented through his research work. His acumen to organic synthesis is well represented through his research on stereoselective synthesis of optically active alpha-amino acids which was successfully accomplished.

Expert is creative and motivated researcher. His cutting edge approach, optimism and perseverance have been the cornerstone of success. We had several beneficial interactions on our research projects. His amiable nature makes him a very pleasing coworker.

He has accumulated sound knowledge and experience in various areas of organic chemistry such as total synthesis, medicinal chemistry, asymmetric synthesis/catalysis, pharmacokinetics, and organoborane chemistry.”

Expert may consult nationally and internationally, and is also local to the following cities: Milwaukee, Wisconsin - Madison, Wisconsin - Green Bay, Wisconsin - Kenosha, Wisconsin - Racine, Wisconsin - Appleton, Wisconsin - Waukesha, Wisconsin - Oshkosh, Wisconsin - Janesville, Wisconsin - Waukegan, Illinois

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Education

Year Degree Subject Institution
Year: 2004 Degree: PhD Subject: Organic Chemistry Institution: Indian Institute of Chemical Technology
Year: 1997 Degree: MS Subject: Chemistry Institution: Kakatiya University
Year: 1995 Degree: BS Subject: Chemistry, Botany, Zoology Institution: Kakatiya University

Work History

Years Employer Title Department Responsibilities
Years: 2011 to Present Employer: Undisclosed Title: Acting Instructor of Chemistry Department: Department of Chemistry Responsibilities:
Years: 2007 to 2010 Employer: University of Washington Title: Research Associate Department: Department of Chemistry Responsibilities:
Years: 2004 to 2006 Employer: Purdue University Title: Research Associate Department: Department of Chemistry Responsibilities:

International Experience

Years Country / Region Summary
Years: 2004 to 2006 Country / Region: United States Summary: Expert worked as a research associate at the department of chemistry in Purdue University.
Years: 2007 to 2011 Country / Region: United States Summary: Expert worked as a research associate at the department of chemistry in University of Washington.

Career Accomplishments

Associations / Societies
American Chemical Society;
American Chemical Society-Fluorine Division;
Drug Discovery News;
The Pacific Northwest Mass Spectrometry Group
Awards / Recognition
• Awarded a highly competitive research fellowship (Junior Research Fellowship) after qualifying National Eligibility Test (NET) conducted by Council of Scientific and Industrial Research (CSIR), Government of India. Qualified for lectureship in colleges and universities.

• Qualified Council of Scientific and Industrial Research (CSIR), Senior Research Fellowship.

• Dr. K. V. Rao Scientific Society for Promotion of Science, India; Young Scientist Research Award-2003.

• Best Performance/Publication Award (2002) by Indian Institute of Chemical Technology (IICT) on Council of Scientific and Industrial Research (CSIR) foundation day for the paper in Angew. Chem. Int. Ed. (2001).

• Best Performance/Publication Award (2003) by Indian Institute of Chemical Technology (IICT) on Council of Scientific and Industrial Research (CSIR) foundation day for the paper in J. Am. Chem. Soc. (2002).
Publications and Patents Summary
Expert published several papers in peer-reviewed international journals including Journal of the American Chemical Society, Angew. Chem, Journal of organic Chemistry. etc. and filed 24 international patents (US, World, UK, European, Japan. etc.).

Additional Experience

Expert Witness Experience
Expert is experienced in handling air-sensitive reagents/reactions, separation of compounds by flash column chromatography, structure elucidation of organic/organometallic compounds by UV, IR, NMR & Mass spectroscopy.

Expert performed key synthetic reactions like Brown’s allylation and crotylation, Suzuki-Miyaura, Negishi coupling, Sharpless dihydroxylation, Heck-, Stille- and Sonogashira coupling reactions.

Expert synthesized alkyllithium/alkylmagnesium, organo-zinc, organo-copper and organo-boron reagents.

Expert is conversant with modern separation techniques (GC and HPLC), search databases (Scifinder, Beilstein etc.). Instruments operated: GC, HPLC, NMR, IR, UV, polarimeter, Mass, LC-MS/MS etc.
Training / Seminars
Expert trained graduate and undergraduate students both in conceptual and experimental organic chemistry.
Marketing Experience
Expert developed and synthesized milligram to multigram quantities of several complex intermediates of the typical calcium antagonist “(+)-Diltiazem” via transition metal catalyzed multistep stereoselective organic transformations, and the technology has been transferred to SMS pharmaceuticals Ltd, INDIA

Expert also developed short and practical method for the synthesis of Taxol side chain, which is proved to be essential for the biological activity of Taxol, and the technology was transferred to SMS pharmaceuticals Ltd, INDIA

Language Skills

Language Proficiency
HINDI
TELUGU

Fields of Expertise

boron chemistry, chiral chromatography, drug blood level determination, drug discovery, organic synthesis, pharmacokinetics, enantioselective heterogeneous catalysis, organoborane, analytical method optimization, active pharmaceutical ingredient, high-throughput screening (drug discovery), chiral synthesis, chiral separation, phase-transfer catalysis, synthetic crude, heterocyclic compound synthesis, aromatic compound synthesis, amino acid methyl ester, amino acid ester, rational drug design, boron analysis, aromatic diamine, pharmaceutical research and development, enzyme inhibitor, sodium fluoroborate, boron trichloride, aromatic ester, prodrug, peptide coupling, organic compound manufacturing, drug metabolite, pharmaceutical product development, boron hydride chemistry, hydride chemistry, boron trifluoride, supported palladium catalyst, supported metal catalyst, catalyst poison, medicinal chemistry, chiral high-performance liquid chromatography, fine organic synthesis, catalyst regeneration, homogeneous transition metal catalysis, heterogeneous transition metal catalysis, transition metal catalysis, transition metal catalyst, enantioselective catalysis, aromatic compound nitration, aromatic compound catalytic hydrogenation, chirality, pharmaceutical design, enzyme activity assay, transition-metal-mediated organic reaction, asymmetric synthesis, palladium recovery, catalyst recycling, drug development, palladium compound, catalyst mechanism, aromatic isocyanate, chemical process inhibitor, palladium homogeneous catalysis, palladium catalysis, palladium catalyst, heterocyclic chemistry, organopalladium chemistry, synthesis, chemical reaction, alkylation, inorganic catalysis reagent, boron compound, enzyme mechanism, synthesis chemistry, Friedel-Crafts reaction, molecular chirality, chemical reaction mechanism, chemical synthesis, aromatic compound, chemical compound, surface chemistry, quantitative structure-activity relationship, pharmaceutical chemistry, organometallic compound, organometallic chemistry, organic chemistry, inorganic synthesis, inorganic chemistry, homogeneous catalysis, heterogeneous catalysis, chemistry, catalytic hydrogenation, catalyst, catalysis reagent, catalysis, bulk pharmaceutical chemical manufacturing, boric acid, asymmetric induction, aromatic hydrocarbon, aromatic amine, aromatic aldehyde, aromatic alcohol, aromatic acid

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