Expert Details

Expert in Microbial Fermentation, Industrial Microbiology, Biotechnology

Expert ID: 728517 New Jersey, USA

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Expert. Expert has led fermentation and strain improvement efforts for a variety of anti-bacterial, anti-fungal, statins, ion-channel inhibitors, and immunoregulant natural products produced by actinomycetes and filamentous fungi. Expert led development of the Glarea lozoyensis fermentation process for producing Cancidas®, first in class systemic anti-fungal.

Expert has established a robust, high-throughput (1000-2000) microbial screening platform using 24 deep well plates, commercially available liquid handing equipment (TECAN), bioassays where applicable, and high-throughput HPLC.

Expert. Expert has produced therapeutic and drug target proteins using E. coli, S. cerevisiae, transient transfection, hybridoma cultivation, and Pichia pastoris expression systems. Expert established and led small scale protein production team charged with providing 10s-100s mg of pre-clinical therapeutic proteins for evaluation (biophysical, PK/PD, efficacy). ˜350 proteins delivered during 18 month time frame. Established outsourcing partnerships for non-core activities.

Expert. Expert has worked on whole-cell biocatalysis processes for producing chiral intermediates, particularly keto-reductions. Expert developed (and patented) a Pseudomonas putida dioxygenase bioconversion process converting indene to the corresponding chiral diol, an intermediate in Crixivan®

Expert. Expert is working with a start-up company to produce a sustainable biochemical by fermentation of a highly engineered E. coli strain.

Expert. Expert is working with a division of a large pharma company to produce antigens by heterologous expression in yeast.

Expert. Expert served as a fermentation expert witness in a Canadian litigation case. This inlcuded drafting an expert statement, responding to the expert statement of opposing counsel's expert witness, and examination and cross-examination in court.Expert. Expert is working with a CRO to expand their small scale protein production capability.

Expert may consult nationally and internationally, and is also local to the following cities: New York, New York - Yonkers, New York - Newark, New Jersey - Jersey City, New Jersey - Paterson, New Jersey - Elizabeth, New Jersey - Bridgeport, Connecticut - New Haven, Connecticut - Stamford, Connecticut - Philadelphia, Pennsylvania

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Education

Year Degree Subject Institution
Year: 1991 Degree: Ph.D. Subject: Microbiology Institution: Ohio State
Year: 1984 Degree: BS Subject: Biology, Chemistry Institution: Norwich University

Work History

Years Employer Title Department Responsibilities
Years: 2009 to Present Employer: Undisclosed Title: Owner/Presient Department: Responsibilities: Expert. Expert provides scientific consulting for the fermentation, industrial microbiology, biofuels, and biotechnology sectors.
Years: 1991 to 2008 Employer: Merck & Co. Title: Senior Investigator Department: Bioprocess R&D Responsibilities: Expert. Expert has experience with a diverse bioprocess development portfolio: fermentation and strain improvement for producing bioactive natural products (e.g., Cancidas®), therapeutic protein and monoclonal antibody production by cell culture and P. pastoris expression systems, whole-cell biocatalysis for the production of chiral intermediates, fermentation of pathogenic bacteria for polysaccharide vaccine development.

Career Accomplishments

Associations / Societies
Society for Industrial Microbiology
Professional Appointments
In May 2010 Expert. Expert was voted president-elect of the Society for Industrial Microbiology and served as a director for SIM from 2006-2009. He also serves on the editorial boards of two peer-reviewed journals: Journal of Industrial Microbiology and Biotechnology (Springer) and Enzyme and Microbial technology (Elsevier).

Publications and Patents Summary
Expert. Expert is a contributing author on numerous peer reviewed papers, book chapters, patents, and published abstracts. Expert is also a sought after seminar speaker at conferences and universities.

Additional Experience

Expert Witness Experience
Expert. Expert was retained as a microbial fermentation expert witness in a Canadian litigation case. He wrote an expert statement, responded to the opposing counsel's expert witness' assertions, and underwent examination and cross-examination in court.
Vendor Selection
While at Merck, Expert. Expert identified vendors to produce bulk plasmid for transient transfection, custom gene synthesis, and reagent protein production.

Fields of Expertise

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