Expert Details

Expert in Microbiology, Biotechnology, Cleanroom Microbiology, Sterilization, etc.

Expert ID: 722161 Connecticut, USA

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As a consultant, Expert has used his broad-based scientific background to work with a variety of clients. These clients have required expertise in such widely divergent subjects as the production of cellulosic ethanol (requiring a knowledge of basic thermodynamics, enzyme biochemistry, and understanding of fermentation and distillation) and detection of biowarfare weapons (requiring a knowledge of sensor technology and microbiology).

Expert’s academic research career was spent in the general area of molecular biochemistry. A large portion of this research was spent more specifically in the area of structural biochemistry. He has had an extensive research career in biochemical research and has focused on research in the areas of structural biology (emphasis on nuclear magnetic resonance [NMR] spectroscopy), immunochemistry, protein chemistry, and neuropharmacology. Expert is the senior author of over 120 original research publications in this area.

Expert is familiar with a wide range of bioinstrumentation, including PCR thermal cyclers, optical and fluorescence spectroscopy, infrared spectroscopy, nuclear magnetic resonance (NMR) spectroscopy, electroporation, and most other instrumentation found commonly in molecular biology laboratories. He has extensive experience with a wide variety of biomedical instruments and mainframe and desktop computing.

Expert has taught biophysical chemistry at the graduate and undergraduate levels and is a co-editor and author (along with M.D. Deutscher) for a popular recent textbook on biophysical chemistry entitled "Introduction to Biophysical Methods in Protein and Nucleic Acid Research", [Academic Press, 1995]. Many of Expert's research papers concern areas in biophysical chemistry.

Expert's research career has encompassed many areas of protein biochemistry as well, including the structural chemistry, purification, analysis, and sequencing of proteins. He has taught protein biochemistry at the graduate level.

Expert's laboratory was one of the first to report the production, and to examine the properties, of anti-drug monoclonal antibodies. His laboratory also used these antibodies for the later production, and to examine the properties of, polyclonal anti-idiotypic antibodies that mimic the binding of the original drugs at their cellular receptors. Their immunochemical properties were investigated using physical, biochemical and molecular biological techniques. Expert is senior author on many original research publications describing and reviewing these findings.

Expert has extensive teaching experience in biochemistry at the technician, undergraduate, graduate and medical/dental undergraduate student levels. He is able to effectively bring home the general concepts of biochemistry at any of these levels.

Expert's research in recent years kept focus on the biochemistry of G-protein coupled receptors (GPCRs). In particular, his laboratory has been concerned with the cellular biological aspects of the receptors for narcotic analgesics. The laboratory reports stemming from this work concerned the signal transduction pathways activated by receptor activation.

Expert's company has examined the magnetic resonance imaging (MRI) compatibility of medical devices for a major manufacturer. Expert arranged the delivery of a rental MRI to the manufacturer's site, designed and wrote the testing protocol, performed the testing, and analyzed the results. With his generalized knowledge of instruments and test procedures, he is able to aid in product development for a wide variety of devices.

Expert has been a member and taught in a graduate program in neuroscience for 20 years. His research in this area has concentrated on neuropharmacology and molecular biology of peptides and narcotic analgesic drugs.

Expert's recent research has been on the neuropharmacology of narcotic analgesic drugs. He has taught aspects of neuropharmacology, particularly neuropeptides, at the graduate student level. He is currently under contract to write an extensive review of pharmacogenomics/pharmacogenetics for a major publisher of drug research reports.

As a consultant in the broad area of biotechnology, Expert has furnished clients with:
(1) written technology assessments of new advances
(2) written articles on the scientific basis of future developments
(3) taken part in research focused on developing methods

Expert has used electroporation of bacterial cells as a research tool. He has also developed applications of electroporation to transforming mammalian cells.

As a consultant, for 7 years, Expert has been giving a course on cleanroom microbiology and the problem of minimizing the entry of environmental microbials into the working environment. He has also been a scientific advisor for companies manufacturing products for removal of microbials from the home and industrial environments.

As an academic researcher, Expert's group was one of the first to develop monoclonal antibodies to opiate drugs and to opiate peptides. They developed new techniques to monitor hybridomas expressing the desired monoclonal antibodies.

Expert has taken part in seminars, and consulted for companies in the field of microbials that can be used to remove industrial wastes such as oils and greases from factories and homes.

Expert spent a large part of his academic research career studying the structures of macromolecules using nuclear magnetic resonance spectroscopy as a tool. He is co-editor of a textbook on macromolecular physical chemistry.

Besides using microbiology tools in his academic research, Expert headed a teaching committee charged with instructing medical students on basic microbiology. As a consultant he has lectured on microbiology in cleanrooms for 7 years.

Expert's PhD is in the field of chemical physics (then a branch of physical chemistry). He has given courses in physical chemistry, at the post-graduate level.

As part of his research on macromolecular physical chemistry, Expert also worked with the structures of many polymers.

Expert has published several papers on protein biochemistry, in particular focused on the protein biochemistry of narcotic receptors.

Expert did pioneering nuclear magnetic resonance research on bulk liquid water, and the interactions of water with surfaces. A large number of publications in his early research career are on this subject.

Expert has consulted with a major company on the compatibility of their brain catheters with magnetic resonance imaging devices.For a client, he has written a proposal to the Department of Energy for $30M to support the client's new technology for producing cellulosic ethanol.For a client, he has presented public and private courses in cleanroom and sterilization technologies for the last 7 years.He has written articles for a new biomedical website being developed for clinical physicians.On a consulting contract a Company, he took a position as acting Research Director for the Company's new Division of Biotechnology. He interviewed and hired professional and technical staff for the Division, and directed their research for 2 1/2 years.

Expert may consult nationally and internationally, and is also local to the following cities: New York, New York - Yonkers, New York - Boston, Massachusetts - Worcester, Massachusetts - Springfield, Massachusetts - Newark, New Jersey - Jersey City, New Jersey - Paterson, New Jersey - Bridgeport, Connecticut - Providence, Rhode Island

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Education

Year Degree Subject Institution
Year: 1959 Degree: Ph.D. Subject: Chemical Physics Institution: University of Chicago
Year: 1955 Degree: B.S. Subject: Chemistry Institution: California Institute of Technology

Work History

Years Employer Title Department Responsibilities
Years: 2001 to Present Employer: Undisclosed Title: Managing Member Department: Responsibilities: He is a scientific consultant
Years: 1970 to 2001 Employer: University of Connecticut Health Center Title: Professor of Biochemistry Department: Dept. of Microbial, Molecular, and Structural Biology Responsibilities: He was a basic science researcher and educator.
Years: 1964 to 1969 Employer: Columbia University School of Medicine Title: Assistant Professor Department: Dept. of Biochemistry Responsibilities: He was a basic science researcher and educator.
Years: 1962 to 1964 Employer: United States Air Force Title: Capt. Department: 1155 Technical Operations Squadron Responsibilities: He was a nuclear research officer.

Government Experience

Years Agency Role Description
Years: 1970 to 2001 Agency: National Institutes of Health, National Science Foundation Role: Grant Proposal Reviewer Description: Expert was a member of various ad hoc grant proposal review committees during this period.
Years: 1962 to 1964 Agency: United States Air Force Role: Nuclear Research Officer Description: He did classified work on nuclear weapons testing.

International Experience

Years Country / Region Summary
Years: to Present Country / Region: Hungary Summary: Expert was a National Academy of Sciences Exchange Visitor, Biochemistry Research Institute, Szeged, Hungary, 1990.
Years: to Present Country / Region: Australia Summary: He was a Visiting Fellow, Research School of Chemistry, Australian National University, Canberra, Australia, 1988.
Years: to Present Country / Region: Germany Summary: He was a Visiting Senior Scientist, Institut für Physikalische Chemie, Rheinisch-Westfällischen Technischen Hochschule, Aachen, W. Germany, 1985.
Years: to Present Country / Region: India Summary: He was a National Science Foundation Exchange Lecturer, Molecular Biophysics Institute, Indian Institute of Science, Bangalore, India, 1974.
Years: to Present Country / Region: Yugoslavia Summary: He was National Academy of Sciences Exchange Lecturer, Department of Biology, University of Zagreb, Zagreb, Yugoslavia, 1967.

Career Accomplishments

Associations / Societies
Expert is a member of the American Chemical Society, the American Society for Biochemistry and Molecular Biology, the PDA, the IEST, the ISPE, and the AOAC.
Professional Appointments
He is Professor Emeritus of Biochemistry, Univ. of Connecticut Health Center. He was a Fogarty Senior International Fellow, Department of Biochemistry, Imperial College of Science and Technology, London, England, 1979-1980.
Medical / Professional
He had National Science Foundation post-doctoral fellowships from 1960 to 1962.
Publications and Patents Summary
Expert has 120 original research publications and has edited and contributed to a textbook on biophysical chemistry.

Additional Experience

Training / Seminars
As a consultant Expert has taught courses in cleanroom microbiology and sterilization techniques to a large number of classes over the past 7 years. As an academic educator, Expert has developed and taught in courses at the undergraduate and graduate level in chemistry, biochemistry and biophysical chemistry. Additionally, Expert lectured on various scientific topics to groups in Asia and Europe.

He has participated in the development of curricula in the basic biomedical sciences for medical and dental students and has taught in these curricula. He has acted as a facilitator in problem-based learning curricula for first- and second-year medical students. He has also organized and presented seminars in the sciences throughout his career.
Vendor Selection
Expert has wide experience with vendors in all areas of scientific instrumentation and biomedical suppliers. He has negotiated contracts in these areas throughout his career.
Marketing Experience
Expert has written advanced technology assessments for companies in a variety of scientific/technical areas including: industrial cleaning techniques, sterilization technologies, infrared drying technologies, and ionic effect technologies. He has closely followed trends in industrial cleanup methods, microbial decontamination technologies, and home cleaning technologies.
Other Relevant Experience
He has wide experience in many areas of experimental and theoretical sciences. And he has extensive experience in the use of many software programs for desktop computers including scientific programs, desktop publishing, Web-based publishing, word processors, and graphics programs.

Fields of Expertise

biochemical research, biochemistry, molecular biochemistry, bioinstrumentation, biomedical instrument, biomedical instrumentation, biophysical chemistry, physical biochemistry, protein biochemistry, immunochemistry, monoclonal antibody, qualitative biochemistry, receptor biochemistry, medical device product development, medical device reporting, medical device safety, medical device testing, neuroscience, neuropharmacology, biotechnology, electroporation, environmental microbiology, hybridoma technology, industrial microbiology, macromolecule physical chemistry, microbiology, physical chemistry, polymer physical chemistry, radiolabeled monoclonal antibody, water physical chemistry, clean room microbiology, biomedical physics, nuclear weapon safety, nuclear safety, proteomics, genomics, proteome, industrial biotechnology, physical organic chemistry, medicinal chemistry, microbial biochemistry, microbiological physiology, bioenergetics, medical microbiology, bioorganic chemistry, protein biology, molecular pharmacology, immunogenetics, molecular biochemistry, microbial genetics, immunobiology, genome, DNA technology, analytical biochemistry, free radical biochemistry, immunocytochemistry, clinical microbiology, high-pressure sterilization, molecular genetics, neurochemistry, chemical kinetics, enzyme technology, gene, thermochemistry, stereochemistry, protein sequencing, pharmacology, molecular biophysics, molecular biology, metabolism, gene expression, enzymology, electrochemistry, biomedical diagnostic instrumentation, chemical analysis, cell anatomy, catalysis, biophysics, biochemistry, bacteriology, applied microbiology

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