Expert in Molecular Psychiatry and Neuroscience, Neuropharmacology, Cancer Immunotherapy
Expert ID: 731256 United Kingdom
At the moment, some novel and exciting unpublished strategies for treatment of ADHD are considered by Expert. He obtained in vitro data supporting the idea that such treatment with naturally existing molecules will result in better development of children’s brain and possibly take care for removing the insomnia from which ADHD patients suffer. Expert is particularly interested in pursuing this new treatment strategy in animal models and in patients.
He has also consulted on applicability of different nanoparticles carriers of drugs in neorodevelopmental and other neurological disorders. This is a very important issue because in general all drugs and their carriers are tested for toxicity while not taking good care for their potential adverse effects by a complex assessment of physiological alterations that might occur.
He has combined his extensive expertise in molecular biology, immunology, molecular neuroscience and cancer biology to develop a new avenue in the discovery of suitable molecular targets for treatment of different tumour types which result specifically in killing the cancer cells while not having significant effect on non-malignant ones. These strategies have been tested both in vitro and in vivo showing a great promise. Some of the designed peptides have been filed for a patent application.
Highly creative science leader with over 20 year experience in life and pharmaceutical sciences with particular emphasis on protein chemistry, immunotherapeutics, neuroscience/molecular psychiatry, working for organisations in Europe, North America and Middle East, focused on innovation and development of new therapeutics.
Outstanding manager with unique profile, combining strong technical and teaching/training expertise, innovatively leading multi-cultural teams to deliver growth solutions.
A proven track record in discovery of new therapeutic targets and development of new treatments.
Influencing and growing life science publishing business and implementing a consumer-focused approach.
CORE QUALIFICATIONS & STRENGTHS
Effective and innovative project and people management
Strategic agility, project planning and budgeting
Product development: discovery of new therapeutic targets and drug development
Led and successfully completed a number of projects focused on:
Design and assessment of oral formulations of therapeutic antibodies for treatment of infections and disorders of the gastrointestinal tract
Signalling/molecular mechanisms underlying inflammatory responses in neuropsychiatric disorders and identification of suitable therapeutic targets for drug development
Design of peptide adjuvants for targeted sensitisation of certain tumours to immunoclearance
Currently organizing clinical trial
Consulted on interrelationship between complement system and clock genes in ADHD as a strategy for treatment of ADHD patients.He consulted on biomarkers for the response to drug treatment of major depression, signalling/molecular mechanisms underlying responses in major depression and identification of suitable therapeutic targets for drug development.Consulted on different nanoparticles designed as drug carriers in their applicability for treatment of psychiatric disorders without compromising neurogenesis and neurodevelopment.Consulted on methods employed in pharmaceutical and cosmetic industries, and academic research for development of robotised testing platforms.Consulting on continuous increase in reputation and sales of periodicals.
|Year: 1999||Degree: PhD||Subject: Molecular Cell Biology||Institution: Institute of Molecular Biology, Bulgarian Academy of Sciences|
|Year: 1990||Degree: MSc||Subject: Biotechnology||Institution: Faculty of Biology, Sofia University, Bulgaria|
|Year: 1989||Degree: BSC||Subject: Biotechnology||Institution: Faculty of Biology, Sofia University, Bulgaria|
|Years: 2012 to Present||Employer: Undisclosed||Title: Director||Department:||Responsibilities: He is responsible for the general running of the company, provides editorial support for scientific journals and design of new formulations for skin care products.|
|Years: 2010 to Present||Employer: Undisclosed||Title: Editor-in-Chief||Department:||Responsibilities: Responsible for identifying suitable topics for volumes of the Advances in Protein Chemistry and Structural Biology in order to increase the reputation and sales of this periodical, assessing and editing contributions to the journal.|
|Years: 2011 to 2012||Employer: Rostock University||Title: Visiting Consultant||Department:||Responsibilities: Consultations on interrelationship between complement system and clock genes.|
|Years: 2010 to 2013||Employer: College of Medicine, Swansea University||Title: Lecturer||Department: Neuropsychopharmacology||Responsibilities: Responsible for managing research projects in molecular psychiatry and psychopharmacology, teaching students, supervising academic related staff, undergraduate and postgraduate students working in the laboratory.|
|Years: 2007 to 2009||Employer: Cardiff University||Title: MRC New Investigator Award||Department: School of Medicine||Responsibilities: Identified molecular mechanisms that regulate resistance of brain tumors to immuno- and chemotherapy and designed therapeutic peptides for their sensitisation to clearance by immune system.|
|Years: 2003 to 2007||Employer: Cardiff University||Title: Research Fellow||Department: School of Medicine||Responsibilities: Discovered novel roles of CD59 in immunotherapy.|
|Years: 1999 to 2003||Employer: London Research Institute||Title: Research Fellow||Department: Human Cytogenetics Laboratory, Cancer Research UK||Responsibilities: Human Cytogenetics Laboratory, Cancer Research UK
Discovered new mechanisms regulating the accumulation of amyloid plaques and control of expression of the Major Histocompatibility Complex in human.
|Years: 1991 to 1999||Employer: Bulgarian Academy of Sciences||Title: Research Associate||Department: Cell Proliferation and Differentiation Laboratory, Institute of Molecular Biology||Responsibilities: Revealed new mechanisms involved in the dynamic of the genome during cell cycle and nuclear compartmentalisation.|
|Years: 2011 to 2011||Agency: Medical Research Council, UK||Role: Grant reviewer||Description: He served as a grant reviewer.|
|Years: 2013 to 2013||Agency: Agency for Health Quality and Assessment of Catalonia (AHQAC), Barcelona, Spain||Role: Grant reviewer||Description: He served as a reviewer on three grant applications.|
|Years||Country / Region||Summary|
|Years: 2011 to 2012||Country / Region: Germany||Summary: He carried out consultations on manipulation of the interrelationship between complement system and clock genes in ADHD as a strategy for a therapy.|
|Years: 2012 to 2013||Country / Region: Kuwait||Summary: He consulted on biomarkers for the response to drug treatment of major depression. Further analyses on signalling/molecular mechanisms underlying responses in major depression and identification of suitable therapeutic targets for drug development were undertaken.|
|Years: 2010 to 2012||Country / Region: Bulgaria||Summary: He consulted on different nanoparticles designed as drug carriers in their applicability for treatment of psychiatric disorders without compromising neurogenesis and neurodevelopment.|
|Years: 2013 to 2013||Country / Region: Switzerland||Summary: He consulted on methods employed in pharmaceutical and cosmetic industries, and academic research for development of robotised testing platforms.|
|Years: 2006 to 2006||Country / Region: Russia||Summary: He consulted on satellite DNA binding drugs.|
|Associations / Societies|
|- Member of the New York Academy of Sciences
- Member of the Network of Healthcare Advisors
- Member of the International Complement Society
Cell cultures, including primary and stem cells
Cytotoxicity and immunocytotoxicity assays
Design of oral and i.v. formulations of immunotherapeutics
DNA/RNA extraction and manipulation
Design and manipulation of recombinant nucleic acids
Biological characterisation of nanoparticles for drug delivery
Molecular cloning and transfection
Protein expression, purification and characterisation of recombinant and native proteins
Protein-DNA interactions (Chromatin Immunoprecipitation)
Phage-display library for selection of therapeutic peptides and identification of receptors
Design of therapeutic peptides/proteins for immunotherapy
Blood cells purification, stimulation and analysis
Immunocytochemistry and immunohistochemistry
Fluorescent in situ hybridisation
|Awards / Recognition|
|Medical Research Council UK, New Investigator Award|
|Publications and Patents Summary|
|Published over 60 peer-reviewed articles in well-respected and highly reputable journals plus several invited talks and plenary talks and book chapter.
Filed one patent application.
|Expert Witness Experience|
|BUSINESS DEVELOPMENT AND CONSULTING EXPERIENCE
Developed successful projects for a new private molecular psychiatry laboratory for a client in Kuwait
Improved the reputation and sales of Advances in Protein Chemistry and Structural Biology, Elsevier, New York
Reviewed grants for the Medical Research Council UK, Alzheimer’s Society UK and the Agency for Health Quality and Assessment of Catalonia (AHQAC), Barcelona, Spain
Consulted on suitability of different nanoparticles designed as drug carriers for treatment of psychiatric disorders without compromising neurogenesis and neurodevelopment
|Training / Seminars|
|Editor of a number of books, including Inflammation in Neuropsychiatric Disorders, Protein-Nucleic Acids Interactions, Organisation of Chromosomes, Protein Structure and Diseases.|
|Expert's background and expertise suits perfectly pharmaceutical industries interested in the development of therapeutics for the treatment of neurodevelopmental and neurodegenerative disorders, and for cancer immunotherapy. He has also experience in consulting companies for the development of robots for use in chemical, pharmaceutical, and biotechnology industries and academic research. Running his own company in scientific publishing, antibody sales, and development of skin care products, he has developed customer focused attitude with excellent communication, leadership and influencing skills. Being editor-in-chief of a scientific periodical, Expert considerably increased the reputation and sales of this journal.|
|Other Relevant Experience|
|- research and advise on alterations in signalling pathways/metabolism in psychiatric, neurological disorders and tumours and ways of exploring these alterations for therapeutic benefit
- design of processes for creation of robotised platforms for pharmaceutical and cosmetic industries, and academic research
- applicability of drug carriers for treatment of developmental psychiatric disorders
Proven ability to manage through others.
Strong decision making and problem solving skills
Able to motivate and lead others in a team environment
|English||He is fluent in English language|
|Bulgarian||He is fluent in Bulgarian language|
|Russian||He is fluent in speaking and reading, and intermediate in writing in Russian language|
Fields of Expertise
C5a peptide, neuropharmacology, neurobiology, neuropsychopharmacology, neurotoxicology, active pharmaceutical ingredient, cancer immunotherapy, neuropsychology, neurodegenerative disease, psychopharmacology, neuropsychiatry, immunopharmacology, systemic immunity, cancer immunology, biological buffer, gene therapy vector purification, epitope mapping, bioanalytical chemistry, amyloid plaque, in vitro neurotoxicology, cell lysis, neuroblastoma, oncogene, antitumor drug, polyclonal antibody, cancer chemotherapy, tumor biology, protein biology, neuroimmunology, molecular neurobiology, immunobiology, human genome, genome, developmental biology, cancer biology, biological antioxidant, polyclonal antiserum, immunocytochemistry, biotin-avidin technology, biocompatibility, cancer, cancerous tumor, cellular immunology, cancer chemotherapeutic agent, cytotoxicity, cellular immunity, oncology, neuroscience, neuron, molecular biology, immunotherapy, genetics, genetic engineering, chronobiology, chromosome, cancer treatment, biology, biochemistry, antigen, Alzheimer's disease