Expert in Neurobiology, Neurodegenerative and Vascular Disorders, Estrogen-mediated Vascular Modulation
Expert ID: 728818 United Kingdom
One of his research projects was to determine how Ca2+ dysregulation can contribute to the pathophysiology of pre-eclampsia, a serious complication during the mid/third trimester of pregnancies. By using calcium imaging and electrophysiological techniques he characterized Ca2+ signalling in vascular endothelial and smooth muscle cells.
As Ca2+ is one of the key regulators of nitric oxide (NO) synthase NOS he additionally analyzed NOS signalling in tissue obtained from pregnant women affected by pre-eclampsia.
The Expert is currently investigating the mechanisms underlying various neurodegenerative diseases such as Alzheimer’s (AD), Parkinson (PD), Huntington disease (HD) or Prion disease all of which exhibit a progressing neuronal cell death. Here he is interested in modulation of ion channels (potassium, sodium, calcium) contributing to neuronal dysfunction. NO production from inflammation and resulting oxidative stress is also a significant factor in AD, PD, multiple sclerosis (MS) and HD and currently studies using cell culture and Drosophila models of HD being conducted.
The Expert has conducted intensive research in vascular biology including modulation of vascular tone by regulation of calcium homeostasis. Calcium (Ca2+) enters the cytoplasm of vascular smooth muscle and endothelial cells via various pathways (calcium channels, intracellular calcium stores) and dysfunction of these pathways contribute often to vascular diseases such as hypertension.
The Expert is investigating physiological effect of NO on auditory functions. Here he has characterized the involvement of NO in auditory processing as mediated in the auditory brainstem. He is applied a fluorescent method to detect NO levels upon neuronal activity by using a rhodamine-based chromophore diaminorhodamine-4M (DAR-4M). Several different nuclei are involved in sound source localization (medial superior olive (MSO), lateral superior olive (LSO), the superior-paraolivary nucleus (SPN) and nuclei of the lateral lemniscus (NLL)) and signal transmission encoded by action potential firing is depending on the action of various ion channels (e.g. potassium, sodium). His expertise in physiological regulation of these mechanisms has also been extended to investigate pathological alterations occurring during neurodegenerative diseases (e.g. tinnitus). Different potassium channels have been implicated in degenerative/apoptotic signalling and by using electrophysiological methods (patch clamp technique) the involvement of these ion channels can be characterized.
A general involvement of nitric oxide (NO) has been documented in many neurodegenerative disorders and his primary aim is to investigate how this free radical gas is involved in oxidative stress-mediated neuronal cell death. The amount of cellular oxidative stress is determined by a balance of physiological antioxidant systems (Superoxide Dismutase, Catalase, Glutathione Peroxidase) and the generation of reactive oxygen species (e.g. Superoxide generated by Mitochondria, Xanthine Oxidase, NAD(P)H Oxidase, NOS). Thus, if this balance is shifted towards enhanced generation of reactive oxygen species (ROS) with lacking antioxidant defense, cells experience detrimental effects such as lipid peroxidation or DNA damage.
|Year: 2001||Degree: PhD||Subject: Vascular Physiology||Institution: King's College London, UK|
|Year: 1996||Degree: MSc||Subject: Biophysics||Institution: Humboldt University Berlin, Germany|
|Years: 2006 to 2013||Employer: MRC Toxicology Unit, Leicester, UK||Title: Senior Invstigator Scientist||Department:||Responsibilities: Leading research projects, Conducting research experiments, Supervision of staff.|
|Years: 2004 to 2006||Employer: University Heidelberg, Germany||Title: Postdoctoral Scientist||Department:||Responsibilities: Conducting research experiments|
|Years: 2002 to 2004||Employer: Max Planck Institute Tuebingen, Germany||Title: Postdoctoral Scientist||Department:||Responsibilities: Conducting research experiments|
|Years: 2001 to 2002||Employer: King's College London, UK||Title: Postdoctoral Scientist||Department:||Responsibilities: Conducting research experiments|
|Years: 2013 to Present||Employer: Undisclosed||Title: Group Leader||Department:||Responsibilities: Leading competitive research in the area of degenerative diseases, including signaling involved in Nitric Oxide toxicity. His team consists of post-doctoral and student staff.|
|Years||Country / Region||Summary|
|Years: 1996 to 2002||Country / Region: UK||Summary: He studied during his PhD and postdoctoral employment vascular disorders investigating abnormalities in calcium regulation and nitric oxide signalling.|
|Years: 2006 to 2010||Country / Region: UK||Summary: He studied the underlying mechanisms of neurodegenerative disorders, such as AD or PD and the involvement of ion channel dysfunction related the neuronal cell death. In particular, oxidative stress and nitric oxide involvement are key areas of interest.|
|Associations / Societies|
|He is a member of the Physiological Society, UK, and Society for Neuroscience, USA.|
|2013-date: Group Leader at the Medical Research Council Toxicology Unit|
|Awards / Recognition|
|He received the MRC ARS award in 2009.|
|Publications and Patents Summary|
|He has 40 publications in high profile peer-reviewed journals, including 3 publications in Neuron and 2 in Nature.|
|English||High proficiency as he lived over 16 years in the UK.|
|Russian||8 years of school language.|
Fields of Expertise
cardiovascular physiology, cardiovascular research, cardiovascular system, potassium channel blocker, vascular biology, vascular disease, nitric oxide, nitric oxide donor, nitrous oxide, neuroscience, nerve, nervous system, nervous system disease, Alzheimer's disease, central nervous system disease, dementia, neurobiology, Parkinson disease, prion disease, neurodegenerative disease, intracellular calcium, calcium channel, calcium homeostasis, auditory disease, auditory neurophysiology, auditory physiology, neurophysiology, physiology, tinnitus, oxygen radical biochemistry, oxidative stress, auditory neuroscience, vasoconstrictor agent, sodium channel blocker, calcium channel blocker, nerve stimulation, nerve regeneration, endothelial cell, cell membrane, calcium