Expert Details

Expert in Organic Synthesis, Organometallics, Prostaglandins, Vitamin D, Catalysis

Expert ID: 108405 Delaware, USA

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ORGANIC SYNTHESIS; ORGANIC REACTIONS; NATURAL PRODUCT. Expert and his research group have successfully carried through many total syntheses of natural products. In addition, he has originated, reduced to practice, and published many new methods for effecting organic transformations. He also has a file of literature reactions that is more extensive than REACS or SYNLIB, and can be searched more quickly.

ASYMMETRIC SYNTHESIS; ENANTIOSELECTIVE CATALYSIS. With his research group, he has developed new methods for the enantioselective preparation of organic intermediates. He has 30 years of direct research experience and a thorough working knowledge of the relevant chemical literature. He is also an expert in prostaglandin synthesis.

TRANSITION-METAL-MEDIATED ORGANIC REACTIONS. Expert and his research group have developed several new methods for transition-metal-mediated carbon-carbon formation.

CATALYSIS. Expert and his research group have developed several new methods for transition metal complex catalysis of organic reactions. They have experience in computer-based modeling of transition metal complexes and transition states, and in the use of those techniques to design improved catalysts.


He has worked with a major pharmaceutical company on improving the yield of Rh-mediated labeling.He has worked with the chemical process department of a major pharmaceutical company on developing new synthetic routes to desired chemical compounds. He has worked with a diversified chemical manufacturer on improving the manufacturing process for a catalyst.He has worked with the chemical process department of a major pharmaceutical company on improving the enantioselectivity of a synthesis.

Expert may consult nationally and internationally, and is also local to the following cities: Philadelphia, Pennsylvania - Allentown, Pennsylvania - Reading, Pennsylvania - Bethlehem, Pennsylvania - Lancaster, Pennsylvania - Trenton, New Jersey - Camden, New Jersey - Wilmington, Delaware - Baltimore, Maryland - Alexandria, Virginia

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Education

Year Degree Subject Institution
Year: 1974 Degree: PhD Subject: Organic Chemistry Institution: Columbia University
Year: 1970 Degree: BS Subject: Chemistry Institution: Stanford University
Year: 1975 Degree: Postdoctoral Subject: Asymmetric Organic Synthesis Institution: University of Wisconsin

Work History

Years Employer Title Department Responsibilities
Years: 2013 to 2018 Employer: University of Delaware Title: Professor Emeritus Department: Responsibilities: reading, writing about organic synthesis
Years: 1993 to 2013 Employer: University of Delaware Title: Professor Department: Responsibilities: organic synthesis research group
Years: 1984 to 1993 Employer: University of Delaware Title: Associate Professor Department: Responsibilities: organic synthesis research group
Years: 1982 to 1984 Employer: University of Delaware Title: Assistant Professor Department: Responsibilities: organic synthesis research group
Years: 1977 to 1982 Employer: Vanderbilt University Title: Assistant Professor Department: Responsibilities: organic synthesis research group

Government Experience

Years Agency Role Description
Years: 1982 to Present Agency: Department of Defense Role: Consultant Description:

International Experience

Years Country / Region Summary
Years: 1986 to 2000 Country / Region: Japan Summary: Several trips, visiting universities, participating in scientific meetings.
Years: 1987 to 2000 Country / Region: Western Eurpoe Summary: Several trips, visiting universities, participating in scientific meetings.
Years: 1993 to 1999 Country / Region: PRC Summary: Two trips, visiting universities, participating in scientific meetings.
Years: 2000 to 2000 Country / Region: Poland Summary: One trip, visiting a research institute, participating in a scientific meeting.
Years: 1997 to 1997 Country / Region: Thailand Summary: One trip, participating in a scientific meeting.

Career Accomplishments

Associations / Societies
He is a member of the American Chemical Society and the American Association for the Advancement of Science.
Professional Appointments
He is a Reviewer: Journal of the American Chemical Society, Journal of Organic Chemistry, Organic Letters, Tetrahedron Letters and Tetrahedron.
Awards / Recognition
He is a Fellow of the American Association for the Advancement of Science and has received Research Grants from NIH, NSF and Petroleum Research Fund.
Publications and Patents Summary
He has published 205 research papers on organic synthesis and organometallic catalysis, five book chapters, four monographs, and two undergraduate laboratory textbook. He is the author of the weekly online resource Organic Highlights

Additional Experience

Expert Witness Experience
He has served as an expert witness on patent cases, including preparing expert witnesses, participating in depositions, and testifying.

1. 1992-93 Expert witness
Chemical valuation of petroleum distillates; testified at hearing

2. 1993-94 Expert witness
Chemical processes: methods for preparing diltiazem; deposed, testified at ITC hearing

3. 2000 Expert Witness
Chemical nomenclature of prostaglandin derivatives; expert report, deposed.

4. 2000 Expert Witness
Chemical nomenclature of prostaglandin derivatives

5. 2000-01 Expert Witness
Chemical processes: methods for preparing quinolone antibiotics; expert report, deposed.

6. 2007 Expert Witness
Prostaglandin derivatives expert report, deposed

7. 2009 Expert Witness, expert report, case settled

8. 2010 Expert Witness,
Vitamin D derivatives; case settled.

9. 2011 Expert Witness,

10. 2014-2015 Department of Justice: Duty classification of imported chemicals

11. 2015 prostacyclin derivatives

12. 2016 roflumilast expert report, deposed

13. 2017 consultation

14. 2017 tetracycline synthesis claim construction

Training / Seminars
He has taught Intermediate Organic Chemistry, a bridge between the undergraduate and the graduate course, at several industrial sites in this area, usually in groups of 15 or 20 at a time.
Other Relevant Experience
He is an expert in the use of computational methods to design organometallic catalysts.

Language Skills

Language Proficiency
French
German
Japense

Fields of Expertise

asymmetric synthesis, catalysis, enantioselective catalysis, natural product, organic chemistry, organic reaction, organic synthesis, palladium, transition-metal-mediated organic reaction, transition metal catalysis, transition metal catalyst, chemical intermediate, enantiomer, metallic element, enantioselective heterogeneous catalysis, palladium homogeneous catalysis, acid catalysis, alcohol compound, chemical reagent, precious metal, Friedel-Crafts reaction, molecular chirality, atropine, cyclopentene, cyclopentadiene, hexachloroethane, scopolamine, transition element chemistry, platinum chemistry, osmium chemistry, hafnium chemistry, samarium chemistry, silver chemistry, palladium chemistry, rhodium chemistry, ruthenium chemistry, zirconium chemistry, copper chemistry, cobalt chemistry, manganese chemistry, chromium chemistry, titanium chemistry, tetrahydrofuran, organic reaction mechanism, phenolic compound, diene, drug, organic compound, terpene, zirconium, tropane, transition element, terpene synthesis, stereochemistry, shape-selective catalysis, samarium, rhodium, quinone, qualitative organic chemistry, polystep catalysis, piperidine, organometallic compound, organometallic chemistry, organic acid, nitrogen organic compound, natural organic compound, morphine, lanthanum, hydrocarbon chemistry, heterocyclic compound, halogenated hydrocarbon, glycol compound, europium, ethylene oxide, dibasic organic acid, crown ether chemistry, cobalt, catalytic oxidation, catalytic hydrogenation, catalyst, catalysis reagent, carbocation chemistry, carbanion chemistry, caffeine, biradical, biochemistry, asymmetric induction, aromatic hydrocarbon, aromatic acid, amine, amide, alkaloid, aliphatic polyene, aliphatic hydrocarbon, aliphatic acid, aldehyde, acid

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