Expert Details

Expert in Personalized Medicine, Genomics, Proteomics, Bioinformatics, Oncology, Biotechnology, IBD

Expert ID: 723778 Massachusetts, USA

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As the director of the Beth Israel Deaconess Medical Center Genomics and Proteomics Center and of the Dana Farber/ Harvard Cancer Center Proteomics Core, Expert has ample expertise in bioinformatics, since each of these facilities includes a whole core for bioinformatics. Expert supevises a group of bioinformaticians and is himself heavily involved in evaluating bioinformatics software tools, analyzing genomic and protomic data using bioinformatics and developing novel bioinformatics software. He has applied bioinformatics analysis for many clincal, translational and basic research questions in oncology, immunology, cardiovascular disease, diabetes, obesity and autoimmune diseases. He is continuously evaluating bioinformatics software from many companies.

Expert is the director of the Beth Israel Deaconess Medical Center Genomics Center. He has years of experience in all types of genomics applications. His Center provides service to academic and industry labs for transcriptional profiling, genotyping, tiling arrays, exon arrays, methylation, real time PCR, microRNAs and any other genomic application. The Center has instrumentation from all major suppliers such as Affyemtrix, Illumina, Nanogen, Agilent, GE Healthcare, ABI, MJR, Perkin Elmer etc. He is in charge of evaluating and selecting instrumentation and supplies for all genomic studies. His expertise in genomics reaches through all major clinical, translational and basic science applications. A major focus of the genomics applications are in the areas of cancer, immunology, inflammation, autoimmune diseases, obesity, diabetes and cardiovascular diseases. A major effort is towards introducing new genomic technologies into the clinical lab and apply genomics to personalized medicine.

As the director of the Beth Israel Deaconess Medical Center Genomics Center and of the Dana Farber/ Harvard Cancer Center Proteomics Core Expert has ample expertise in all aspects of proteomics including protein fractionation, mass spectrometry, ELISA based assays, protein microarrays, microfluidics, surface plasmon resonance and high throughput assays utilizing robotics and various automation equipment. His center has instrumentation from all major suppliers including ABI, Thermo, Waters, Beckman, Dionex, Agilent, GE Healthcare, Caliper etc. A major focus of Expert is the discovery of biomarkers for various diseases using bodily fluids such as blood, urine and cerebrospinal fluid as well as tissues. Major disease areas for biomarker discovery in his center include cancer of the breast, kidney, liver, ovary, prostate, brain, leukemia, lymphoma, as well as hepatitis C virus infection, diabetes, obesity, inflammation, autoimmune diseases, and cardiovascular disease.

As the director of the Beth Israel Deaconess Medical Center Genomics Center and of the Dana Farber/ Harvard Cancer Center Proteomics Core Expert is involved in evaluating all types of instrumentation for genomics, proteomics, cell biolopgy, automation, high throughput assays, molecular biology, drug screening etc. He has more than 20 years experience in research. His center is testing and evaluating many new instruments and technologies as a beta test site.

Expert has strong expertise in gene therapy. He is applying gene therapy approaches using adenovirus, lentivirus, retrovirus and naked DNA or RNA for various basic science questions and as potential therapies for diseases such as cancer.

Expert has over 30 years of experience in oncology and cancer research. He has published many manuscripts related to
glioblastomas, prostate cancer, renal cell cancer, ovarian cancer and multiple myeloma, some of them groundbreaking discoveries related
to cancer development and progression. He is an expert in diagnostics of cancer as well as in the molecular mechanisms and signaling
pathways involved in cancer development and progression. His expertise extends towards developing and testing novel anti-cancer
therapies. He has majise in genomic and proteomic approaches to cancer and the bioinformatic and systems biology analysis of
such data.

He has been a member of the Scientific Advisory Board of Cardion. He is routinely consulting investment companies on biotechnology and pharma companies.He is on the scientific advisory board of Karyon Therapeutics.He is the Chief Scientific Advisor for BananaLogix

Expert may consult nationally and internationally, and is also local to the following cities: Boston, Massachusetts - Worcester, Massachusetts - Springfield, Massachusetts - Lowell, Massachusetts - Cambridge, Massachusetts - Brockton, Massachusetts - New Bedford, Massachusetts - Hartford, Connecticut - Manchester, New Hampshire - Providence, Rhode Island

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Education

Year Degree Subject Institution
Year: 1986 Degree: PhD Subject: Chemical Immunology Institution: Weizmann Institue of Science and Technology
Year: 1980 Degree: MSc Subject: Biochemistry Institution: Federal Institute of Technology, Zurich (ETHZ)

Work History

Years Employer Title Department Responsibilities
Years: 1990 to Present Employer: Undisclosed Title: Associate Professor of Medicine Department: Medicine/Interdisciplinary Medicine and Biotechnology Responsibilities: He is the director of the Beth Israel Deaconess Medical Center Genomics Center and of the Dana Farber/Harvard Cancer Center Proteomics Core as well as Co-Director of the Beth Israel Deaconess Medical Center Center for Individualized Medicine.
Years: 1987 to 1990 Employer: Whitehead Institute for Biomedical Research Title: Postdoctoral fellow Department: Responsibilities: Research on immune system gene expression
Years: 1986 to 1987 Employer: Rorer Biotechnology Research Center Title: Senior Scientist Department: Responsibilities: Brain tumor research

Government Experience

Years Agency Role Description
Years: 1990 to Present Agency: National Institues of Health Role: Reviewer in Study Sections Description: He has over the last 17 years been a member of various study sections for reviewing grants.
Years: 1997 to Present Agency: National Science Foundation Role: Reviewer in Study Section Description: He has been reviewing grants for the NSF.
Years: 1991 to Present Agency: National Institues of Health Role: Grant Awardee Description: He has for the last 16 years received grants from the NIH for his research.

International Experience

Years Country / Region Summary
Years: 1975 to 1980 Country / Region: Switzerland Summary: He was studying at the Federal Institute of Technology, Zurich (ETHZ) and did his diploma (MSc) in biochemistry. He then worked fro one year as a research associate at the same institution.
Years: 1980 to 1985 Country / Region: Israel Summary: He did his PhD at the Weizmann Institute of Science and Technology in Rehovot in immunology.

Career Accomplishments

Associations / Societies
Professional Societies:

American Society for Microbiology (1994-);
American Diabetes Association (1995-1998);
Association of Immunologists (1996-1999);
American Association for the Advancement of Science (1997- );
American Society for Biochemistry & Molecular Biology: GLG Scholar (2004- );
American Association for Cancer Research (2005- );
Proteome Society (2005- );
Protein Society (2005- );
USHUPO Member (2006- )
Professional Appointments
Editor-in-Chief, Open Proteomics Journal
Awards / Recognition
Awards and Honors:

1983: UICC-International Cancer Research Technology Transfer (ICRETT) Fellowship;
1984: Feinberg Graduate School Award for achievements in Ph.D. studies;
1985: Leukemia Society of America Fellowship;
1995: American Diabetes Association Research Award;
1996: Juvenile Diabetes Foundation Research Award;
1997, 1998: The Brain Tumor Society Research Award and The Alexis A. Boss Chair of Research;
1998: CaP CURE Research Award;
2007: Prostate Cancer Foundation Research Award;
2009: Prostate Cancer Foundation Research Award
Publications and Patents Summary
He has over 150 publications, 4 issued patents and four pending patents.

Additional Experience

Training / Seminars
Expert has developed seminars for oncology, genomics, proteomics and bioinformatics for various national and international meetings and courses as well as investors.
Vendor Selection
As director of a Genomics and Proteomics Center he has ample experience in locating vendors and suppliers for all types of instrumentation and consumables in the life sciences.
Marketing Experience
As the director of the BIDMC Genomics Center and of the Dana Farber/Harvard Cancer Center Proteomics Core Expert has ample experince in marketing services to the academic and pharmaceutical industry. He has developed marketing material that is being distributed and he has developed websites to market the services. He has also implemented a seminar series to market the services to the research community.
Other Relevant Experience
He has expertise in oncology, translational medicine, genomics, proteomics, and bioinformatics with a particular focus on cancer, inflammatory diseases, and autoimmune diseases. He is also very experienced in signal transduction and has expertise in drugs targeting signaling pathways such as various kinase inhibitors. Expert is applying systematic and comprehensive functional genomics and proteomics strategies for transcriptional profiling, high throughput genotyping, proteomics, and drug screening to define disease mechanisms at a molecular level and to identify novel prognostic and predictive markers as well as new drug targets in human disease such as cancer. He is involved in translational and individualized medicine. Expert is a Founder of Karyon Therapeutics, TBK Pharmaceuticals and Tolerance Pharmaceuticals which merged into Cardion and has consulted for various companies.

Language Skills

Language Proficiency
German He was born in Germany and is fluent in German.
Hebrew He is fluent in Hebrew, since he has lived in Israel for six years.
French He knows French due to extensive courses and multiple visits to french-speaking countries.
Portuguese He understands and speaks reasonably well Portuguese.

Fields of Expertise

bioinformatics, biotechnology, molecular biology, genomics, genome, clinical genetics, DNA technology, eukaryotic gene, gene, gene expression, genetic engineering, genetic sequencing, genetics, genotype, human genetics, human genome, molecular genetics, proteome, biomedical instrumentation, bioinstrumentation, biomedical application, biomedical diagnostic instrumentation, biomedical instrument, gene therapy, pharmacogenetics, ovarian neoplasm, translational medicine, genotyping, cancer, cancer biology, cancer diagnosis, cancer research, computational biology, epithelial cell, genitourinary oncology, kidney cancer, oncogene, oncology, pancreatic cancer, prostate cancer, systems biology, tumor biology, urologic cancer, individualized medicine, type 2 diabetes, type I diabetes, inflammatory bowel disease, gastrointestinal cancer, cancer prognosis, diabetic nephropathy, brain tumor, medical genetics, pediatric oncology, genotyping software, immune system, molecular diversity, combinatorial chemistry, vascular endothelial cell growth factor, peptide mimetic, genetic disease, stomach cancer, pancreatic islets, medical laboratory equipment, biological cell adhesion, clinical laboratory equipment, drug clinical trial, inflammation, medical device testing, antitumor drug, lung cancer, skin cancer, reproductive genetics, immunogenetics, cytogenetics, autoimmune disease, gynecologic drug development, drug development, pharmaceutical industry, liver cancer, computer-aided drug design, genetic mutation process, Crohn's disease, breast cancer, biomedical device, DNA, drug, ulcerative colitis, monoclonal antibody, medical device, immunology, heredity, genetic manipulation, drug screening, diabetes, chromosome, cancer treatment, biomedical sensor, biomedical engineering, biomedical chemical sensor

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