Intellex Acquires Expert by Big Village

We're thrilled to announce that Intellex has acquired Expert by Big Village, effective March 22, 2024. This strategic move enhances our capabilities and strengthens our commitment to delivering exceptional solutions to our customers.

Stay tuned for more updates on how this acquisition will benefit our clients and experts.

For inquiries or more information, please contact us at info@intellex.com.

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Expert Details

Synthetic Organic Chemistry for Diagnostics, Pharma, and Biotechnology

ID: 733716 Pennsylvania, USA

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Expert developed and successfully managed a 14-step synthetic method for a patentable alternative to a fluorescent probes.

Expert has developed 4 synthetic methods for small molecule linker conjugates (with a total of 15 steps) for antibody production and synthesis that are currently being used in late stage development and manufacturing of an in vitro diagnostic. Product launch is expected by 2018.

Expert has perfected a synthesis of an antigen-linker conjugate that overcame severe solubility and purification issues. He synthesized material for research, development and manufacturing. Product launch is expected in late 2017.

Expert has 20 publications and 13 patents or patent applications related to drug discovery and development in the following areas: antineoplastic agents, antiviral agents, CNS drugs, nonaddictive pain treatment, and antimicrobial agents.

Expert has developed self-assembling cytotoxins, a combintarial approach to target selective drug synergism.

Expert has optimized the purity in scaleup synthesis of a small molecule for pain treatment candidate, which has shown highly significant activity in clinical trials and has been awarded fast-track designation in a second trial in late 2016. He has also developed and completed synthetic methods for drug impurities to support stability studies.

The structure determination and synthetic procedure of a chiral drug candidate developed by Focus Synthesis was used in the client A’s pre-IND documentation to support a successful pre-IND meeting with the FDA that allowed clinical trials to begin in Q4 2014.

Expert has determined the structure of a highly unusual drug metabolite through synthesis of deuterated drug analogs, interpretation of the MS, and chemical synthesis.

As a consultant, Expert conducts the following:

Developing workarounds for synthetic chemistry and purification challenges, including redesign of molecules where needed.
Development of scalable synthetic strategies for diagnostic tool molecules and drug candidates.
Development of successful synthetic strategies for diagnostics, including a macrocycle requiring 14 steps.
Writing patent applications (with attorney).
Preparation of grant applications.
Design of patentable, synthetically accessible alternatives to existing bioactive molecules and fluorescent probes.
Determination of drug candidate metabolite structures.
Determination of structure of chiral molecules.
Development of novel, patentable ideas for molecular scale electronics.

Education

Year Degree Subject Institution
Year: 1982 Degree: Ph.D. Subject: Bioorganic Chemistry Institution: Columbia University
Year: 1980 Degree: MS Subject: Bioorganic Chemistry Institution: Columbia University
Year: 1978 Degree: BA Subject: Chemistry Institution: Princeton University

Work History

Years Employer Title Department
Years: 2017 to Present Employer: Undisclosed Title: Independent Chemistry Consultant Department:
Responsibilities:
Expert undertakes synthetic organic chemistry consultation for diagnostic, pharma, and biotech companies.
Years Employer Title Department
Years: 2004 to 2016 Employer: Focus Synthesis LLC Title: President, CEO, and founder Department: Chemistry
Responsibilities:
Expert was responsible for developing synthetic methods and designing patentable molecules and methods for diagonistics, pharma, biotech, and nutraceutical companies.

Career Accomplishments

Associations / Societies
American Chemical Society
Awards / Recognition
Expert has been awarded several significant grants.
Publications and Patents Summary
Expert has had 20 articles published in Science, Nature, PNAS, JACS, and other journals related to drug discovery.

Expert has 13 patents and patent applications related to drug discovery and development in diabetes, cancer, viral infections, microbial infections, and hyperbilirubinemia. He has 4 additional patent applications submitted or in preparation for diagnostics, drug discovery, and nutraceuticals.

Additional Experience

Vendor Selection
Expert has vetted specialty and research chemical vendors in the U.S., India, China, the UK, and Canada.
Marketing Experience
Expert has been responsible for the marketing of catalog chemicals.

Expert has designed websites with over 2,000 research chemicals, searchable by chemical structure, CASRN, and chemical name. He has undertaken listing in multivendor catalogs (CHEMCATS, ACD, emolecules, chemexper, ChemAXS and others), which was found to be the most effective means of marketing chemical building blocks.

Expert is skilled and experienced in Google adwords and vendor booths at meetings. He has established successful vendor agreements with emolecules, Activate Scientific, Sigma Aldrich, and Chemnavigator.
Other Relevant Experience
Expert's areas of consulting expertise include:
Synthetic organic chemistry for in-vitro and POC diagnostics
Applications: GI, nutritional deficienty, DNA sequencing
Molecules: Conjugates for antibody production, steroids, fluorescent probes, PCR tools, nucleotides, cryptates, nanotechnology.
Synthetic organic, medicinal, discovery, and development chemistry for Pharma
Applications: CNS, cancer, and pain.
Synthetic chemistry for nutraceuticals

Language Skills

Language Proficiency
German Can translate chemical journal articles to English.

Fields of Expertise

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