Expert Details
Wound Healing, Combat Casualty Care, Hemostasis, Collagen, Pressure Ulcers, and Keloids
ID: 107800
Virginia, USA
Having over 40 years of experience in the area of tissue injury, inflammation, and repair, Expert has worked with injuries to tissues and organs throughout the body. He can answer detailed questions on connective tissue, granulation tissue, scar tissue, and fetal tissue as well as medical adhesion processes.
Expert's lab has designed and carried out a variety of human, animal, and cell culture studies to analyze the effect of growth factors on wound healing, epithelization, contraction, inflammation, and collagen metabolism. He is knowledgeable of endothelial cells as well as epithelial cells.
Expert has studied how keloid fibroblasts exhibit an altered response to TGF-beta.
The Laboratory of Tissue Repair has also been involved with a variety of industrial pharmaceutical companies in studies focused on the biology and biochemistry of chronic ulcer formation such as diabetic, pressure, and venous stasis ulcers. These studies have found an increased level of interleukin-beta and collagenase (MMP-1) in non-healing ulcers; once these wounds are treated with specialized hydroactive dressings, the levels are reduced and the ulcers begin to heal. The laboratory has also reported recently that proteases such as elastase are present in these chronic ulcers and these enzymes are capable of degrading topically applied agents such as PDGF and TGF-beta.
Reviewed hospital records and patient depositions to prepare an Expert Witness statement used to settle out of court legal cases.Assisted in the preparation of NIH and Department of Defense research proposals.Consulted for Wound Care Products for TraumaCure and Oxygen BiotherapeuticsReviewed a wide variety of research and development projects for industry and provided expert advice and guidance.
Education
| Year | Degree | Subject | Institution |
|---|---|---|---|
| Year: 1972 | Degree: Postdoctoral | Subject: Postdoctoral Position | Institution: NIH - Cancer Institute |
| Year: 1969 | Degree: Ph.D. | Subject: Biochemistry | Institution: Georgetown University |
| Year: 1965 | Degree: B.S. | Subject: Biochemistry | Institution: Mt. St. Mary's University |
Work History
| Years | Employer | Title | Department |
|---|---|---|---|
| Years: 1972 to 2021 | Employer: (Undisclosed) University | Title: Professor of Biochemistry, Anatomy, and Emergency Medicine | Department: Department of Biochemistry and Molecular Biology |
Responsibilities:Wound healing research; hemostasis; combat casualty care; chronic skin ulcers; and medical student education. |
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Government Experience
| Years | Agency | Role | Description |
|---|---|---|---|
| Years: 1997 to 2000 | Agency: NIH | Role: Served as a Permanent Member, Surgery, Anesthesia and Trauma Study Sect. Ad Hoc Study Section Reviewer | Description: Review research proposals |
| Years: 1993 to 2018 | Agency: FDA | Role: Consultant | Description: General and Plastic Surgery Devices Panel of the Medical Devices Advisory Committee, Center for Devices and Radiological Health, Food and Drug Administration |
| Years: 2010 to 2018 | Agency: NIH | Role: CSR National Registry of Volunteer Reviewers | Description: Study section proposal reviews |
Career Accomplishments
| Associations / Societies |
|---|
| Expert is a founding member of the Wound Healing Society (Secretary and Board of Directors). He has also been a member of the American Society for Biochemistry and Molecular Biology, the New York Academy of Sciences, Sigma Xi, the Society for Experimental Biology and Medicine, the Plastic Surgery Research Council, and the Negus Award Committee for Excellence in Biochemical Research. At present, Expert is a member of the General and Plastic Surgery Devices Panel of the Medical Devices Advisory Committee, Center for Devices and Radiological Health, Food and Drug Administration. He is a senior member of the Wound Healing Society and a Fellow of the Johnson Center at VCU.. Member of the National Academy of Inventors. |
| Professional Appointments |
|---|
| Expert is an editor for Wound Repair and Regeneration and has reviewed for Analytical Biochemistry, Collagen and Related Research, Gastroenterology, Hepatology, Proceedings of Society for Experimental Biology and Medicine, American Journal of Physiology: Cell Physiology, Archives of Biochemistry and Biophysics, Journal of Clinical Investigation, Pediatric Research, International Journal of Radiation Biology, Laboratory Investigation, Connective Tissue Research, Science, Surgery, Annals of Surgery, and Journal of Plastic and Reconstructive Surgery. He has also served on several NIH study sections and served as a permanent member of the Surgery, Anesthesiology & Trauma Study Section of the General Medical Sciences Institute of the National Institute of Health. In addition, Expert has served as a consultant on the General and Plastic Surgery Devices Panel of the Medical Devices Advisory Committee, Center for Devices and Radiological Health, Food and Drug Administration from 1993 to the present. |
| Awards / Recognition |
|---|
| Teaching Excellence Award for the VCU School of Medicine. The US Army Medical Research and Materiel Combat Casualty Care Research Program Award for Excellence. In (Undisclosed)he received the Simon Brute Medal from Mount Saint Mary's University in recognition of presented by the National Alumni Association of Mount St. Mary’s University as recognition of the highest honor conferred upon an alum by the Association. Each recipient has distinguished himself through their careers, commitment to their community or service to their fellow man and whose recognition as a recipient of the award will bring honor to Mount St. Mary’s University. SPECIAL AWARDS, FELLOWSHIPS AND OTHER HONORS: NIH Pre-doctoral Trainee: Georgetown University NIH Postdoctoral Fellowship: National Cancer Institute, Laboratory of Physiology, NIH, Bethesda, Maryland Winner of Scholarship Contest, Senior Classification of the Educational Foundation of the American Society of Plastic and Reconstructive Surgeons, Inc. Medical College of Virginia, School of Medicine Outstanding Professor of Cell Biology J.C. Phillips Outstanding Leadership Award M-1 Medical Biochemistry Outstanding Teacher Award Chief’s Award for Outstanding Service and Commitment Forest View Volunteer Rescue Squad VCU School of Medicine Excellence in Teaching Award The US Army Medical Research and Materiel Combat Casualty Care Research Program Award for Excellence BIOL-361-901; Best Basic Science Lecturer M-1 Medical Biochemistry Outstanding Teacher Award Department of Biochemistry & Molecular Biology Outstanding Teacher Award Scientific Foundations of Medicine Outstanding Teacher Award Foundations of Disease Outstanding Teacher Award Symposium on Advanced Wound Care, Founders Award The Simon Bruté Medal Wound Healing Society Lifetime Achievement Award Member of the National Academy of Inventors. |
| Medical / Professional |
|---|
| Professor of Biochemistry & Molecular Biology, Anatomy and Emergency Medicine (Tenured). Virginia Commonwealth University Medical Center Associate Professor of Surgery, & Biochemistry (Tenured). Virginia Commonwealth University Medical College of Virginia 1979 - 2000 Assistant Professor of Surgery and Biochemistry Virginia Commonwealth University Medical College of Virginia 1972 - 1979 Member, Hand Management Center Virginia Commonwealth University Medical College of Virginia 1980 - 1991 Member, Massey Cancer Center Virginia Commonwealth University Medical College of Virginia 1977 - Present Director of the Laboratory of Tissue Repair 1972 – Present VCURES Senior Fellow, Director Wound Healing Section 1999-- Present Medical Biochemistry Course Director 2009 to Present VCU School of Medicine Curriculum Council 2010 to 2014 VCU School of Medicine Clinical Subcommittee 2014 to 2017 Institutional Animal Use and Care Committee 2014 to Present |
| Publications and Patents Summary |
|---|
| Expert has over 200 scientific publications and 15 patents. His paper in the journal of Biochemistry is the 20th most quoted publication. 20th Most Cited Article in Biochemistry; 1,510 citations. 25 Grants (past and present) 37 Major committee member 166 Invited Lectures 43 Journals (Past and present reviewer) US Patent in Hemostasis, Wound Care, High Pressure Blood Flow, and Use of Kaolin and Bentonite |
Additional Experience
| Expert Witness Experience |
|---|
| Expert has reviewed several litigation involving cases in the area of wound healing, pressure ulcers and traumatic injuries and provided expert statements and depositions. All of the cases were settled out of court based upon his summaries. |
| Training / Seminars |
|---|
| Expert has given many national and international lectures. |
| Vendor Selection |
|---|
| Expert has experience locating vendors of wound healing promoting agents, growth factors, dressings, pharmaceuticals, and wound care products. |
| Marketing Experience |
|---|
| He is the director of the Laboratory of Tissue Repair and is also the lead inventor on Wound Stat, the most efficient hemostatic agent available. |
| Other Relevant Experience |
|---|
| He served five terms on the Board of Directors and as President of the Wound Healing Society MEMBERSHIP - COMMUNITY ORGANIZATIONS: Knights of Columbus - Council Inside Guard Treasurer Financial Secretary Honorary Life Member Foster Parents Program for Newborns, Richmond Diocese Catholic Family Services (approved) Host Family, Irish Children's Summer Program Forest View Volunteer Rescue Squad - EMT-B Emergency Vehicle Operator Squad Leader / Attendant in Charge Vice President Crew Lieutenant Captain of the Night Crews Emergency Vehicle Operations Course Instructor Life Member Deputy Chief Staffing Lieutenant |
Fields of Expertise
wound healing, collagen, collagen synthesis, collagenase, fibrosis, wound care, wound dressing material, collagen research, chronic wound, human tissue repairing, cell culture, growth factor, chronic ulcer, keloid, trauma anesthesia, skin physiology, procurement of allograft, bone morphogenetic protein, electronic bone growth stimulator, skin irritant, recombinant platelet factor-4, revascularization, liver cirrhosis, skin transplantation, skin toxicity, vascular anatomy, fibrin glue, interleukin, human biology, lesion, biological regeneration, wound irrigation, skin structure, skin growth, platelet aggregation, vascular biology, veterinary wound healing, tumor biology, skin tumor, human tissue, blood vessel, tissue grafting, cellular regulation, vascular tissue, vascular graft, epithelium, medical adhesion, gelatin, tumor, culture, peptide, amino acid, trauma, protein, vascular surgery, vascular disease, tumor necrosis factor, tobacco smoke human health effect, surgical infection, skin disease, protein synthesis, protein metabolism, post-injury hypermetabolism, pathology, osteoarthritis, lymphocyte, glycoprotein, gene expression, gastrointestinal disease, epidermal growth factor, dermatotoxicology, cellular signal transduction, cell physiology, cell anatomy, ascorbic acid, aortic disease