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Enzyme Assay, Analytical chemistry, Protein purification
Enthusiastic, resourceful and innovative Scientist and Academician, offering over 18 years of well-honed research and teaching experience, with knowledge across the field of Chemical Biology, Biotechnology and Analytical science. Research focuses on chemical techniques to the study of biological systems…
Medicinal Chemistry, Drug Discovery, Organic Chemistry, Antibody-Drug Conjugates
Accomplished project leader with strong experience as R & D medicinal chemist in advancing projects from inception to Phase I clinical trials in ocular, inflammation, diabetes and neuroscience areas. Skilled in medicinal chemistry, organic chemistry, small molecule and peptide lead…
Clinical Development, Regulatory Development
Following more than 25 years in the pharmaceutical industry (Big Pharma, Contract Research Organizations, Small Pharma), Expert has accumulated experience from several hundred clinical studies, primarily in Phase I/Phase II ("First-in-Human", "proof-of-concept") across most therapeutic areas (Metabolic, Infectious, Oncology, Urology,…
Medicinal Chemistry, Synthetic Organic Chemistry, Drug Discovery, Pharmacokinetics
Expert has strong knowledge in asymmetric multi-step organic synthesis, scaffold design and library development with ability to solve challenging chemistry problems and have authored peer-reviewed articles and patents. Expert is a synthetic and medicinal chemist with over 13 years of…
Chemical Biology, Medicinal Chemistry, Drug Discovery, Cancer Pharmacology, Hypoxia
A major aspect of Expert's research is focused on how to circumvent or exploit resistance mechanisms by the development of tumour-selective agents targeting abnormal enzymatic expression in cancer tissues. He has had a long-standing interest in certain heterocyclic aromatic pharmacophores…
Chemical and Pharmaceutical Development – Comprehensive CMC
Expert has worked on research, development and manufacturing problems involving stereochemistry throughout his academic training and industrial career. Relevant examples include: development of scalable chiral and asymmetric syntheses; improvement of reaction stereoselectivity; tracking of chiral integrity in chemical processes; chiral…
Pharmaceutical Development, strategy planning and execution
Expert graduated in Biology at the University of Utrecht, The Netherlands, in 1984. From 1985-89 he was a PhD student at the University of Basel. The research in the field of gene regulation was carried out at the Friedrich Miescher…
Pharmaceuticals, Biotechnology, Clinical Pharmacology, Pharmacokinetics, Clinical Trials
Expert is an expert in drug discovery and development years of experience in clinical pharmacology, pharmacokinetics and clinical trials of pharmaceuticals. Trained in medicinal chemistry, Expert undertook clinical pharmacology research in a University Hospital for 12 years before joining the…
Pharma/Biotech Development, Life-Cycle Management, 505(b)(2), Chemical Development, CRO Services
Expert is a Pharmaceutical development leader with ~25 years drug development and manufacturing experience with large Pharma, large Biotech, and a highly successful small start-up. Managed large groups (from three different countries), teams and budgets. Played critical roles in several…
Molecular Pathology and Novel Solutions to Thrombosis, Cancer, Sepsis, Immunopathology.
Expert has pioneered the identification of the proteins of the Coagulation cascade responsible for Thrombosis, Hemostasis, Disseminated Intravascular Coagulation, Sepsis, Inflammation and the roles in neoplastic cell invasion and metastasis. He was the first to successfully identify and isolate Factor…