Expert Details

Expert in Analytical Chemistry: HPLC, LC-MS, Bioanalysis. R&D projectmanagement; writing of publications

Expert ID: 729685 Netherlands

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Expert’s scientific expertise includes the development, optimization and validation of quantitative bioanalytical methods for small molecules, peptides and biopharmaceutical drugs as well as for their metabolites in biological fluids (plasma, urine, tissue, etc.). These methods are essential for the pharma industry to generate the necessary (pre)clinical toxicokinetic (TK), pharmacokinetic (PK), bioavailability, and metabolic id/stability data. He also developed several analytical (metabolomics) tools for the discovery of biomarkers and bioactive compounds. During his career Expert has successfully set up R&D laboratory facilities and run innovative research projects. Next to managing these laboratories and research projects he has been responsible for raising the necessary funds.
In addition, Expert has demonstrated to be able to acquaint himself rapidly with other fields of expertise. This is illustrated by the research projects he initiated.


Development of bioanalytical LC-MS methods for miRNA mimics.
Expert did, for a small biotech company, a consultancy job to develop and apply of bioanalytical LC-MS methods to determine miRNA mimics in biological fluids and tissues.Total carbohydrate analysis (Tocana),
Expert did coordinate for a major Food Company in Europe the development of a generic screening method to fully identify all the components in an complex carbohydrate mixture (GOS, FOS, human milk).
Ref Coulier L, Timmermans J, Bas R, Van den Dool R, Haaksman I, Klarenbeek B, Slaghek T, Expert WD, J. Agric. Food Chem. 2009, 57, 8488–8495I set up more than 50 bioanalytical methods for pharmaceutical companies.

Education

Year Degree Subject Institution
Year: 1996 Degree: PhD Subject: Bioanalytical Chemistry Institution: Utrecht University
Year: 1993 Degree: MSc Subject: Analytical Chemistry Institution: Free University Amsterdam

Work History

Years Employer Title Department Responsibilities
Years: 2011 to Present Employer: Undisclosed Title: Innovation Manager Department: Analytical Chemistry Pharma Responsibilities: Responsible for scientific development and commercialization of small molecule, peptide and biopharmaceutical analysis using ligand binding assays and LC-MS. Also for setting up assays for wanted and unwanted immunogenic response to biopharmaceutical compounds.
Years: 2010 to 2011 Employer: Proxy Laboratories Title: Manager Analytical R&D Department: Analytical R&D Responsibilities: Setting-up and operationalized this GMP/GLP mass spectrometry & LC-MS facility for PROSENSA/PROXY.
Main activities: (bio)pharmaceutical analysis. Development and validation of pharmaceutical analytical methods for biopharmaceuticals: main focus: therapeutic oligonucleotides.
Years: 2005 to 2010 Employer: TNO Quality of Life Title: Product Manager Analytical Research Department: Analytical Research Responsibilities: Main activities: development and application of analytical/discovery tools for bioactive compounds (functional ingredients, flavors and fragrances), metabolomics and analytical platforms for Food/Feed Safety Screen.
Years: 2002 to 2005 Employer: Synthon BV Title: Head Analytical R&D Department: Analytical R&D Responsibilities: Responsibilities: Analytical Research Support of Active Pharmaceutical Ingredient (API) and Drug Product (DP); Development/validation of methods for pharmaceutical QC analysis. Accomplishments: Improved the throughput, flexibility and quality of the department and implemented new technology such as LC-MS.
Years: 1998 to 2002 Employer: TNO Pharma Zeist Title: Product Manager Bioanalysis Department: Bioanalysis Responsibilities: Responsibilities: Study Director/projectmanager Bioanalysis according to GLP
Development and validation of bioanalytical methods (mainly LC-MS)
Accomplishments: Optimization of the method development process and sample throughput by setting up automated on-line sample preparation procedures (Prospekt/Turboflow).
Acquisition of many external projects (UK, France, USA, etc.).

Years: 1996 to 1998 Employer: Pharma Bio-Research Assen Title: Study Director/Research Chemist Department: Laboratory for Bioanalysis Responsibilities: Responsibilities: Study Director/projectmanager Bioanalysis according to GLP
Development of bioanalytical methods (mainly LC-MS, LC-UV). Acquisition of bio-analytical projects

Government Experience

Years Agency Role Description
Years: 2012 to 2013 Agency: Hoge School Leiden Role: Auditor of Scientific Quality Description: Scientific Internal Audit of Analytical Chemistry Bachelor Education

Career Accomplishments

Associations / Societies
Mensa, the high IQ society (member number NL6638); Dutch Society of Mass Spectrometry (NVMS); American Society of Mass Spectrometry (ASMS).
Awards / Recognition



European Bioanalytical Forum Poster prize; EBF Barcelona; November 2012

TNO PEARL 2007 for most innovative project 2006:For Quality Mapping Project

NVMS travel grant for IMSC Budapest 1994
Dutch Society of Mass Spectrometry; October 1994; Travel grant to present my poster: "The diagnostic value of m/z 102 in high energy CID tandem mass spectra of singly protonated peptides"
Publications and Patents Summary
He is (co-)author of more than 30 peer reviewed scientific publications.

Additional Experience

Expert Witness Experience
He litigated several times to support analytical chemistry data in court (The Netherlands).
Vendor Selection
Expert has purchased, during his career 7 mass spectrometers (LC-MS systems), ranging from 200000-500000 Euros, from different vendor's. He selection the optimal instrument based on demo data. Expert also purchased several other instruments (HPLC, GC equipment).
Marketing Experience
Expert’s scientific expertise includes the development, optimization and validation of quantitative bioanalytical methods for small molecules, peptides and biopharmaceutical drugs as well as for their metabolites in biological fluids (plasma, urine, tissue, etc.). These methods are essential for the pharma industry to generate the necessary (pre)clinical toxicokinetic (TK), pharmacokinetic (PK), bioavailability, and metabolic id/stability data. He also developed several analytical (metabolomics) tools for the discovery of biomarkers and bioactive compounds. During his career Expert has successfully set up R&D laboratory facilities and run innovative research projects. Next to managing these laboratories and research projects he has been responsible for raising the necessary funds.
In addition, Expert has demonstrated to be able to acquaint himself rapidly with other fields of expertise. This is illustrated by the research projects he initiated.
Other Relevant Experience
He is an expert in GLP and GMP. He is able to write scientific reports: organize&report complex scientific data and draw conclusions from them. He is capable of writing scientific publications. He knows to set-up R&D laboratories.

Language Skills

Language Proficiency
Dutch native
English He is working on a daily basis with English speaking clients. He reads a lot of scientific literature in English and he writes scientific articles.

Fields of Expertise

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