Expert in Cancer to Cardiovascular Research, Cardiovascular Biology, Tumor Biology, Technologies related to Cardiovascular Biology (research), Molecular Biology, Molecular Physiology
Expert ID: 736050 Texas, USA
Over the course of his academic training and career, Expert has acquired the ability to work across a diverse spectrum of research teams, both nationally and internationally, formulate data driven hypotheses to solve complex translational research problems and communicate the research findings in high impact publications. During his research career, Expert has gained an expertise in working with different disease models ranging from cancer, muscle, cardiovascular and metabolic diseases. He has also acquired significant experience in working with cutting edge research technologies such as high throughput sequencing, iPSCs and other stem cell technologies to identify molecular pathways in human patients of muscle and cardiac disease such as Duchenne Muscular Dystrophy.
Expert has more than 18 years of research experience across a wide variety of biomedical research models and has collaborated with world renowned experts in the field of cancer, cardiovascular disease, and metabolism.
Expert may consult nationally and internationally, and is also local to the following cities: Fort Worth, TX - Dallas, TX - San Antonio, TX - Oklahoma City, OK - Austin, TX - Houston, TX
|Year: 2020||Degree: MBA||Subject: Healthcare management||Institution: University of Texas at Dallas|
|Year: 2013||Degree: Diploma in Advanced Research (Postdoctoral Fellowship)||Subject: Molecular Cardiology||Institution: University of Texas Southwestern Medical Center|
|Year: 2008||Degree: PhD||Subject: Cellular and Molecular Biology||Institution: Centre for Cellular and Molecular Biology|
|Year: 2000||Degree: MS||Subject: Biochemistry||Institution: Hamdard University|
|Year: 1998||Degree: BS||Subject: Biochemistry||Institution: University of Delhi|
|Years: 2019 to Present||Employer: Undisclosed||Title: Instrcutor||Department: School of LIfe Sciences||Responsibilities: Designing and administering course curriculum for undergraduate students. Classroom teaching with hands on laboratory exercises, designing and administering tests and exams in accordance with the university policy.|
|Years: 2013 to 2018||Employer: University of Texas Southwestern Medical Center||Title: Instructor||Department: Internal Medicine/Cardiology||Responsibilities: As a faculty in the cardiology division of University of Texas Southwestern Medical Center at Dallas, I was engaged in performing cutting edge research to discover novel pathways involved in the progression of heart and muscle disease. The job responsibilities in this role included identifying high impact research question followed by designing and executing hypothesis driven research projects while leading a team of supporting research scientists, grant writing to secure research funding and research presentations at national and international meetings. In addition, I was involved in providing scientific training and intellectual feedback to senior research scientists, clinical research fellows and medical students in their respective projects. I was also responsible for managing research grant budget and ensuring research compliance for the projects under my supervision.|
|Associations / Societies|
|Dates, Society Name, member
2007-present American Heart Association
2011-present American Association for Advancement of Science
2012-present Sigma Xi
2018-present American College of Healthcare Executives
|Year(s) Academic Title Department Academic Institution
2013-2015 Asst. Instructor Internal Medicine/
Cardiology UT Southwestern Medical Center; Dallas, TX
2015-2018 Instructor Internal Medicine/
Cardiology UT Southwestern Medical Center; Dallas, TX
2018-present Adjunct Instructor Internal Medicine/
Cardiology UT Southwestern Medical Center; Dallas, TX
2019-present Adjunct Instructor Biology/School of Arts and Sciences University of North Texas at Dallas; TX
|Awards / Recognition|
|Year Name of Honor/Award Awarding Organization
2nd Place in the Annual Biochemistry Quiz. Delhi University; New Delhi, India Delhi University
National Eligibility Test Scholarship, (Pre-doctoral Fellowship) Council of Scientific and Industrial Research (CSIR), India
Best Poster Presentation at the Annual CCMB Open Day Centre for Cellular and Molecular Biology (CCMB); Hyderabad, India
International Travel award Cold Spring Harbor Laboratory
International Travel Grant Award CSIR and Department of Biotechnology (Government of India)
South Central Postdoctoral Fellowship Award American Heart Association
Young Investigator Travel Award American Heart Association
Finalist: The Louis N. and Arnold M. Katz Basic Science Research Award American Heart Association
Competitive Scholarship for the Full Time MBA Cohort University Of Texas at Dallas
3rd Place at the 10th International Emory Global Health Case Competition Emory University
Colloquium for Advancement of Free Enterprise (CAFÉ) Graduate Fellowship University Of Texas at Dallas
|Medical / Professional|
|Year(s) Name of Committee Institution/Organization
2018-19 Leader of the Graduate Dean’s Council at University of Texas at Dallas University Of Texas at Dallas
2007 Judging committee for the UTSW Postdoctoral travel award and Women in Science travel award UTSW Postdoctoral Association
1996-1998 Organizing committee for the Annual Biochaperone inter college event Delhi University; New Delhi, India
2004 Organizing and proceedings committee for the International European Molecular Biology Organization (EMBO) workshop on Cell Interaction in Development and Disease European Molecular Biology Organization (EMBO) and Centre for Cellular and Molecular Biology (CCMB)
2005 Organizing committee for the 1st Annual International Conference on Translational Research for Cancer and other Diseases New York Medical College and CCMB
|Publications and Patents Summary|
|1. The focus of my early research was on investigating the molecular mechanisms of apoptosis or programmed cell death. Several of the publications from my PhD research (2001-2006) addressed the molecular underpinnings of the mitochondrial apoptotic pathway in tumor cells. In 2001, apoptosis was a newly discovered pathway and the studies describing the mechanistic details of intracellular processes within an apoptotic cell were limited. My studies targeted at identifying differential gene expression in apoptotic cells led to the discovery of several novel genes that were shown to be critical in the execution of apoptosis. Specifically, I discovered that several subunits of the mitochondrial F0-F1 ATP synthase complex were upregulated during the early phases of apoptosis, resulting in increased ATP generation. In addition, I also identified a novel pro apoptotic role for the ubiquitin-proteasome machinery mediated by induction of the proteasome subunits’ gene expression. This body of work described, for the first time, several novel intracellular processes that are employed by the cell to successfully execute the apoptotic pathway. These studies discovered new distinguishing features of programmed cell death and shed new light on how the changes in gene expression are transformed into physiological events during apoptosis. I led majority of these studies in my capacity as the primary investigator or a co-investigator.
2. Cardiac remodeling in response to acute or chronic pathological stress is a complex and generally irreversible process. The genome wide expression changes and the resulting cross talk between molecular signaling components make it a challenge to identify new pathways that could be targeted to modulate left ventricular remodeling and subsequently modulate heart failure. My postdoctoral research focused on understanding the role of tissue globins (Cytoglobin and Myoglobin) in models of cardiac disease established the role of hypoxia and key regulatory factors in the transcriptional regulation of tissue globins. I also discovered novel roles of redox signaling in the regulation of cardiac hypertrophy via p53 modulation. These studies identified novel regulatory mechanisms governing cardiac remodeling during pathological or physiological hypertrophy and provided new targets for potential therapeutic intervention. I served as the primary investigator on these studies.
3. Skeletal myogenesis following acute muscle injury involves activation of myogenic progenitor cells (MPC) that contribute to the repair of injured muscle fibers by generating new myofibers and MPC self- renewal. The myogenic process is associated with oxidative stress but the redox factors and stress signals involved in regulating myogenesis following injury are not very well understood. As I transitioned to a junior faculty position, my research focused on investigating molecular mechanisms underlying skeletal muscle regeneration. I discovered a new redox sensitive protein that is critical for MPC viability and subsequent muscle regeneration in response to injury and reported its specific role in myoblast survival, proliferation and differentiation. These findings enhance our overall understanding of myogenesis and provide new information about the role of oxidative stress in muscle regeneration, which may enable the development of therapeutic approaches for treating patients with muscle injuries and other neuromuscular disorders. I served as the primary investigator on these studies.
|Training / Seminars|
2010 Cytoglobin regulates myocyte proliferation and differentiation by homeostatic and stress induced repression of p53 transcriptional activity American heart Association Scientific Sessions 2010, Chicago
2013 Cytoglobin: A Novel Epicardial Regulator of Epithelial to Mesenchymal Transition (EMT) within the Ischemic Heart American heart Association Scientific Sessions 2013, Dallas
2015 Identifying novel modulators of muscle regeneration in the mammalian heart Centre for Cellular and Molecular Biology, Hyderabad, India
Teaching and Training Activities
Undergraduate Level University Teaching
2020 Instructor for the BIOLOGY 1740 Science Major Lab II course at University of North Texas at Dallas (Two Sections)
2019 Instructor for the BIOLOGY 1730 Science Major Lab I course at University of North Texas at Dallas (Four Sections)
Medical and graduate school didactic and small group teaching
2014 Instructor in “Introduction to Research” course for Medical Student search Research Program (MSRP) at UTSW
Medical student rotations
2009; Adrian Salinas (UTSW Medical School) Oversight and training in cellular biology techniques and genetically modified mouse models of cardiovascular biology and disease.
2009; Bryan Reyes (UTSW Medical School) Oversight and training in basic molecular biology techniques and genetically modified mouse models of cardiovascular biology and disease.
2010; Anita Kallepalli (UTSW Medical School) Training in cellular morphometric analysis
2015; Magid Mohamed
(UTSW Medical School) Training in Myogenic Progenitor Cell isolation, transcriptional and gene expression assays.
Undergraduate student trainees
2009; Sudhir Thotakura (Texas Tech University Health Science Center) Training in basics of molecular biology and cellular morphometric analysis
2010; Melanie Weiler (UT Austin) Advance Training in molecular biology techniques and genetically modified mouse models of muscle regeneration and disease.
2012; Christina Collier (Physician Scientist Training Program) Overview of basic techniques with focus on understanding of mouse models of disease.
Graduate student trainees
2010-11; Shandon Collins (Lab technician and Medical School Applicant) Taught nucleic acid biology and experimental procedures. Oversight in experiment planning, design and execution. Advance training in molecular biology techniques
2013-16; Dylan Rivas
(Lab technician) Training in routine molecular biology techniques with focus on data analysis and troubleshooting.
2016-present; Tara Tassin
(Research Scientist) Advisor in models of cardiovascular disease, data collection, analyses and troubleshooting.
Postgraduate medical education (graduate & continuing medical education)
2012-14; Kasey Leger, MD (Pediatric Hematology & Oncology Fellow, UTSW) Training in basic molecular biology techniques with focus on micro RNA biology. Guidance with sample preparation, experimental design and troubleshooting.
2013-14; David Sutcliffe, MD (Pediatric Cardiology Fellow, UTSW) Advisor in experimental design, data analysis and troubleshooting.
2015-16; Chris French, MD (Cardiology Fellow, UTSW) Advisor in experimental design, data analysis and troubleshooting
2009-13; Diana Canseco (Postdoctoral Fellow, Mammen Lab, UTSW) Training in molecular and cellular biology techniques. Training in cell culture and in vitro assays. Continued support with experiment design and troubleshooting
2014; Krithika Selvarajan (Postdoctoral Fellow, Mammen Lab, UTSW) Training in specialized cell isolation techniques and advanced molecular biology techniques.
|Other Relevant Experience|
|Consulted for a Texas law firm for a MDL on the use of Zantac and elevated risk of cancer. It was a 70 hour project that involved exhaustive literature search and analyses on the possible metabolic conversion of Ranitidine (active ingredient in Zantac) into NDMA, a known probable carcinogen. A report was prepared and delivered to the client followed by a short in person presentation.|
Fields of Expertise
appendiceal cancer, acute myocardial infarction, cardiomyopathies, cardiology, cardiopulmonary disease, cardiovascular abnormality, cardiovascular disease, cardiovascular research, cardiovascular drug therapy, cardiovascular pharmacology, cardiovascular system, antitumor drug, tumorigen, cancerous tumor, central nervous system tumor, brain tumor, gastrointestinal stromal tumor, lung tumor, tumor, tumor biology, tumor marker testing, tumor necrosis factor, tumor pathology, Duchenne muscular dystrophy, skeletal muscle physiology, musculoskeletal disease, muscular dystrophy, muscular disease, neuromuscular disorder, adverse drug effect, adverse drug reaction, antagonistic drug, anti-fibrotic drug, animal molecular biology, applied molecular biology, biologic (product), biological cell development, biological cell differentiation, biological drug level, apoptosis, cellular signal transduction, biomedical signal processing, cancer biology, cancer causation, cancer chemotherapeutic agent, breast cancer, cancer, cancer cytology, cancer immunotherapy, cancer research, cancer chemoprevention, cancer immunology, cancer pathology, cancer treatment, cancer physiology