Mitochondrial DNA Stability, Oxidative Stress, Metabolism
ID: 731532
Pennsylvania, USA
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Expert is an Assistant Professor at Employer studying mechanisms that regulate mitochondrial DNA stability, which is of broad medical relevance, including aging, diabetes, liver disease, heart disease, and cancer. Expert's laboratory has published in Nucleic Acids Research, Nature Cell Biology, and Pos ONE. During Ph.D. research, Expert performed the seminal characterization of proteins involved in mitochondrial DNA metabolism, which was published in Proceedings of the National Academy of Science, Science, Journal of Cell Biology, and Methods in Molecular Biology. He went on to work with Dr. Eric Shoubridge at McGill University, where he discovered the primary mechanisms of compaction and organization of mammalian mtDNA and contributed to the study of understanding respiratory disorder etiology, publishing in Molecular Biology of the Cell, Cell Metabolism, and Human Molecular Genetics, and Nature Genetics. In total, he has over 17 years experience in working with mitochondria and mtDNA interacting proteins. He is active in the Mitochondrial Research Affinity Group and Center for Mitochondrial and Epigenomic Medicine at UPENN.
He has provided feedback on therapeutic opportunities in mitochondria regarding potential drug targets