Expert in Molecular Biology, Genetics, Cancer Biology, Radiation Biology, Genetic Engineering
Expert ID: 731251
Expert has been continuously funded by the NIH (NCI, NIGMS), typically as PI of 2-3 concurrent R01 grants, and published >100 reports of original research and reviews that have been cited >4500 times (h index = 32). Publications have appeared in top journals including Nature, Nature Structural and Molecular Biology, Molecular Cell, PNAS, Blood, Cancer Research, Molecular and Cellular Biology, Oncogene, Nucleic Acids Research, and Genetics. He served for 8 years as Chair of the Department of Molecular Genetics and Microbiology in the University of New Mexico School of Medicine, a department with 16-18 faculty and a $6M annual budget. He was Director/co-Director of the UNM Cancer Center Cancer Biology program and in this role helped secure both P20 and P30 Cancer Center support grants. Expert has led the CSU Department of Environmental and Radiological Health Sciences, with 40-42 faculty, and a $13M annual budget. Expert holds a patent (Site-Directed Mutagenesis of DNA) that was licensed by three biotechnology companies. Expert has >30 years of experience in genetic engineering, and >25 years of experience in the fields of eukaryotic DNA repair, cell signaling responses to DNA damage including replication stress responses. He is a leader in the field of chromatin regulation of DNA repair. His latest NIH grant focuses on molecular mechanisms of cell response to chemotherapeutic agents, largely using molecular genetic approaches. He has served on numerous NIH grant review panels and grant review panels for foreign funding agencies. He is currently leading studies of the biological effects of heavy ion (carbon) radiation at the Japan National Institute of Radiological Sciences in his role as Distinguished Foreign Scientist, and is also leading efforts to transfer US patients to Japan for carbon ion radiotherapy, building a consortium involving CSU, the University of Colorado Denver School of Medicine and Cancer Center, Children's Hospital to establish a carbon ion radiation facility and a set of integrated research, training, and clinical programs built on existing strengths of the partner institutions, and focused on a state-of-the-art carbon ion radiation facility on the UC Denver Medical Campus. The unique strengths of this partnership will allow us to build a carbon ion radiotherapy program like no other in existence or planned anywhere in the world. These strengths include: world-class human and animal cancer centers with leading radiotherapy programs; world-class pediatric cancer care at Children's Hospital; top-rated, long-standing basic, translational, and clinical research and educational programs in radiobiology, radiation physics, medical physics, and radiation oncology; outstanding human and animal diagnostic radiology programs (essential for tumor imaging and accurate tumor targeting); and importantly, full integration of the NIRS radiation oncologists and medical physicists to provide patients treated at the Colorado Facility with nearly 20 years of clinical experience.
He consulted with the law firm Piper Rudnick LLP, Washington, DC on a biotechnology patent law dispute. He has served as Science Advisory Board member, KromaTid, Inc. KromaTid is a start up biotechnology firm that manufactures molecular cytogenetic and custom gene tracking assays to discover, detect and diagnose the widest range of disease causing mutations – including inversions and translocations – in a single test. Based on Directional Genomic Hybridization™ (dGH), KromaTiD assays generate sequence, location and orientation data from single cells, making them ideal for mixed cell population studies.He is a member of the Scientific Advisory Board for Colorado State University/University of Texas Medical Branch NASA Specialized Center of Research program. This NASA funded program is focused on molecular genetic studies of cancer induced by space radiation.
Expert may consult nationally and internationally, and is also local to the following cities:
Denver, Colorado - Aurora, Colorado - Fort Collins, Colorado - Arvada, Colorado - Westminster, Colorado - Boulder, Colorado - Greeley, Colorado - Longmont, Colorado - Loveland, Colorado - Cheyenne, Wyoming