Expert Details

Expert in Molecular Biology, Genetics, Cancer Biology, Radiation Biology, Genetic Engineering

Expert ID: 731251 Colorado, USA

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Expert has been continuously funded by the NIH (NCI, NIGMS), typically as PI of 2-3 concurrent R01 grants, and published >100 reports of original research and reviews that have been cited >4500 times (h index = 32). Publications have appeared in top journals including Nature, Nature Structural and Molecular Biology, Molecular Cell, PNAS, Blood, Cancer Research, Molecular and Cellular Biology, Oncogene, Nucleic Acids Research, and Genetics. He served for 8 years as Chair of the Department of Molecular Genetics and Microbiology in the University of New Mexico School of Medicine, a department with 16-18 faculty and a $6M annual budget. He was Director/co-Director of the UNM Cancer Center Cancer Biology program and in this role helped secure both P20 and P30 Cancer Center support grants. Expert has led the CSU Department of Environmental and Radiological Health Sciences, with 40-42 faculty, and a $13M annual budget. Expert holds a patent (Site-Directed Mutagenesis of DNA) that was licensed by three biotechnology companies. Expert has >30 years of experience in genetic engineering, and >25 years of experience in the fields of eukaryotic DNA repair, cell signaling responses to DNA damage including replication stress responses. He is a leader in the field of chromatin regulation of DNA repair. His latest NIH grant focuses on molecular mechanisms of cell response to chemotherapeutic agents, largely using molecular genetic approaches. He has served on numerous NIH grant review panels and grant review panels for foreign funding agencies. He is currently leading studies of the biological effects of heavy ion (carbon) radiation at the Japan National Institute of Radiological Sciences in his role as Distinguished Foreign Scientist, and is also leading efforts to transfer US patients to Japan for carbon ion radiotherapy, building a consortium involving CSU, the University of Colorado Denver School of Medicine and Cancer Center, Children's Hospital to establish a carbon ion radiation facility and a set of integrated research, training, and clinical programs built on existing strengths of the partner institutions, and focused on a state-of-the-art carbon ion radiation facility on the UC Denver Medical Campus. The unique strengths of this partnership will allow us to build a carbon ion radiotherapy program like no other in existence or planned anywhere in the world. These strengths include: world-class human and animal cancer centers with leading radiotherapy programs; world-class pediatric cancer care at Children's Hospital; top-rated, long-standing basic, translational, and clinical research and educational programs in radiobiology, radiation physics, medical physics, and radiation oncology; outstanding human and animal diagnostic radiology programs (essential for tumor imaging and accurate tumor targeting); and importantly, full integration of the NIRS radiation oncologists and medical physicists to provide patients treated at the Colorado Facility with nearly 20 years of clinical experience.

He consulted with the law firm Piper Rudnick LLP, Washington, DC on a biotechnology patent law dispute. He has served as Science Advisory Board member, KromaTid, Inc. KromaTid is a start up biotechnology firm that manufactures molecular cytogenetic and custom gene tracking assays to discover, detect and diagnose the widest range of disease causing mutations – including inversions and translocations – in a single test. Based on Directional Genomic Hybridization™ (dGH), KromaTiD assays generate sequence, location and orientation data from single cells, making them ideal for mixed cell population studies.He is a member of the Scientific Advisory Board for Colorado State University/University of Texas Medical Branch NASA Specialized Center of Research program. This NASA funded program is focused on molecular genetic studies of cancer induced by space radiation.

Expert may consult nationally and internationally, and is also local to the following cities: Denver, Colorado - Aurora, Colorado - Fort Collins, Colorado - Arvada, Colorado - Westminster, Colorado - Boulder, Colorado - Greeley, Colorado - Longmont, Colorado - Loveland, Colorado - Cheyenne, Wyoming

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Education

Year Degree Subject Institution
Year: 1983 Degree: PhD Subject: Biochemistry Institution: University of Colorado, Boulder
Year: 1978 Degree: BA Subject: Biochemistry Institution: University of California Santa Barbara

Work History

Years Employer Title Department Responsibilities
Years: 2008 to Present Employer: Undisclosed Title: Professor and Department Head Department: Environmental and Radiological Health Sciences Responsibilities: He manages a diverse faculty in six sections (Radiation Cancer Biology and Oncology, Radiology, Health Physics, Toxicology, Environmental Health Epidemiology, Industrial Hygiene). He oversees clinical (veterinary) radiology and radiation oncology programs, bachelors, masters, and doctoral degree programs, and an NIH-funded research lab with 6-8 members.
Years: 1996 to 2008 Employer: University of Colorado School of Medicine Title: Assoc Professor/Professor/Chair Department: Department of Molecular Genetics and Microbiology Responsibilities:

Government Experience

Years Agency Role Description
Years: 1993 to Present Agency: NIH Role: Study section member Description: He is responsible for reviewing R01 and P01 grant applications for the National Cancer Institute and the National Institute of General Medical Sciences
Years: 1987 to 1990 Agency: Los Alamos National Laboratory Role: Postdoctoral fellow Description: He performed molecular genetic and radiobiology research focused on DNA repair mechanisms and cancer.

International Experience

Years Country / Region Summary
Years: 2008 to Present Country / Region: Japan Summary: He is leading an effort to link basic scientists, translational scientists, veterinarians, and physicians at Colorado State University, the University of Colorado School of Medicine, and the Japan National Institute of Radiological Sciences. The goal of this project is to construct a novel cancer research and treatment facility in Colorado, in collaboration with the NIRS, focused on carbon and other heavy ion radiation therapy. Related projects include the development of joint US-Japan graduate training programs in radiobiology, medical physics, and radiation oncology, and a program to transfer US cancer patients to Japan for carbon ion radiotherapy at the NIRS facility. He travels to Japan 3-4 times per year and he organizes an annual conference in Colorado to promote these projects.
Years: 2013 to Present Country / Region: Mexico Summary: He is leading a team of environmental health scientists from Colorado State University in the development of projects in Todos Santos, Baja California Sur, Mexico. Projects under consideration include efficient waste disposal/waste-to-energy generation, water use and water safety, and agricultural safety (pesticides, etc).

Career Accomplishments

Associations / Societies
Genetics Society of America, American Association for Cancer Research, Radiation Research Soceity
Professional Appointments
Associate Editor, Genetics, Associate Editor, Molecular Biotechnology, Editorial Board, ISRN Genetics.

Publications and Patents Summary
Published >100 original articles, >20 review articles in DNA repair, cell biology and cancer biology fields, has one patent, edited or co-edited 6 volumes (3 on DNA damage and repair, 3 technical manuals).

Additional Experience

Expert Witness Experience
Expert witness in biotechnology patent case (gene therapy). Deposition filed with Piper Rudnick LLP, Washington, DC.
Training / Seminars
Presented 34 invited seminars at professional meetings, Organized three international symposia focused on radiation oncology (basic and translational science, and clinical practice). Organized sessions at 6 international scientific conferences.
Vendor Selection
Directed NIH funded research laboratory typically funded by 2-3 R01 grants. Led basic science department at Univ of New Mexico School of Medicine: $6M annual budget. Leading 40+ faculty member department with basic, applied, and clinical (veterinary) sections: $13M annual budget.
Marketing Experience
Lead on patent licensed by 3 biotechnology companies. Developed research collaborations with biotech/pharmaceutical industry partners. Currently developing program with Japan National Institute of Radiological Sciences to transfer US cancer patients for novel radiotherapy in Japan - this project also involves Japanese insurance industry partners and partners at the University of Colorado Health Systems (University of Colorado School of Medicine and Poudre Valley Health System in Fort Collins, CO).
Other Relevant Experience
20+ years of teaching experience in molecular genetics, cancer biology, biotechnology. Broad knowledge base due to PhD in plant genetics, postdoctoral experience in yeast molecular genetics and mammalian cell molecular genetics, and experience on the the faculty at Harvard University (7 years), UNM School of Medicine (12 years, 8 as department chair), and Colorado State University College of Veterinary Medicine and Biomedical Sciences (5+ years as department head). Directed/co-Directed Cancer Biology program for NCI-designated Cancer Center (UNM) and currently a member of University of Colorado Cancer Center, and CSU Flint Animal Cancer Center.

Fields of Expertise

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