Expert Details

Expert in Organic Chemistry, Analytical Chemistry, Biochemistry, Cell Biology, Photochemistry, Chromatography

Expert ID: 730236 New York, USA

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Extensive experience in the identification of macromolecular interactions by site-directed photosensitized reactions. Monospecific antibodies and other protein ligands conjugated to visible light photosensitizers are powerful tools to demonstrate whether macromolecules and/or cellular organelles interact in situ and in vitro. Using this site-directed approach the expert has shown that DNA repair enzymes bind microtubules and explored the photodynamic therapeutic potential of antibody-porphyrin conjugates.

Extensive experience in developing immunoassays and in raising and screening polyclonal and monoclonal antibodies. Antibody production has included antibodies raised against proteins and low molecular mass molecules (less than 0.5 kD). Extensive experience in customization of immunoassays, including enzyme linked immunosorbent assays (ELISA), immunoblotting (Western blots), immunoprecipitations, and affinity column chromatography. Using these approaches the expert has been able to detect in vitro and in situ the DNA lesion, 8-oxoguanine.

Extensive experience in the identification of molecular targets for naturally occurring toxins through combinations of mass spectral and proteomic analyses. Using LC/MS/MS the expert has been able to detect and quantitate DNA damage, as well as alterations in metabolic pathways, in small mammals exposed to toxins. In addition, she has developed assays by which immobilized toxin is used to pull down potential protein targets in tissue homogenates. Identification of protein targets is performed by combining biochemical, immunochemical and proteomic analyses. The expert also has detected and quantitated toxins from animal isolates and dietary supplements.

Expert may consult nationally and internationally, and is also local to the following cities: New York, New York - Yonkers, New York - Bridgeport, Connecticut - New Haven, Connecticut - Hartford, Connecticut - Newark, New Jersey - Jersey City, New Jersey - Paterson, New Jersey - Springfield, Massachusetts - Providence, Rhode Island

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Education

Year Degree Subject Institution
Year: 2001 Degree: Postdoctoral Subject: Cell Biology/Biochemistry Institution: SUNY at Stony Brook
Year: 1995 Degree: Ph.D. Subject: Organic Chemistry Institution: University of Connecticut
Year: 1992 Degree: M.S. Subject: Organic Chemistry Institution: University of Connecticut
Year: 1988 Degree: B.S. Subject: Chemistry Institution: University of Connecticut

Work History

Years Employer Title Department Responsibilities
Years: 2001 to 2011 Employer: SUNY at Stony Brook Title: Research Scientist Department: Pharmacology Responsibilities:
Years: 1998 to 2011 Employer: SUNY at Stony Brook Title: Research Instructor Department: Pharmacology Responsibilities:
Years: 1995 to 2001 Employer: SUNY at Stony Brook Title: Postdoctoral Research Associate Department: Pharmacology Responsibilities: Trained in cell biology/biochemistry.
Years: 1995 to 2001 Employer: Title: Department: Responsibilities:

Career Accomplishments

Associations / Societies
American Chemical Society,
American Society for Cell Biology.
Chemical Consultants Network
Publications and Patents Summary
The expert has published in peer reviewed journals and has four invention disclosures.

Fields of Expertise

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