Expert Details
Pharmaceutical Development, Design of Experiments
ID: 722849
Oregon, USA
the fine chemicals and pharmaceutical industry.
Expert has been involved for many years in developing chemical processes for the fine chemical and pharmaceutical industries.
Expert has used a wide variety of chemical process controls in the process of developing synthetic chemical reactions for the fine chemical and pharmaceutical industries.
Expert has been involved in developing processes in the fine chemicals and pharmaceutical industries for many years.
Expert has been working in the area of homogeneuos catalysis since completing his graduate studies with E. Negieshi at Purdue University.
Expert has a Ph.D. in organic chemistry and has been practicing synthetic organic chemistry on complex pharmaceutically active compounds for many years.
Expert has used design of experiments for developing models to understand complex chemical systems in the fine chemicals and pharmaceutical industries for many years.
Expert studied organometallic chemistry at Purdue University under E. Negishi
and has applied that knowledge to the fine chemicals and pharmaceutical
industries.
Education
| Year | Degree | Subject | Institution |
|---|---|---|---|
| Year: 1991 | Degree: Ph.D. | Subject: Chemistry | Institution: Purdue University |
| Year: 1985 | Degree: B.A. | Subject: Chemistry | Institution: Indiana State University |
Work History
| Years | Employer | Title | Department |
|---|---|---|---|
| Years: 2003 to Present | Employer: Undisclosed | Title: President | Department: |
Responsibilities:Expert is responsible for all areas of operation for a consulting and information services business: attracting and developing relationships with various potential clients; developing a business plan for operations of the company; and has provided reports and data for clients on various topics related to science, marketing, and competitive intelligence. |
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| Years | Employer | Title | Department |
| Years: 1998 to 2003 | Employer: Cell Therapeutics, Inc. | Title: Senior Staff Chemist | Department: |
Responsibilities:He was responsible for planning the development work for poly-glutamate polymer-paclitaxel conjugate (CT-2103) for four years. He participated and presented information for several due diligence potential partnerships. He was responsible for manufacturing campaigns under current Good Manufacturing Practice at various vendor sites, and for initial vendor audit and selection. He has extensive knowledge of the chemistry of paclitaxel. Expert was responsible for chemistry manufacturing and controls CT-2103 cross-functional group (analytical development, process development, formulation development, quality control, quality assurance, document control, active pharmaceutical ingredient manufacturing, finished product manufacturing). He was a core team member for CT-2103 (poly-glutamic acid paclitaxel polymer conjugate) on cross-functional team (regulatory, marketing, research, preclinical/toxicology, project management, clinical) representing manufacturing, and quality control. He was responsible for three years for multimillion-dollar budgets directly related to manufacturing and development; indirectly responsible for tens of millions of budget dollars and came within 3% of the budget, usually under budget. |
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| Years | Employer | Title | Department |
| Years: 1997 to 1998 | Employer: Synthetech | Title: Senior Process Development Chemist | Department: |
Responsibilities:Expert designed and refined synthetic schemes for the synthesis of specialty amino acids and peptide building blocks. He optimized and improved existing synthetic sequences. He executed synthetic schemes and clarified results both at bench scale as well as pilot plant scale. He analyzed and interpreted information to decide the further course of projects. He did troubleshooting of operations in the pilot plant when problems occurred. He has pilot plant experience (22-liter flasks and 50 to 500-gallon reactors). |
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| Years | Employer | Title | Department |
| Years: 1992 to 1997 | Employer: Bristol-Myers Squibb | Title: Research Scientist | Department: |
Responsibilities:He designed and refined synthetic schemes for the synthesis of key targets. He optimized and improved existing synthetic sequences for utilization in a kilo-lab. He executed synthetic schemes and clarified results. He analyzed and interpreted information to decide the further course of projects. |
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Career Accomplishments
| Associations / Societies |
|---|
| Expert is a member of the American Chemical Society, Parenteral Drug Association, and Association of Information Professionals. |
| Publications and Patents Summary |
|---|
| He has one patent application, eight technical journal articles, and several articles on information services. |
Additional Experience
| Training / Seminars |
|---|
| Expert teaches classes on design of experiments and critical thinking and decision making. |
| Vendor Selection |
|---|
| He has extensive experience in selecting contract manufacturers in the pharmaceutical and fine chemicals industries. |
Language Skills
| Language | Proficiency |
|---|---|
| German | Expert can read technical German from the older literature. |
Fields of Expertise
applied organic chemistry, chemical process monitoring, chemical process, chemical processing, organic compound process development, pharmaceutical chemistry, chemical process control, process technology, fine chemical, fine organic synthesis, homogeneous catalysis, organic chemistry, organic synthesis, synthetic organic chemistry, organic compound synthesis modeling, analysis of experiments, organometallic chemistry, organometallic compound, chiral synthesis, activated ester, combinatorial chemistry, chemical process design, dynamic process simulation, heterocyclic compound synthesis, natural product chemistry, fine chemical marketing, organic chemical separation, fine chemical production, coupling agent, catalyst structure optimization, exothermic chemical reaction control, chemical reactor control, enantioselective catalysis, chemical reaction engineering, reactor mixing, fine chemical intermediate, chemical intermediate, chemical process equipment, new chemical process operations, chemical process troubleshooting, organic reaction, chemical process development, chemical reactor model, chemical-process flow chart, chemical reaction, alkylation, carbanion, carbocation, chemical process safety, alcohol compound, organophosphorus chemistry, chemical reaction mechanism, pharmaceutical drug, organic reaction mechanism, organic compound, qualitative organic chemistry, organosilicon chemistry, organic chemical structure, hydrolysis, heterocyclic compound, chemical reactor scale-up, chemical reactor, chemical analysis, catalyst, carbocation chemistry, carbanion chemistry, amine, amide, aldehyde