Expert Details
Free and Antioxidant Radical Chemistry and Biology
ID: 107704
Iowa, USA
Expert has had considerable experience with biological oxidants and antioxidants. He has investigated the chemistry and biochemistry of both small molecule antioxidants, such as ascorbate and tocopherol, and antioxidant enzymes. His present research deals with the fundamental antioxidant chemistry of vitamins C and E (ascorbate and tocopherol). He is also working with thiols such as glutathione. He has experience with antioxidant enzymes such as catalase, glutathione peroxidase, and superoxide dismutase.
Expert has considerable experience in the study of various oxygen-centered free radicals such as superoxide, hydroxyl radical, and peroxyl free radicals. His research has dealt with the fundamental chemistry of these radical species. It has also dealt with how they interact to cause biological oxidations such as lipid peroxidation.
Expert has been a pioneer in the study of free radical chemistry of biologically related free radicals. He was at the forefront of the study of iron and chelating agents in this chemistry. He continues to be active in this area of research.
Expert has expertise in the photosensitized production of singlet oxygen and free radicals. These studies have involved promazine and chlorpromazine and riboflavin. They also include work on hematoporphyrin derivative, a photosensitizer being tested for the treatment of cancer. Expert has used EPR spin trapping as well as laser flash photolysis in these studies.
Expert has over 15 years of experience in research on cellular lipid peroxidation processes. He has developed new approaches to detect the free radicals associated with cellular lipid peroxidation. He has also investigated how ascorbate, tocopherol and nitric oxide interact to serve as cellular antioxidants.
Expert has developed new ways to detect and quantitate nitric oxide. A major current research focus is on the mechanisms by which nitric oxide serves as a cellular and tissue antioxidant.
Education
| Year | Degree | Subject | Institution |
|---|---|---|---|
| Year: 1976 | Degree: Ph.D. | Subject: Chemistry | Institution: The University of Iowa |
| Year: 1969 | Degree: M.S. | Subject: Chemistry | Institution: The University of Iowa |
| Year: 1967 | Degree: B.A. | Subject: Chemistry | Institution: University of Northern Iowa |
Work History
| Years | Employer | Title | Department |
|---|---|---|---|
| Years: 1988 to Present | Employer: Undisclosed | Title: Director and Professor | Department: College of Medicine/ESR Facility |
Responsibilities:Expert is a Professor in the Free Radical and Radiation Biology Graduate Program. He directs the Electron Spin Resonance Core Facility, and conducts research on the role of free radicals and antioxidants in health and disease. |
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| Years | Employer | Title | Department |
| Years: 1988 to 1988 | Employer: National Institutes of Health/NIEHS | Title: Senior Expert | Department: Laboratory Molecular Biophysics |
Responsibilities:He performed research on the fundamental chemical biology of free radicals and antixoidants. |
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| Years | Employer | Title | Department |
| Years: 1985 to 1987 | Employer: GSF Research Institute, Germany | Title: Fulbright Fellow/Guest Scientist | Department: Institute for Radiation Biology |
Responsibilities:Expert was a Fulbright Scholar and visiting scientist, conducting research on the kinetics of free radical reactions. |
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| Years | Employer | Title | Department |
| Years: 1984 to 1985 | Employer: NIH/NIEHS | Title: Senior Expert | Department: Laboratory Molecular Biophysics |
Responsibilities:He conducted research on the fundamental chemical biology of free radicals and antixoidants. |
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| Years | Employer | Title | Department |
| Years: 1978 to 1984 | Employer: Wabash College | Title: Assistant Professor of Chemistry | Department: Chemistry |
Responsibilities:He taught courses in undergraduate chemistry. |
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Government Experience
| Years | Agency | Role | Description |
|---|---|---|---|
| Years: 1984 to 1988 | Agency: NIH/NIEHS | Role: Senior Visiting Scientist | Description: Expert conducted research on the role of free radicals and antioxidants in health. |
International Experience
| Years | Country / Region | Summary |
|---|---|---|
| Years: 1985 to 1987 | Country / Region: Germany | Summary: Expert conducted research as a Fulbright Scholar at the GSF, a German Federal Research Institute. |
Career Accomplishments
| Associations / Societies |
|---|
| Expert is a member of the Society for Free Radical Biology and Medicine. He is immediate Past President of that organization. He is also a member of the International Society for Free Radical Research, the American Society for Photobiology, the Radiation Research Society, and the American Chemical Society. |
| Professional Appointments |
|---|
| Expert serves on the editorial board of Free Radical in Biology Medicine as well as Archives Biochemistry and Biophysics. |
| Awards / Recognition |
|---|
| Expert was a Fulbright Scholar in Germany at the GSF Research Institute from 1985-1987. He received the Master Teacher Award from the Oxygen Society, 1999-present. Three of his research papers were honored as "Citation Classics" by the Institute for Scientific Information. He is Immediate Past President of the Society for Free Radical Biology and Medicine. He also was honored as a large volume blood donor. |
| Publications and Patents Summary |
|---|
| Expert has published over 100 technical papers in his field. |
Fields of Expertise
electron paramagnetic resonance spectroscopy, electron paramagnetic resonance, biological antioxidant, ascorbic acid, tocopherol, superoxide dismutase, oxygen radical biochemistry, free radical chemistry, free radical biochemistry, free radical, chelating agent, photosensitization, lipid oxidation, nitric oxide, nitroxide, nitrone, adduct, iron chelating agent, oxidizing agent chemistry, biological oxidation, flash photolysis, oxidative tissue injury, peroxide oxidation, peroxidase, magnetic resonance, antioxidant, thiol compound, oxygen, photochemical reaction, chemical kinetics, vitamin, photochemistry, paramagnetism, oxygen chemistry, kinetics, iron environmental effect, iron, glutathione, food antioxidant, cancer treatment