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Expert designed and synthesized multifunctional surface chemistries for modification of glass, porous silica gels, carbon and various polymeric substrates in form of the membranes, micro particles, porous monolithic blocks, and capillaries. The following methods have been used for surface functionalzation: grafting, coating, living polymerization, treatment with specially designed silane and organometallic reagents. Expert also designed and produced multifunctional surface architectures in sequential routs, which are similar to the synthesis of dendrimers.
Many of the developed products were patented, and are used in various fields of analytical chemistry and separation science such as IC, HPLC, HIC and affinity chromatography; water treatment, isoelectric focusing of proteins, immobilization of peptides, proteins and antibodies. Multiple prototypes of these novel materials were commercialized by Dionex Co. and Cell Biosciences Co.
Expert’s recent work is associated with the development of novel biocompatible surfaces and the surfaces that are capable of capturing biomolecules.

Expert has been designing and synthesizing various multi functional monomers containing vinyl, allylic, styrenic, acrylic, 1,4-diene, maleic anhydride and other polymerizable groups. He is an expert in transferring the developed synthetic processes to manufacturing, and designing new surfaces using radical, cationic, anionic and metal ion induced polymerization processes. Expert also designed the monomers containing acryl amide, silane, metal ion chelating, ion-exchange and chiral groups; and also epoxide, carbohydrate, benzophenone and other reactive moieties for their further incorporation into brush and bulk co-polymers using various polymerization techniques. Some of these novel monomers have been patented and used in commercial products introduced by Dionex Co. and Cell Biosciences Co.

Expert has been developing various multi functional copolymers that were grafted onto or from the surfaces of different substrates such as glass, carbon, silica gel, polyurethane and styrenic foams, styrenic and acrylic polymers, capillaries and microparticles of various pore sizes and pore volumes. Graft copolymers comprised the ion-exchange sites, various reactive functionalities, perfluorinated blocks, carbohydrate and polyethoxyethylene fragments; and also functional groups for further cross-linking and protein immobilization. Expert has an unique expertise in custom design of grafted surfaces with precise balance of hydrophobic and hydrophilic functionalities that are compatible with blood samples, and conditions for various bio applications. The developed products were produced using radical thermal, UV and metal ion initiation in solution, and also surface attached initiators. Expert applied techniques such as living polymerization, molecular imprinting, and reversed emulsion polymerization, and also multi layer coating for covalent and adsorptive surface modification.




Expert has developed various biocompatible polymers for the purpose of protein separation, capture and analysis. Expert’s recent work involves designing the glass surfaces modified with biocompatible polymers for the analysis of proteins by combination of isoelectric focusing, photo capture of proteins, and their identification/quantification by antibodies. He designed and produced several polymer formulations comprising hydrophilic polymers grafted with photo reactive moieties and functional groups for either covalent or adsorptive surface modification. The designed products have been patented, and are at the initial stage of commercialization. The end user is expected to study blood samples or any other biological fluids for the presence of biomolecules of interest. The developed functional polymers are used in the automatic system that revolutionizes the analysis of proteins and their phosphorylated forms, and adds new value to the Western blot method.

Expert is an expert in technology transfer and in all stages of product design, feasibility, development, patenting, manufacturing and outsourcing. The commercial products that Expert developed, were carried through the entire introduction cycle including a pilot scale production, QC and market positioning against the competitors products. The commercialized products include several families of polymeric and silica gel stationary phases for various types of chromatographic separation and solid phase extraction, various types of functional polymers and gels for coatings and surface modification, several families of novel silane reagents bearing additional reactive moieties, functionalized capillaries for analytical applications, biocompatible surfaces, functionalized polymeric membranes and particles for water treatment, multi functional monomers, polymerizable metal ion complexing agents, and also various peptide molecules used as standards for isoelectric focusing of proteins.

Expert has designed various peptide molecules and managed a group of synthetic organic chemists to produce those molecules using ABI peptide synthesizer. All peptides were designed for the purpose of their using as standards in isoelectric focusing of proteins and antibodies. In addition to specific sequences of aminoacids providing a peptide molecule with a particular pI value, other functionalities were introduced via multi step processes. These functionalities carry fluorescent labels and photoactive moieties for peptide immobilization.

Expert has been involved in designing various separation media, biocompatible materials, and surfaces for selective binding/extraction of bio molecules, small molecules of pharmaceuticals, ions and chiral substrates. Many of these developed products were patented and commercialized for their use in HPLC, IC, HIC, affinity, chiral chromatography, membrane separation, water treatment, and also in isoelectric focusing of proteins and antibodies. Expert has deep knowledge of separation science and surface interactions with analytes during their separation, selective extraction, detection or sensing. He has developed a unique expertise in precise balancing the ratio of hydrophobic, hydrophilic and ion-exchange characteristics of functionalized surfaces, and tailoring the surface properties to a particular application. In his designs, Expert combines a sophistication of latest scientific research with low cost and manufacturability of the potential commercial products.